| Project/Area Number |
15K09889
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
藤中 俊之 独立行政法人国立病院機構大阪医療センター(臨床研究センター), その他部局等, 研究員 (00359845)
伊井 仁志 大阪大学, 基礎工学研究科, 特任准教授(常勤) (50513016)
和田 成生 大阪大学, 基礎工学研究科, 教授 (70240546)
中村 元 大阪大学, 医学系研究科, 助教 (80533794)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脳動脈瘤 / 壁運動 / MRI / 血流シュミレーション / CFD / phase contrast / vessel wall imaging / 血管壁イメージング / 拍動 / 頚動脈 / black blood image |
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| Outline of Final Research Achievements |
The aim of this research was to develop an MRI imaging method that can measure vessel wall motion accompanying the cardiac cycle, and to establish the new parameters of the cerebral aneurysm wall and blood flow. We attempted intracranial MR imaging to visualize the movement of the arterial wall, but it is difficult to express motion of the blood vessel wall with high accuracy with heartbeat. In cervical blood vessels, surface coils can be used, and it has become possible to use vessel wall imaging that suppresses intravascular signals with special pulses. Currently the T1-TSE method using MSDE is developed to image the vessel wall after different TI time. I got an image of 10 phases of 1 heart beat in 5 minutes. Recent updates of MR units, we are try to visualize the blood vessel wall in the brain.
Apart from this study, we investigated improvement of CFD accuracy from all blood flow information using 4D-Flow MRI and developed a new feedback control method.
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