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Computer-aided quantification of interstitial lung abnormalities on computed tomography

Research Project

Project/Area Number 15K09901
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionYokohama City University

Principal Investigator

Iwasawa Tae  横浜市立大学, 医学研究科, 客員教授 (40625175)

Co-Investigator(Renkei-kenkyūsha) GOTOH Toshiyuki  横浜国立大学, 環境情報学府, 教授 (30234991)
MURAYAMA Sadayuki  琉球大学, 医学系研究科, 教授 (60239548)
SAKAI Fumikazu  埼玉医科大学, 医学部国際医療センター放射線科, 教授 (30153852)
INOUE Tomio  横浜市立大学, 医学研究科, 教授 (80134295)
Research Collaborator OGURA Takashi  
KITAMURA Hideya  
BABA Tomohisa  
TAKEMURA Tamiko  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2016: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
KeywordsCT / computer-aided diagnosis / lung / pulmonary fibrosis / Computed tomography / Compter diagnosis / Interstitial penimonia / MDCT / CAD / interstitial pneumonia
Outline of Final Research Achievements

The subject of this study was to recognize feasibility of Gaussian Histogram Normalized Correlation (GHNC) system, which is a quantifying system for CT images of interstitial pneumonias. Iwasawa, Gotoh, and Iwao have improved GHNC and developed the method for extracting subpleural region and quantifying the subpleural fibrosis. We found the subpleural fibrosis can differentiate idiopathic pulmonary fibrosis and non-specific interstitial pneumonia (Iwasawa T, et al, Eur J Radiol 2017, 90(17),106-113, Iwasawa T, et al. Jpn J Radiol. 2018 36(3):165-180). Iwasawa, Gotoh, and Iwao filed a patent for this method (PCT/JP2017/007668). We also evaluated low-dose CTs and CTs obtained different CT scanners using GHNC(Takehara S, et al, ECR2018), and we recognized feasibility of GHNC. We are investigating the cases of Japan Idiopathic Interstitial Pneumonia Registry (NEJ-030) using GHNC.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (15 results)

All 2018 2017 2016 2015

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 2 results) Presentation (8 results) (of which Int'l Joint Research: 4 results,  Invited: 3 results) Book (1 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Smoking-related lung abnormalities on computed tomography images: comparison with pathological findings.2018

    • Author(s)
      Iwasawa, T. Takemura, T. Ogura, T.
    • Journal Title

      Jpn J Radiol.

      Volume: 36 Issue: 3 Pages: 165-180

    • DOI

      10.1007/s11604-017-0713-0

    • NAID

      210000170250

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extraction of the subpleural lung region from computed tomography images to detect interstitial lung disease.2017

    • Author(s)
      Iwasawa T, Iwao Y, Takemura T, Okudela K, Gotoh T, Baba T, Ogura T, Oba MS.
    • Journal Title

      Jpn J Radiol.

      Volume: 35 Issue: 11 Pages: 681-688

    • DOI

      10.1007/s11604-017-0683-2

    • NAID

      50012797181

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The importance of subpleural fibrosis in the prognosis of patients2017

    • Author(s)
      Tae Iwasawa, Tamiko Takemura, Koji Okudera, Toshiyuki Gotoh, Yuma Iwao,
    • Journal Title

      European Journal of Radiology

      Volume: 印刷中

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 大動脈経由の再灌流を考慮した造影MR血流解析報2016

    • Author(s)
      坂知樹 後藤敏行 影井清一郎 岩澤多恵
    • Journal Title

      Medical Imaging Technology

      Volume: 34 Pages: 245-258

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multicenter study of quantitative computed tomography analysis using a computer-aided three-dimensional system in patients with idiopathic pulmonary fibrosis2016

    • Author(s)
      Tae Iwasawa , Tetsu Kanauchi, Toshiko Hoshi, Takashi Ogura, Tomohisa Baba, Toshiyuki Gotoh, Mari S. Oba
    • Journal Title

      Japanese Journal of Radiology

      Volume: 34 Issue: 1 Pages: 16-27

    • DOI

      10.1007/s11604-015-0496-0

    • NAID

      210000180534

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Comparison of ultra-low-dose computed tomography (ULDCT) and standard-dose computed tomography (SDCT) for the detection of interstitial lung disease2018

    • Author(s)
      Takehara S, Iwasawa T, Baba T, Ogura T, Mari S. Oba
    • Organizer
      European Congress of Radiology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Computer-based Computed Tomography Analysis for Detecting Interstitial Lung Disease; A prospective study.2018

    • Author(s)
      Takehara S, Iwasawa T, matsui K, Tsuchiya N, Murayama S, Ogura T,
    • Organizer
      第77回日本医学放射線学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Improvement in the diagnosis of interstitial pulmonary fibrosis (IPF) with computer-aided diagnosis system of Computed Tomography images.2017

    • Author(s)
      Ryo Fujita, Tae Iwasawa, Takatoshi Aoki, Kentaro Matsui, Takashi Ogura, Tomio Inoue
    • Organizer
      8th International Workshop on Pulmonary Functional Imaging
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2017-03-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 喫煙関連間質性肺疾患の画像診断2017

    • Author(s)
      岩澤多恵
    • Organizer
      第53回日本医学放射線学会秋季臨床大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Smoking related interstitial lung disease; A puzzling problem in interstitial pneumonias2016

    • Author(s)
      Iwasawa T, Takemura T, Baba T, Ogura T, and Gotoh T.
    • Organizer
      Radiological Society of North America   Chicago 2016
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2016-11-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] コンピュータによる間質性肺炎のCT画像の定量評価2016

    • Author(s)
      岩澤多恵
    • Organizer
      呼吸機能イメージング研究会 第2回サマーセミナー
    • Place of Presentation
      福岡国際会議場(福岡市博多区)
    • Year and Date
      2016-09-23
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 間質性肺炎の呼吸機能イメージングと臨床応用2016

    • Author(s)
      岩澤多恵
    • Organizer
      第52回日本医学放射線学会秋季臨床大会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2016-09-16
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Volume of normal lung on CT correlates with right ventricular function and prognosis of patients with chronic fibrosing interstitial pneumonitis2015

    • Author(s)
      T. Iwasawa, S. Kato, A. Sekine,T. BaBa, and T. Ogura,
    • Organizer
      Scientific Assembly and Annual Meetings of Radiological Society of North America
    • Place of Presentation
      マコーミックプレイス・シカゴ(アメリカ合衆国)
    • Year and Date
      2015-11-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Book] 日本胸部臨床 びまん性肺疾患のCAD2016

    • Author(s)
      岩澤多恵
    • Total Pages
      17
    • Publisher
      克誠堂出版
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 肺野病変の診断支援装置、該装置の制御方法およびプログラム2017

    • Inventor(s)
      岩澤多恵、後藤敏行、岩男悠馬
    • Industrial Property Rights Holder
      神奈川県立循環器呼吸器病センター、横浜国立大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017-02-28
    • Related Report
      2016 Research-status Report
    • Overseas

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Published: 2015-04-16   Modified: 2019-03-29  

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