Development of radioiodine-labeled nanoparticle carrier with in vivo stability and tumor recognition ability for nuclear medicine
| Project/Area Number |
15K09903
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Tohoku Medical and Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KIMURA Shunsaku 京都大学, 工学研究科, 教授 (80150324)
MAKINO Akira 福井大学, 高エネルギー医学研究センター, 准教授 (00566226)
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| Research Collaborator |
OZEKI Ei-ichi 株式会社島津製作所, 基盤技術研究所
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 分子イメージング / 腫瘍 / 放射性標識 / SPECT / 創薬 / 放射性標識合成 / セラノスティクス / 体内動態 / マウス / インビボ / ナノ粒子 / PET |
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| Outline of Final Research Achievements |
Lactosome is nanocarrier with stealth and tumor recognition ability. We reported previously a successful in vivo imaging of mouse tumor of radio-labeled Lactosome as the preliminary study with using small animal PET or SPECT. However, its tumor uptake rate was slow and there was a suspicion that the biodistribution of radioactivity did not reflect that of Lactosomes.
As well as finding more stable radiolabeled lactosomes in vivo, improvement of drug design, such as high tumor recognition ability, is necessary in order to shorten the imaging time. In this study, we tried to find stable iodine-labeled lactosomes in vivo and synthesized radioactive lactosomes incorporating folate receptor ligand on its surface.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Isomeric iodinated analogs of nimesulide: synthesis, physicochemical characterization, cyclooxygenase-2 inhibitory activity, and transport across Caco-2 cells2016
Author(s)
Yamamoto Y., Arai J., Hisa T., Saito Y., Mukai T., Ohshima T., Maeda M., and Yamamoto F
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Journal Title
Bioorg. Med. Chem
Volume: 24
Pages: 3727-3733
Related Report
Peer Reviewed
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[Journal Article] Inflammation-Induced Synergetic Enhancement of Nanoparticle Treatments with DOXI and 90Y-Lactosome for Orthotopic Mammary Tumor2016
Author(s)
Kensuke Kurihara, Motoki Ueda, Isao Hara, Eri Hara, Kohei Sano, Akira Makino, Eiichi Ozeki, Fumihiko Yamamoto, Hideo Saji, Kaori Togashi, Shunsaku Kimura
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Journal Title
J.Nanopart.Res.
Volume: 18
Pages: 137-137
Related Report
Peer Reviewed
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[Journal Article] Inflammation-Induced Synergetic Enhancement of Nanoparticle Treatments with DOXIL® and ⁹⁰Y-Lactosome for Orthotopic Mammary Tumor2016
Author(s)
Shunsaku Kimura, Kensuke Kurihara, Motoki Ueda, Isao Hara, Eri Hara, Kohei Sano, Akira Makino, Eiichi Ozeki, Fumihiko Yamamoto, Hideo Saji, Kaori Togashi
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Journal Title
J.Nanopart.Res.
Volume: in press
Related Report
Peer Reviewed
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