| Project/Area Number |
15K09907
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
辻 裕之 金沢医科大学, 医学部, 教授 (00155368)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 頭頸部癌 / 化学放射線療法 / perfusion CT / 定量化 / 放射線治療 / 機能画像 / biomarker / perfuison CT / volume perfuiosn |
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| Outline of Final Research Achievements |
Perfusion CT imaging(PCT) provides usful information regarding a tumor's vascular physiology and hemodynamics. We investigated the feasibility of PCT for the diagnostic performance of head and neck cancer(HNC), and the prediction of treatment outcome to chemoradiotherapy for HNC patients. As a result, PCT provided the usiful informations for the evaluation of tumor spread aera and the detection of metastatic cervical lymph node using quantification. In addition, pre-treatment BF and BV values of primary tumor, and the fractional change in BF and BV value during treatmnet correlated with the RECIST classification and tumor regresion ratio.
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