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Proposal and evaluation of mediastinal compartment classification and staging using image diagnosis of mediastinal tumors

Research Project

Project/Area Number 15K09909
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionKurume University

Principal Investigator

FUJIMOTO KIMINORI  久留米大学, 医学部, 教授 (00199366)

Co-Investigator(Kenkyū-buntansha) 酒井 文和  埼玉医科大学, 医学部, 教授 (30153852)
原 眞咲  名古屋市立大学, 大学院医学研究科, 高度医療教育研究センター教授 (50244562)
富山 憲幸  大阪大学, 医学系研究科, 教授 (50294070)
楠本 昌彦  国立研究開発法人国立がん研究センター, 中央病院, 科長 (90252767)
Research Collaborator SUMI akiko  
KUHARA asako  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords縦隔腫瘍 / 胸腺上皮性腫瘍 / 縦隔区画 / 画像診断 / CT / MRI / 病期分類 / 予後因子 / 縦隔区分 / TNM国際病期分類
Outline of Final Research Achievements

1) Using digital images of 500 cases of mediastinal mass lesions, the Japan Association for Research on the Thymus (JART) mediastinal compartment classification method (four-compartments method) proposed by this research group and the methodology of the International Thymic Malignancy Interest Group (ITMIG) (three-compartments method) which was defined with reference to our JART method were compared. There was no difference between them, and it was concluded that it would be convenient to use the latter as an international standard.
2) With regard to the new international TNM classification and tissue classification, various imaging findings obtained by CT and MRI of our 100 and more cases were assessed. Important results were obtained such as correlation with tissue classification, definition of important imaging findings to support TNM classification, and imaging findings as prognostic factors.

Academic Significance and Societal Importance of the Research Achievements

これまで縦隔の区画法に関して国際基準となる方法論はなかったが、本研究グループが世界で初めてCT横断画像を用いた区画法を提案した。これを参考として胸腺悪性腫瘍研究グループ(ITMIG)が新提案を行ったが、実際には症例の検討は行われていなかった。本研究では、これを検証することで国際基準足ることを示すことができたと考える。
胸腺上皮性腫瘍は希少疾患であり、多数例のCT、MRIの多角的な検討は難しいが、本研究では、組織分類との相関、TNM分類の一助として、また予後因子となる画像所見を示すことができ、胸腺腫瘍の診療において役立つ情報を与えることができたと考える。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (52 results)

All 2018 2017 2016 2015

All Journal Article (17 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 9 results,  Open Access: 3 results) Presentation (25 results) (of which Int'l Joint Research: 9 results,  Invited: 7 results) Book (10 results)

  • [Journal Article] Is there any consensus of long-term follow-up for incidental anterior mediastinal nodular lesions?2018

    • Author(s)
      Sumi A, Fujimoto K.
    • Journal Title

      Shanghai Chest

      Volume: 2 Pages: 97-97

    • DOI

      10.21037/shc.2018.12.01

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of the pericardiacophrenic vein on CT2018

    • Author(s)
      Ozawa Yoshiyuki、Suzuki Ritsuko、Hara Masaki、Shibamoto Yuta
    • Journal Title

      Cancer Imaging

      Volume: 18 Issue: 1 Pages: 1-1

    • DOI

      10.1186/s40644-017-0134-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Volumetric analysis of the thymic epithelial tumors: correlation of tumor volume with the WHO classification and Masaoka staging2018

    • Author(s)
      Sato Yukihisa、Yanagawa Masahiro、Hata Akinori、Enchi Yukihiro、Kikuchi Noriko、Honda Osamu、Nakanishi Katsuyuki、Tomiyama Noriyuki
    • Journal Title

      Journal of Thoracic Disease

      Volume: 10 Issue: 10 Pages: 5822-5832

    • DOI

      10.21037/jtd.2018.09.133

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 画像診断道場 実はこうだった 胸部異常影を指摘できますか?(胸腺癌)2018

    • Author(s)
      久原麻子,角 明子,藤本公則
    • Journal Title

      週刊 日本医事新報

      Volume: 4903 Pages: 1-2

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 画像診断道場 実はこうだった 続・胸部異常影を指摘できますか?(肺血管影に注意!)(肺底動脈体動脈起始症)2018

    • Author(s)
      久木山智子,小金丸雅道,藤本公則
    • Journal Title

      週刊 日本医事新報

      Volume: 4918 Pages: 1-2

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 縦隔の解剖学的区分と正常像2018

    • Author(s)
      原 眞咲
    • Journal Title

      週間日本医事新報

      Volume: 4899 Pages: 22-29

    • Related Report
      2017 Research-status Report
  • [Journal Article] Editorial on “Distribution of malignant lymphomas in the anterior mediastinum: a singleinstitution study of 76 cases in Japan, 1997-2016”2018

    • Author(s)
      Sumi Akiko、Fujimoto Kiminori
    • Journal Title

      Mediastinum

      Volume: 2 Pages: 13-13

    • DOI

      10.21037/med.2018.03.02

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] JLCS medical practice guideline for thymic epithelial tumors: summary of recommendations2017

    • Author(s)
      Yokoi K, Kondo K, Fujimoto K, Hara M, Kadota Y, Kawaguchi K, Kunitoh H, Matsuno Y, Nakajima J, Nishio M, Ogawa K, Omasa M
    • Journal Title

      Jpn J Clin Oncol

      Volume: 47 Issue: 12 Pages: 1119-1122

    • DOI

      10.1093/jjco/hyx138

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 縦隔の区分 mediastinal compartments 特集「基本から身につく縦隔・胸膜の画像診断」2017

    • Author(s)
      原 眞咲
    • Journal Title

      画像診断

      Volume: 37 Pages: 1151-1162

    • Related Report
      2017 Research-status Report
  • [Journal Article] Mature Cystic Teratoma With an Element of Hepatocellular Carcinoma in Anterior Mediastinum Magnetic Resonance-Pathologic Correlation.2017

    • Author(s)
      Sumi A, Nagata S, Zaizen M, Murakami D, Takamori S, Abe H, Tanikawa K, Fujimoto K.
    • Journal Title

      J Thorac Imaging

      Volume: 32 Issue: 6 Pages: 84-86

    • DOI

      10.1097/rti.0000000000000301

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Value of MRI and Clinical Features in Differentiating Between Cellular and Fibrous Solitary Fibrous Tumors.2016

    • Author(s)
      Nagata S, Nishimura H, Amrami KK, Akiba J, Tonan T, Fujimoto K, Abe T.
    • Journal Title

      AJR Am J Roentgenol

      Volume: 208 Issue: 1 Pages: 10-17

    • DOI

      10.2214/ajr.16.16423

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 所見から迫る胸部CT-前縦隔病変2016

    • Author(s)
      原 眞咲
    • Journal Title

      日本胸部臨床

      Volume: 75 Pages: 76-89

    • Related Report
      2015 Research-status Report
  • [Journal Article] 所見から迫る胸部CT-後縦隔(脊椎傍区画)腫瘤性病変2016

    • Author(s)
      本廣賢子,長田周冶,藤本公則
    • Journal Title

      日本胸部臨床

      Volume: 75 Pages: 300-311

    • Related Report
      2015 Research-status Report
  • [Journal Article] Asymptomatic Saccular Aneurysm of the Superior Vena Cava2015

    • Author(s)
      Kuhara A, Fujimoto K, Koganemaru M, Abe T
    • Journal Title

      Internal Medicine

      Volume: 54 Issue: 18 Pages: 2419-2420

    • DOI

      10.2169/internalmedicine.54.4815

    • NAID

      130005099667

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Associations between computed tomography features of thymomas and their pathological classification2015

    • Author(s)
      Ozawa Y, Hara M, Shimohira M, Sakurai K, Nakagawa M, Shibamoto Y
    • Journal Title

      Acta Radiol

      Volume: Epub

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 胸腺病理の基礎と臨床-胸腺腫瘍の画像診断2015

    • Author(s)
      原 眞咲
    • Journal Title

      病理と臨床

      Volume: 33 Pages: 708-713

    • Related Report
      2015 Research-status Report
  • [Journal Article] 胸腺上皮性腫瘍の術前評価における画像上のピットフォール2015

    • Author(s)
      2)小澤良之,原 眞咲,鈴木梨津子,平生和夫,関口知也,島村泰輝,坂東勇弥,芝本雄太
    • Journal Title

      臨床放射線

      Volume: 60 Pages: 61-69

    • Related Report
      2015 Research-status Report
  • [Presentation] 縦隔疾患の画像診断② 中・後縦隔腫瘤性病変の画像診断2018

    • Author(s)
      藤本公則
    • Organizer
      第77回日本医学放射線学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 胸腺上皮性腫瘍のMRI診断2018

    • Author(s)
      久原麻子、藤本公則
    • Organizer
      第21回分子標的部門研究会BMWS~Bio Molecular Working Section~
    • Related Report
      2018 Annual Research Report
  • [Presentation] Imaging of paraganglioma in various organs:a comprehensive review2018

    • Author(s)
      Nagata S, Nishimura H, Kimberly K.A, Tonan T, Sumi A, Uchiyama Y, Kurata S, Tanaka N, Fujimoto K, Abe T
    • Organizer
      Annual Meeting of Radiological Society of North America 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 胸腺悪性腫瘍診療における画像診断の役割2018

    • Author(s)
      藤本公則
    • Organizer
      第38回日本胸腺研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 縦隔疾患の画像診断① 縦隔の区分2018

    • Author(s)
      原 眞咲
    • Organizer
      第77回日本医学放射線学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 肝転移を伴うatypical type A thymoma variant との鑑別を要した胸腺腫の1手術例2018

    • Author(s)
      堀田直秀,上嶋佑樹,原 眞咲,ほか
    • Organizer
      第32回胸部放射線研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 胸腺上皮性腫瘍の画像所見と、2015年改訂WHO分類および新しく提唱されているTNM分類との検討2017

    • Author(s)
      角 明子,藤本公則
    • Organizer
      第9回分子標的部門研究会BMWS~Bio Molecular Working Section~
    • Place of Presentation
      久留米市
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] CT Features of Thymic Epithelial Tumors:Correlation with New WHO Histologic Classification and TNM Staging Systems2017

    • Author(s)
      角 明子,藤本公則,久原麻子,池原奈央子,岩本良二,佐土原順子,長田周治, 安陪等思
    • Organizer
      第76回日本医学放射線学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] CT features of focal atelectasis that can mimic pleural dissemination in preoperative evaluation of thymic epithelial tumors2017

    • Author(s)
      Omata S, Ozawa Y, Nakagawa M, Hara M, Shibamoto Y.
    • Organizer
      4th World Congress of Thoracic Imaging
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Volumetric Analysis of the Thymic Epithelial Tumors: Correlation with WHO classification and Masaoka Staging2017

    • Author(s)
      Tomiyama N, Sato Y, Yanagawa M, Honda O.
    • Organizer
      Fleischner Society Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 画像からみる新WHO分類:放射線科医として知っておきたいこと ―肺・縦隔腫瘍―2017

    • Author(s)
      楠本昌彦
    • Organizer
      第46回 Radiology Update Fukuoka学術講演会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] マルチモダリティ時代の胸部単純写真の役割2017

    • Author(s)
      藤本公則
    • Organizer
      第53回日本医学放射線学会秋季臨床大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Differential diagnosis of mediastinal tumors based on a new mediastinal compartment classification on CT2017

    • Author(s)
      Tomiyama N
    • Organizer
      State of the Art in Chest Imaging International Symposium
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] CT Features of Thymic Epithelial Tumors : Correlation with the Clinical stage classification using the recently proposed TNM staging system.2017

    • Author(s)
      Sumi A, Fujimoto K, Kuhara A, Kawaguchi A, Ikehara N, Nagata S, Abe T.
    • Organizer
      Radiological Society of North America 2017 Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] MR Imaging Characteristics of Thymic Epithelial Tumors : Correlation with WHO histological classification and new TNM.2017

    • Author(s)
      Kuhara A, Fujimoto K, Sumi A, Kawaguchi A, Ebata T, Nagata S, Ikehara N, Abe T
    • Organizer
      Radiological Society of North America 2017 Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] CT Diagnosis for Thymic Epithelial Tumors:Correlation with the World Health Organization Histologic Classification system Updated in 2015 and New TNM Staging System.2016

    • Author(s)
      Sumi A, Fujimoto K, Kuhara A, Ikehara N, Iwamoto R, Nagata S, Abe T.
    • Organizer
      Radiological Society of North America (RSNA2016)
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2016-11-26
    • Related Report
      2016 Research-status Report
  • [Presentation] Evaluation of Tumor Invasiveness of Thymic Epithelial Tumors using Magnetic Resonance Imaging:Correlation with the World Health Organization Histologic Classification System Updated in 2015 and Masaoka-Koga Staging System.2016

    • Author(s)
      Kuhara A, Fujimoto K, Sumi A, Ebata T, Nagata S, Abe T.
    • Organizer
      Radiological Society of North America (RSNA2016)
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2016-11-26
    • Related Report
      2016 Research-status Report
  • [Presentation] Do you Know the Formation Process of Cysts and Cavities? : Radiologic-pathologic Correlation and Spectrum of Diseases?2016

    • Author(s)
      Johkoh T, Fukuoka J, Ichikado K, Fujimoto K, Tomiyama N.
    • Organizer
      Radiological Society of North America (RSNA2016)
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2016-11-26
    • Related Report
      2016 Research-status Report
  • [Presentation] Eosinophil-associated Diseases:A Review.2016

    • Author(s)
      Nagata S, Nishimura H, K K Amrami, Sumi A, Kuhara A, Ebata T, Hirose Y, Himuro H, Tonan T, Uchiyama Y, Fujimoto K, Abe T.
    • Organizer
      Radiological Society of North America (RSNA2016)
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2016-11-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 前縦隔腫瘍(mucinouscyst adenoma of th ethymus)の1例2016

    • Author(s)
      近末智雅,角 明子,江畑智広,久原麻子,岩本良二,佐土原順子,秋葉 純,藤本公則
    • Organizer
      第48回福岡胸部放射線研究会
    • Place of Presentation
      福岡市
    • Year and Date
      2016-10-29
    • Related Report
      2016 Research-status Report
  • [Presentation] 肝細胞癌成分を伴う縦隔成熟嚢胞性奇形腫の1例2016

    • Author(s)
      財前 翠,藤本公則,江畑智広,村上大悟,角 明子,大島孝一,内田政史,安陪等思
    • Organizer
      第30回胸部放射線研究会
    • Place of Presentation
      福岡市
    • Year and Date
      2016-09-16
    • Related Report
      2016 Research-status Report
  • [Presentation] 胸部画像診断の進歩と展望2016

    • Author(s)
      藤本公則
    • Organizer
      第70回久留米医学会総会
    • Place of Presentation
      久留米市
    • Year and Date
      2016-04-22
    • Related Report
      2016 Research-status Report
  • [Presentation] Image findings of fat containing mediastinal lesions2016

    • Author(s)
      Maki H, Ozawa Y, Ishihara Y, Nakagawa M, Shibamoto Y, Hara M
    • Organizer
      European Congress of Radiology 2016
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2016-03-02
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Image findings of diseases of the middle mediastinum2016

    • Author(s)
      Ozawa Y, Hara M, Ishihara Y, Shibamoto Y
    • Organizer
      European Congress of Radiology 2016
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2016-03-02
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Tumor invasiveness of thymic epithelial tumors evaluated with  magnetic resonance imaging: Correlation with the World Health  Organization histologic classification and Masaoka-Koga staging system2016

    • Author(s)
      Kuhara A, Fujimoto K, Sumi A, Ebata T, Ikehara N, Iwamoto R, Sadohara J,  Nagata S, Abe T
    • Organizer
      10th American Association for Cancer Research(AACR)-Japanese Cancer Association(JCA) Joint Conference
    • Place of Presentation
      Maui, Hawaii, USA
    • Year and Date
      2016-02-16
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Book] 胸部のCT第4版(Ⅴ縦隔腫瘍 3胸腺腫以外の前縦隔腫瘍)2018

    • Author(s)
      藤本公則,佐土原順子,角 明子
    • Total Pages
      887
    • Publisher
      メディカル・サイエンス・インターナショナル
    • Related Report
      2018 Annual Research Report
  • [Book] 肺癌診療ガイドライン 2018年版2018

    • Author(s)
      特定非営利活動法人日本肺癌学会(藤本公則、原眞咲、楠本昌彦)
    • Total Pages
      420
    • Publisher
      金原出版
    • ISBN
      9784307203913
    • Related Report
      2018 Annual Research Report
  • [Book] Lung Disease Associated with Rheumatoid Arthritis (Chapter 8: Radiological characteristics of CTD-ILD)2018

    • Author(s)
      Fujimoto K
    • Total Pages
      199
    • Publisher
      Springer
    • ISBN
      9789811067495
    • Related Report
      2018 Annual Research Report
  • [Book] 胸部のCT第4版(1.縦隔の解剖 III.肺縦隔の正常解剖とCT像)(1.縦隔腫瘍の診断へのアプローチ IV.縦隔腫瘍)(4.中・後縦隔腫瘍 IV.縦隔腫瘍)2018

    • Author(s)
      原 眞咲
    • Total Pages
      887
    • Publisher
      メディカル・サイエンス・インターナショナル
    • Related Report
      2018 Annual Research Report
  • [Book] エキスパートから学ぶ 読影の手立てとなる局所解剖と画像診断2018

    • Author(s)
      久原麻子,藤本公則
    • Total Pages
      307
    • Publisher
      メジカルビュー社
    • Related Report
      2017 Research-status Report
  • [Book] 画像診断ガイドライン2016年版2016

    • Author(s)
      芦澤和人,岩澤多恵,負門克典,岡田文人,加藤勝也,上甲剛,神谷武志,草野涼,坂井秀二,澄川裕允,田中伸幸,中園貴彦,林秀行,藤本公則,松岡伸,村山貞之,藪内英剛
    • Total Pages
      580
    • Publisher
      金原出版
    • Related Report
      2016 Research-status Report
  • [Book] EBMの手法による肺癌診療ガイドライン,悪性胸膜中皮腫・胸腺腫瘍含む2016

    • Author(s)
      横井香平,近藤和也,藤本公則,ほか
    • Total Pages
      333
    • Publisher
      金原出版
    • Related Report
      2016 Research-status Report
  • [Book] 腫瘤性病変-縦隔腫瘤 Q8,9,10 (ビギナーのための胸部画像診断 Q&A アプローチ)2016

    • Author(s)
      原 眞咲
    • Total Pages
      219
    • Publisher
      学研メディカル秀潤社
    • Related Report
      2015 Research-status Report
  • [Book] リンパ腫とその他の縦隔腫瘍の鑑別,リンパ腫の亜分類の鑑別 (見る診る語る 呼吸器画像診断のコツ)2015

    • Author(s)
      佐土原順子,藤本公則
    • Total Pages
      135
    • Publisher
      克誠堂出版株式会社
    • Related Report
      2015 Research-status Report
  • [Book] 前縦隔腫瘍の鑑別診断はどこまで可能か? (見る診る語る 呼吸器画像診断のコツ)2015

    • Author(s)
      原 眞咲,小澤良之
    • Total Pages
      135
    • Publisher
      克誠堂出版株式会社
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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