| Project/Area Number |
15K09916
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | University of Fukui |
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Principal Investigator |
Kimura Hirohiko 福井大学, 学術研究院医学系部門, 教授 (10242596)
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| Co-Investigator(Kenkyū-buntansha) |
藤原 康博 熊本大学, 大学院生命科学研究部(保), 講師 (90422675)
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| Co-Investigator(Renkei-kenkyūsha) |
TSUJI KAZUNOBU 福井大学, 学術研究院医学系部門, 助教 (00645773)
HIGASHINO YOSHIFUMI 福井大学, 学術研究院医学系部門, 助教 (80554542)
OKAZAWA HIDEHIKO 福井大学, 高エネルギー医学研究センター, 教授 (50360813)
TSUJIKAWA TETSUYA 福井大学, 高エネルギー医学研究センター, 准教授 (30380033)
ISHIDA SHOTA 福井大学, 学術研究院医学系部門(附属病院部), 診療放射線技師 (50817559)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | Arterial Spin Labeling / MR perfusion / ｐCASL / 脳循環代謝 / 閉塞性脳血管障害 / MRI / Arterial spin labeling / ASL / perfusion / brain / CBF / CBV / Arterial spin labeling / 脳血流 / MR perfusion |
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| Outline of Final Research Achievements |
Arterial spin labeling (ASL) is a means of non-invasive MR perfusion assessment, which can provide a quantitative value of cerebral blood flow (CBF). However, quantitative measurement of CBF with this method depends on a number of parameters including T1 of brain and arterial transit time (DELTA). Arterial transit time has most significant effect for the accuracy of CBF calculation due to the errors of fixed parameters. In the current study, we have demonstrated the feasibility of ATT calculation using a two-compartment model and confirmed that the transit time corrected ASL-CBF correlated well with PET-CBF in patients with chronic occlusive cerebral vascular disease. Moreover, we have proposed new vascular suppression method (DANTE), with which preliminary in vivo examination showed that the DANTE ASL technique had more homogenous vascular suppression effects than MSDE.
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