Usefulness of high spatial and temporal resplution dynamic contrast-enhanced MRI in the diagnosis of hepatocellular carcinoma

• Project/Area Number: 15K09917
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Shinshu University
• Principal Investigator: Fujinaga Yasunari 信州大学, 学術研究院医学系, 准教授 (70334901)
• Co-Investigator(Kenkyū-buntansha): 黒住 昌弘 信州大学, 学術研究院医学系(医学部附属病院), 助教 (30377642)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 肝細胞癌 / ダイナミックMRI / radial VIBE / 経皮的肝動脈造影下cine CT / コロナ濃染 / 腫瘍周囲低信号帯 / transient severe motion / 再発率

Outline of Final Research Achievements

The aim of this study was to develop a new dynamic contrast-enhanced MR sequence which had high-spatial and -temporal resolution and was useful for diagnosing hepatocellular carcinoma (HCC) .
We evaluated that radial VIBE with k-space weighted image reconstruction (r-VIBE-KWIC) minimized artifact and produced high-quality and high temporal resolution images compared with Cartesian VIBE. In addition, it has diagnostic potential comparable with that of dynamic CT during hepatic arteriography in the hemodynamic evaluation of hypervascular HCC. Usefulness of r-VIBE-KWIC for differentiating between HCC and cholangiocarcinoma is under consideration.

Research Products

• [Journal Article] Evaluation of hemodynamic imaging findings of hypervascular hepatocellular carcinoma: comparison between dynamic contrast-enhanced magnetic resonance imaging using radial volumetric imaging breath-hold examination with k-space-weighted image contrast reconstruction and dynamic computed tomography during hepatic arteriography (2018)
  • Author(s): Kurozumi M, Fujinaga Y, Kitou Y, Yamada A, Ohya A, Adachi Y, Tsukahara Y, Nickel MD, Maruyama K, Uehara T, Miyagawa SI, Kadoya M
  • Journal Title: Japanese Journal of Radiology Volume: 36 Issue: 4 Pages: 295-302
  • DOI: 10.1007/s11604-018-0720-9
  • NAID: 120007099788
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 圧縮センシングを用いた肝ダイナミックMRI (2018)
  • Author(s): 藤永康成，木藤善弘，愛多地康雄，丸山克哉，川口浩和，角谷眞澄
  • Journal Title: INNERVISION Volume: 33 Pages: 23-25
• [Journal Article] Advantages of radial volumetric breath-hold examination (VIBE) with k-space weighted image contrast reconstruction (KWIC) over Cartesian VIBE in liver imaging of volunteers simulating inadequate or no breath-holding ability (2015)
  • Author(s): Fujinaga Y, Kitou Y, Ohya A, Adachi Y, Tamaru N, Shiobara A, Ueda H, Nickel MD, Maruyama K, Kadoya M
  • Journal Title: European Radiology Volume: - Issue: 8 Pages: 2790-2797
  • DOI: 10.1007/s00330-015-4103-7
  • NAID: 120007099789
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] Current MR Imaging of hepatocellular carcinoma (2017)
  • Author(s): Yasunari Fujinaga
  • Organizer: The 12th JSH Single Topic Conference in Kanazawa
  • Int'l Joint Research / Invited
• [Presentation] 高時間分解能ダイナミックMRI動脈優位相における肝癌周囲低信号帯に関する肝切除後の予後予測に関する検討 (2016)
  • Author(s): 藤永康成
  • Organizer: 第52回日本肝癌研究会
  • Place of Presentation: 東京（虎ノ門ヒルズフォーラム）
  • Year and Date: 2016-07-01