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Development of computer-assisted diagnosis of thoracic diseases using a large scale 3D-CT image database

Research Project

Project/Area Number 15K09919
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionNagoya University

Principal Investigator

Shingo Iwano  名古屋大学, 医学系研究科, 准教授 (90335034)

Co-Investigator(Kenkyū-buntansha) 本谷 秀堅  名古屋工業大学, 工学(系)研究科(研究院), 教授 (60282688)
木戸 尚治  山口大学, 大学院創成科学研究科, 教授 (90314814)
Project Period (FY) 2015-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords胸部CT / 肺癌 / コンピュータ支援診断 / 原発性肺癌 / 3D-CT / PET/CT / 3D-CT / TNM分類 / 予後予測 / CAD / 医用画像工学 / 人工知能
Outline of Final Research Achievements

In this study, we developed a new CAD system that integrates chest 3D-CT and FDG-PET/CT images with medical information, and developed a new CAD system for the prognosis of primary lung cancer, and obtained the following four findings: 1) Accurate prognosis can be predicted by adding PET/CT quantitative data to CT images in the clinical staging of lung cancer; 2) Accurate prognosis can be predicted by 3D image analysis of Part-solid type lung cancer by CAD; 3) MTD (Metabolic Tumor Diameter) is developed as a new quantitative index of PET/CT, which is consistent with the staging of early stage lung cancer; 4) Ground-glass opacity on CT findings of lung cancer is related to prognosis.

Academic Significance and Societal Importance of the Research Achievements

従来の原発性肺癌の病期分類・予後予測は手術で摘出した病理所見(病理病期分類)に基づいて行われてきた。
しかし近年、小型肺癌については定位放射線治療の成績が手術に匹敵するとの報告がなされるようになっており、臨床病期分類の精度向上が課題の1つであった。
本研究成果は、肺癌の予後予測に非侵襲的な検査である3次元CTとFDG-PET/CTが重要な役割を果たしており、それらによって従来よりも正確に臨床病期分類を行うことが可能となったことを明らかにした。

Report

(6 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (8 results)

All 2019 2018 2016

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 4 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Postoperative Recurrence of Clinical Early-Stage Non-Small Cell Lung Cancers: A Comparison Between Solid and Subsolid Nodules2019

    • Author(s)
      Iwano S, et al.
    • Journal Title

      Cancer Imaging

      Volume: 19 Issue: 1 Pages: 33-33

    • DOI

      10.1186/s40644-019-0219-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Utility of Metabolic Parameters on FDG PET/CT in the Classification of Early-Stage Lung Adenocarcinoma: Prediction of Pathological Invasive Size2019

    • Author(s)
      Iwano S, et al.
    • Journal Title

      Clin Nucl Med

      Volume: 44 Issue: 7 Pages: 560-565

    • DOI

      10.1097/rlu.0000000000002591

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] FDG PET/CT Overcomes Discordance Between Clinical and Pathologic TNM Classification of Small-size Primary Lung Cancer: Influence on Postoperative Prognosis2018

    • Author(s)
      Umakoshi Hiroyasu、Iwano Shingo、Yokoi Kohei、Ito Shinji、Ito Rintaro、Kawaguchi Koji、Fukui Takayuki、Naganawa Shinji
    • Journal Title

      Clinicar Lung Cancer

      Volume: 19 Issue: 1 Pages: e37-e45

    • DOI

      10.1016/j.cllc.2017.05.021

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Computer-aided Volumetry of Part-Solid Lung Cancers by Using CT: Solid Component Size Predicts Prognosis2018

    • Author(s)
      Kamiya Shinichiro、Iwano Shingo、Umakoshi Hiroyasu、Ito Rintaro、Shimamoto Hironori、Nakamura Shota、Naganawa Shinji
    • Journal Title

      Radiology

      Volume: 印刷中 Issue: 3 Pages: 172319-172319

    • DOI

      10.1148/radiol.2018172319

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Evaluation of locoregional invasiveness of small-sized non-small cell lung cancers by enhanced dual-energy computed tomography.2016

    • Author(s)
      Hironori Shimamoto, Shingo Iwano, Hiroyasu Umakoshi, Koji Kawaguchi, Shinji Naganawa
    • Journal Title

      Cancer Imaging.

      Volume: 16(1) Issue: 1 Pages: 18-18

    • DOI

      10.1186/s40644-016-0077-1

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] FDG-PET画像を用いた浸潤サイズの計測2018

    • Author(s)
      岩野信吾
    • Organizer
      第59回日本肺癌学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 造影dual-energy CTによる小型肺癌の局所浸潤評価2016

    • Author(s)
      島本宏矩、岩野信吾、馬越弘泰、長縄慎二
    • Organizer
      第75回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-04-14
    • Related Report
      2016 Research-status Report
  • [Presentation] Evaluation of locoregional invasiveness of small-sized lung cancers by enhanced dual-energy computed tomography.2016

    • Author(s)
      Shimamoto H, Iwano S, Naganawa S
    • Organizer
      ECR2016
    • Place of Presentation
      ウィーン、オーストリア
    • Year and Date
      2016-03-02
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2021-02-19  

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