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Improvement of MRI-based brain connectome with high-speed and high-precision denoising techniques

Research Project

Project/Area Number 15K09920
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionKyoto University

Principal Investigator

Oishi Naoya  京都大学, 健康長寿社会の総合医療開発ユニット, 特定講師 (40526878)

Co-Investigator(Kenkyū-buntansha) 杉原 玄一  京都大学, 医学研究科, 助教 (70402261)
藤原 宏志  京都大学, 情報学研究科, 准教授 (00362583)
鈴木 崇士  京都大学, 健康長寿社会の総合医療開発ユニット, 特定助教 (10572224)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsGPGPU / ノイズ除去 / コネクトーム / MRI / 脳 / non-local means / 深層学習
Outline of Final Research Achievements

A non-local means (NLM) filter has been proposed, which can effectively remove noise with preserving edge in return for computational burden. We have therefore developed an accelerating software of the 3D NLM filter by general-purpose graphics processing units (GPGPU), which enables massively parallel computing. In the study, we applied the software to human and animal brain MRI and demonstrated that it is useful for brain connectome which has been innovating in recent years.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (31 results)

All 2018 2017 2016 2015

All Journal Article (15 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 15 results,  Open Access: 6 results,  Acknowledgement Compliant: 5 results) Presentation (15 results) (of which Int'l Joint Research: 8 results,  Invited: 3 results) Book (1 results)

  • [Journal Article] 18F-FPYBF-2, a new F-18 labelled amyloid imaging PET tracer: biodistribution and radiation dosimetry assessment of first-in-man 18F-FPYBF-2 PET imaging2018

    • Author(s)
      Nishii Ryuichi、Higashi Tatsuya、Kagawa Shinya、Okuyama Chio、Kishibe Yoshihiko、Takahashi Masaaki、Okina Tomoko、Suzuki Norio、Hasegawa Hiroshi、Nagahama Yasuhiro、Ishizu Koichi、Oishi Naoya、Kimura Hiroyuki、Watanabe Hiroyuki、Ono Masahiro、Saji Hideo、Yamauchi Hiroshi
    • Journal Title

      Ann Nucl Med

      Volume: 32 Issue: 4 Pages: 256-263

    • DOI

      10.1007/s12149-018-1240-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 18F-FPYBF-2, a new F-18-labelled amyloid imaging PET tracer: first experience in 61 volunteers and 55 patients with dementia2018

    • Author(s)
      Higashi Tatsuya、Nishii Ryuichi、Kagawa Shinya、Kishibe Yoshihiko、Takahashi Masaaki、Okina Tomoko、Suzuki Norio、Hasegawa Hiroshi、Nagahama Yasuhiro、Ishizu Koichi、Oishi Naoya、Kimura Hiroyuki、Watanabe Hiroyuki、Ono Masahiro、Saji Hideo、Yamauchi Hiroshi
    • Journal Title

      Ann Nucl Med

      Volume: 32 Issue: 3 Pages: 206-216

    • DOI

      10.1007/s12149-018-1236-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alteration of Venous Drainage Route in Idiopathic Normal Pressure Hydrocephalus and Normal Aging2017

    • Author(s)
      Satow Takeshi、Aso Toshihiko、Nishida Sei、Komuro Taro、Ueno Tsukasa、Oishi Naoya、Nakagami Yukako、Odagiri Masashi、Kikuchi Takayuki、Yoshida Kazumichi、Ueda Keita、Kunieda Takeharu、Murai Toshiya、Miyamoto Susumu、Fukuyama Hidenao
    • Journal Title

      Frontiers in Aging Neuroscience

      Volume: 9 Pages: 387-387

    • DOI

      10.3389/fnagi.2017.00387

    • NAID

      120006533289

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Brain atrophy in the visual cortex and thalamus induced by severe stress in animal model2017

    • Author(s)
      Yoshii Takanobu、Oishi Naoya、Ikoma Kazuya、Nishimura Isao、Sakai Yuki、Matsuda Kenichi、Yamada Shunji、Tanaka Masaki、Kawata Mitsuhiro、Narumoto Jin、Fukui Kenji
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 12731-12731

    • DOI

      10.1038/s41598-017-12917-z

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Direct Numerical Computation of the Stationary Radiative Transport Equation on Modern Parallel Architectures2017

    • Author(s)
      Fujiwara Hiroshi、Oishi Naoya
    • Journal Title

      Proceedings of the The 16th International Symposium on Distributed Computing and Applications to Business, Engineering and Sciences

      Volume: 1 Pages: 29-32

    • DOI

      10.1109/dcabes.2017.62

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct Patterns of Cerebral Cortical Thinning in Schizophrenia: A Neuroimaging Data-Driven Approach2017

    • Author(s)
      Sugihara G, Oishi N, Son S, Kubota M, Takahashi H, Murai T
    • Journal Title

      Schizophrenia Bulletin

      Volume: in press

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A multicenter, randomized, placebo-controlled 1 trial for cilostazol in patients with MCI: the COMCID study protocol2016

    • Author(s)
      Saito S, Kojima S, Oishi N, Kakuta R, Maki T, Yasuno F, Nagatsuka K, Yamamoto H, Fukuyama H, Fukushima M, Ihara M
    • Journal Title

      Alzheimer's & Dementia: Translational Research & Clinical Interventions

      Volume: 2 Issue: 4 Pages: 250-257

    • DOI

      10.1016/j.trci.2016.10.001

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Visualization of heterogeneity and regional grading of gliomas by multiple features using magnetic resonance-based clustered images2016

    • Author(s)
      Inano R, Oishi N, Kunieda T, Arakawa Y, Kikuchi T, Fukuyama H, Miyamoto S.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 30344-30344

    • DOI

      10.1038/srep30344

    • NAID

      120005825907

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] In vivo detection of atherosclerotic plaque using non-contact and label-free near-infrared hyperspectral imaging2016

    • Author(s)
      Chihara H, Oishi N, Ishii A, Munemitsu T, Arai D, Ikeda H, Miyamoto S
    • Journal Title

      Atherosclerosis

      Volume: 250 Pages: 106-113

    • DOI

      10.1016/j.atherosclerosis.2016.04.029

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Prediction of Alzheimer's Disease in Amnestic Mild Cognitive Impairment Subtypes: Stratification Based on Imaging Biomarkers2016

    • Author(s)
      Ota K, Oishi N, Ito K, Fukuyama H, SEAD-J Study Group, for the Alzheimer's Disease Neuroimaging Initiative
    • Journal Title

      J Alzheimers Dis

      Volume: 52 Issue: 4 Pages: 1385-1401

    • DOI

      10.3233/jad-160145

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Gradual cerebral hypoperfusion in spontaneously hypertensive rats induces slowly evolving white matter abnormalities and impairs working memory2016

    • Author(s)
      Kitamura A, Saito S, Maki A, Ayaki T, Oishi N, Kalaria RN, Hattori Y, Yamamoto Y, Urushitani M, Horsburgh K, Fukuyama H, Takahashi R, Ihara M
    • Journal Title

      J Cereb Blood Flow Metab

      Volume: - Issue: 9 Pages: 1592-1602

    • DOI

      10.1177/0271678x15606717

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Gradual cerebral hypoperfusion in spontaneously hypertensive rats induces slowly evolving white matter abnormalities and impairs working memory2016

    • Author(s)
      Kitamura A, Saito S, Maki T, Oishi N, Ayaki T, Hattori Y, Yamamoto Y, Urushitani M, Kalaria R, Fukuyama H, Horsburgh K, Takahashi R, Ihara M.
    • Journal Title

      Journal of Cerebral Blood Flow & Metabolism

      Volume: in press

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Prediction of Alzheimer’s Disease in Amnestic Mild Cognitive Impairment Subtypes: Stratification Based on Imaging Biomarkers.2016

    • Author(s)
      Ota K, Oishi N, Ito K, Fukuyama H, SEAD-J Study Group, for the Alzheimer’s Disease Neuroimaging Initiative.
    • Journal Title

      J Alzheimers Dis

      Volume: in press

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Hypothalamic-Amygdalar-Brainstem Volume Reduction in a Patient with Narcolepsy Secondary to Diffuse Axonal Injury.2015

    • Author(s)
      Yassin W, Sugihara G, Oishi N, Kubota M, Ubukata S, Murai T, Ueda K.
    • Journal Title

      J Clin Sleep Med.

      Volume: 15 Issue: 05 Pages: 581-2

    • DOI

      10.5664/jcsm.4710

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effects of imaging modalities, brain atlases and feature selection on prediction of Alzheimer's disease.2015

    • Author(s)
      Ota K, Oishi N, Ito K, Fukuyama H, SEAD-J Study Group, for the Alzheimer’s Disease Neuroimaging Initiative.
    • Journal Title

      J Neurosci Methods

      Volume: 256 Pages: 168-183

    • DOI

      10.1016/j.jneumeth.2015.08.020

    • NAID

      120005676653

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Predicting Motor Recovery at One Week After Ischemic Stroke: a Combined Transcranial Magnetic Stimulation and MRI Study2017

    • Author(s)
      Takahashi Y, Oishi N, Mima T, Fukuyama H, Takahashi R, Toyoda K, Nagatsuka K, Ihara M
    • Organizer
      International Stroke Conference 2017
    • Place of Presentation
      Houston, USA
    • Year and Date
      2017-02-22
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Deep structural learning for classification of Alzheimer's disease2017

    • Author(s)
      Naoya Oishi, Hidenao Fukuyama
    • Organizer
      XXIII World Congress of Neurology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] モチベーションの脳機能イメージング2017

    • Author(s)
      大石直也
    • Organizer
      日本社会心理学会第58回大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Deep structural learning for diagnosis of Alzheimer's disease2017

    • Author(s)
      Naoya Oishi, Hidenao Fukuyama
    • Organizer
      第36回日本認知症学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] グリア細胞のイメージング -過去から未来-2017

    • Author(s)
      福山秀直、大石直也
    • Organizer
      次世代脳プロジェクト冬のシンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Nigrostriatal degeneration and altered cortico-striatal functional connectivity in REM sleep behavior disorder (RBD) with subtle motor dysfunction2017

    • Author(s)
      Gohei Yamada, Yoshino Ueki, Takuya Oguri, Naoya Oishi, Ayako Fukui, Meiho Nakayama, Noriyuki Matsukawa
    • Organizer
      XXIII World Congress of Neurology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Striatal dysfunction and diminished functional connectivity in idiopathic REM sleep behavior disorder with subtle motor alteration2017

    • Author(s)
      Gohei Yamada, Yoshino Ueki, Takuya Oguri, Naoya Oishi, Ayako Fukui, Meiho Nakayama, Noriyuki Matsukawa
    • Organizer
      World Sleep 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Altered cortico-striatal functional connectivity in REM sleep behavior disorder with subtle motor dysfunction2017

    • Author(s)
      Gohei Yamada, Yoshino Ueki, Takuya Oguri, Naoya Oishi, Ayako Fukui, Meiho Nakayama, Noriyuki Matsukawa
    • Organizer
      47th ANNUAL MEETING NEUROSCIENCE 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neural basis of cognitive impairments in patients with diffuse axonal injury2016

    • Author(s)
      Ubukata S, Oishi N, Sugihara G, Yassin W, Aso T, Fukuyama H, Murai T, Ueda K
    • Organizer
      46th ANNUAL MEETING NEUROSCIENCE 2016
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of non-local means denoising on MRI-based structural connectome in Alzheimer's disease2016

    • Author(s)
      Oishi N, Fukuyama H
    • Organizer
      第57回日本神経学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-18
    • Related Report
      2016 Research-status Report
  • [Presentation] 優位半球の左右差における言語活動時の半球間結合性の可視化2016

    • Author(s)
      西田 誠、大石 直也、高橋 由紀、稲田 拓、中江 卓郎、稲野 理賀、丹治 正大、峰晴 陽平、舟木 健史、武信 洋平、菊池 隆幸、荒川 芳輝、吉田 和道、岡田 知久、國枝 武治、高木 康志、富樫 かおり、福山 秀直、宮本 享
    • Organizer
      第55回日本定位・機能神経外科学会
    • Place of Presentation
      仙台
    • Year and Date
      2016-01-22
    • Related Report
      2015 Research-status Report
  • [Presentation] Inverse problems in emission tomography2015

    • Author(s)
      Naoya Oishi
    • Organizer
      Mathematical Backgrounds and Future Progress of Practical Inverse Problems
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2015-11-10
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Stratification of MCI with Imaging Biomarkers Improves Outcome Prediction2015

    • Author(s)
      Naoya Oishi, Kenichi Ota, Kengo Ito, Hidenao Fukuyama, SEAD-J Study Group
    • Organizer
      第34回日本認知症学会学術集会
    • Place of Presentation
      青森
    • Year and Date
      2015-10-02
    • Related Report
      2015 Research-status Report
  • [Presentation] Axonal Fiber Connectivity in Schizophrenia: A Graph Theoretical Analysis in a Japanese Sample2015

    • Author(s)
      Yujiro Yoshihara, Naoya Oishi, Genichi Sugihara, Toshiya Murai
    • Organizer
      Organization for Human Brain Mapping 2015
    • Place of Presentation
      Honolulu, USA
    • Year and Date
      2015-06-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Prediction of MCI to AD conversion via gray and white matter structural changes2015

    • Author(s)
      Naoya Oishi, Chihiro Namiki, Hidenao Fukuyama
    • Organizer
      第56回日本神経学会総会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-20
    • Related Report
      2015 Research-status Report
  • [Book] Mathematical Backgrounds and Future Progress of Practical Inverse Problems. Mathematics for Industry Research No.52016

    • Author(s)
      Oishi N.
    • Total Pages
      233
    • Publisher
      Institute of Mathematics for Industry, Kyushu University
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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