Improvement of MRI-based brain connectome with high-speed and high-precision denoising techniques

• Project/Area Number: 15K09920
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyoto University
• Principal Investigator: Oishi Naoya 京都大学, 健康長寿社会の総合医療開発ユニット, 特定講師 (40526878)
• Co-Investigator(Kenkyū-buntansha): 杉原 玄一 京都大学, 医学研究科, 助教 (70402261) ; 藤原 宏志 京都大学, 情報学研究科, 准教授 (00362583) ; 鈴木 崇士 京都大学, 健康長寿社会の総合医療開発ユニット, 特定助教 (10572224)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: GPGPU / ノイズ除去 / コネクトーム / MRI / 脳 / non-local means / 深層学習

Outline of Final Research Achievements

A non-local means (NLM) filter has been proposed, which can effectively remove noise with preserving edge in return for computational burden. We have therefore developed an accelerating software of the 3D NLM filter by general-purpose graphics processing units (GPGPU), which enables massively parallel computing. In the study, we applied the software to human and animal brain MRI and demonstrated that it is useful for brain connectome which has been innovating in recent years.

Research Products

• [Journal Article] 18F-FPYBF-2, a new F-18 labelled amyloid imaging PET tracer: biodistribution and radiation dosimetry assessment of first-in-man 18F-FPYBF-2 PET imaging (2018)
  • Author(s): Nishii Ryuichi、Higashi Tatsuya、Kagawa Shinya、Okuyama Chio、Kishibe Yoshihiko、Takahashi Masaaki、Okina Tomoko、Suzuki Norio、Hasegawa Hiroshi、Nagahama Yasuhiro、Ishizu Koichi、Oishi Naoya、Kimura Hiroyuki、Watanabe Hiroyuki、Ono Masahiro、Saji Hideo、Yamauchi Hiroshi
  • Journal Title: Ann Nucl Med Volume: 32 Issue: 4 Pages: 256-263
  • DOI: 10.1007/s12149-018-1240-5
  • Peer Reviewed / Open Access
• [Journal Article] 18F-FPYBF-2, a new F-18-labelled amyloid imaging PET tracer: first experience in 61 volunteers and 55 patients with dementia (2018)
  • Author(s): Higashi Tatsuya、Nishii Ryuichi、Kagawa Shinya、Kishibe Yoshihiko、Takahashi Masaaki、Okina Tomoko、Suzuki Norio、Hasegawa Hiroshi、Nagahama Yasuhiro、Ishizu Koichi、Oishi Naoya、Kimura Hiroyuki、Watanabe Hiroyuki、Ono Masahiro、Saji Hideo、Yamauchi Hiroshi
  • Journal Title: Ann Nucl Med Volume: 32 Issue: 3 Pages: 206-216
  • DOI: 10.1007/s12149-018-1236-1
  • Peer Reviewed / Open Access
• [Journal Article] Alteration of Venous Drainage Route in Idiopathic Normal Pressure Hydrocephalus and Normal Aging (2017)
  • Author(s): Satow Takeshi、Aso Toshihiko、Nishida Sei、Komuro Taro、Ueno Tsukasa、Oishi Naoya、Nakagami Yukako、Odagiri Masashi、Kikuchi Takayuki、Yoshida Kazumichi、Ueda Keita、Kunieda Takeharu、Murai Toshiya、Miyamoto Susumu、Fukuyama Hidenao
  • Journal Title: Frontiers in Aging Neuroscience Volume: 9 Pages: 387-387
  • DOI: 10.3389/fnagi.2017.00387
  • NAID: 120006533289
  • Peer Reviewed / Open Access
• [Journal Article] Brain atrophy in the visual cortex and thalamus induced by severe stress in animal model (2017)
  • Author(s): Yoshii Takanobu、Oishi Naoya、Ikoma Kazuya、Nishimura Isao、Sakai Yuki、Matsuda Kenichi、Yamada Shunji、Tanaka Masaki、Kawata Mitsuhiro、Narumoto Jin、Fukui Kenji
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 12731-12731
  • DOI: 10.1038/s41598-017-12917-z
  • Peer Reviewed / Open Access
• [Journal Article] Direct Numerical Computation of the Stationary Radiative Transport Equation on Modern Parallel Architectures (2017)
  • Author(s): Fujiwara Hiroshi、Oishi Naoya
  • Journal Title: Proceedings of the The 16th International Symposium on Distributed Computing and Applications to Business, Engineering and Sciences Volume: 1 Pages: 29-32
  • DOI: 10.1109/dcabes.2017.62
  • Peer Reviewed
• [Journal Article] Distinct Patterns of Cerebral Cortical Thinning in Schizophrenia: A Neuroimaging Data-Driven Approach (2017)
  • Author(s): Sugihara G, Oishi N, Son S, Kubota M, Takahashi H, Murai T
  • Journal Title: Schizophrenia Bulletin Volume: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A multicenter, randomized, placebo-controlled 1 trial for cilostazol in patients with MCI: the COMCID study protocol (2016)
  • Author(s): Saito S, Kojima S, Oishi N, Kakuta R, Maki T, Yasuno F, Nagatsuka K, Yamamoto H, Fukuyama H, Fukushima M, Ihara M
  • Journal Title: Alzheimer's & Dementia: Translational Research & Clinical Interventions Volume: 2 Issue: 4 Pages: 250-257
  • DOI: 10.1016/j.trci.2016.10.001
  • Peer Reviewed / Open Access
• [Journal Article] Visualization of heterogeneity and regional grading of gliomas by multiple features using magnetic resonance-based clustered images (2016)
  • Author(s): Inano R, Oishi N, Kunieda T, Arakawa Y, Kikuchi T, Fukuyama H, Miyamoto S.
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 30344-30344
  • DOI: 10.1038/srep30344
  • NAID: 120005825907
  • Peer Reviewed / Open Access
• [Journal Article] In vivo detection of atherosclerotic plaque using non-contact and label-free near-infrared hyperspectral imaging (2016)
  • Author(s): Chihara H, Oishi N, Ishii A, Munemitsu T, Arai D, Ikeda H, Miyamoto S
  • Journal Title: Atherosclerosis Volume: 250 Pages: 106-113
  • DOI: 10.1016/j.atherosclerosis.2016.04.029
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Prediction of Alzheimer's Disease in Amnestic Mild Cognitive Impairment Subtypes: Stratification Based on Imaging Biomarkers (2016)
  • Author(s): Ota K, Oishi N, Ito K, Fukuyama H, SEAD-J Study Group, for the Alzheimer's Disease Neuroimaging Initiative
  • Journal Title: J Alzheimers Dis Volume: 52 Issue: 4 Pages: 1385-1401
  • DOI: 10.3233/jad-160145
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Gradual cerebral hypoperfusion in spontaneously hypertensive rats induces slowly evolving white matter abnormalities and impairs working memory (2016)
  • Author(s): Kitamura A, Saito S, Maki A, Ayaki T, Oishi N, Kalaria RN, Hattori Y, Yamamoto Y, Urushitani M, Horsburgh K, Fukuyama H, Takahashi R, Ihara M
  • Journal Title: J Cereb Blood Flow Metab Volume: - Issue: 9 Pages: 1592-1602
  • DOI: 10.1177/0271678x15606717
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Gradual cerebral hypoperfusion in spontaneously hypertensive rats induces slowly evolving white matter abnormalities and impairs working memory (2016)
  • Author(s): Kitamura A, Saito S, Maki T, Oishi N, Ayaki T, Hattori Y, Yamamoto Y, Urushitani M, Kalaria R, Fukuyama H, Horsburgh K, Takahashi R, Ihara M.
  • Journal Title: Journal of Cerebral Blood Flow & Metabolism Volume: in press
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Prediction of Alzheimer’s Disease in Amnestic Mild Cognitive Impairment Subtypes: Stratification Based on Imaging Biomarkers. (2016)
  • Author(s): Ota K, Oishi N, Ito K, Fukuyama H, SEAD-J Study Group, for the Alzheimer’s Disease Neuroimaging Initiative.
  • Journal Title: J Alzheimers Dis Volume: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Hypothalamic-Amygdalar-Brainstem Volume Reduction in a Patient with Narcolepsy Secondary to Diffuse Axonal Injury. (2015)
  • Author(s): Yassin W, Sugihara G, Oishi N, Kubota M, Ubukata S, Murai T, Ueda K.
  • Journal Title: J Clin Sleep Med. Volume: 15 Issue: 05 Pages: 581-2
  • DOI: 10.5664/jcsm.4710
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effects of imaging modalities, brain atlases and feature selection on prediction of Alzheimer's disease. (2015)
  • Author(s): Ota K, Oishi N, Ito K, Fukuyama H, SEAD-J Study Group, for the Alzheimer’s Disease Neuroimaging Initiative.
  • Journal Title: J Neurosci Methods Volume: 256 Pages: 168-183
  • DOI: 10.1016/j.jneumeth.2015.08.020
  • NAID: 120005676653
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Predicting Motor Recovery at One Week After Ischemic Stroke: a Combined Transcranial Magnetic Stimulation and MRI Study (2017)
  • Author(s): Takahashi Y, Oishi N, Mima T, Fukuyama H, Takahashi R, Toyoda K, Nagatsuka K, Ihara M
  • Organizer: International Stroke Conference 2017
  • Place of Presentation: Houston, USA
  • Year and Date: 2017-02-22
  • Int'l Joint Research
• [Presentation] Deep structural learning for classification of Alzheimer's disease (2017)
  • Author(s): Naoya Oishi, Hidenao Fukuyama
  • Organizer: XXIII World Congress of Neurology
  • Int'l Joint Research
• [Presentation] モチベーションの脳機能イメージング (2017)
  • Author(s): 大石直也
  • Organizer: 日本社会心理学会第58回大会
  • Invited
• [Presentation] Deep structural learning for diagnosis of Alzheimer's disease (2017)
  • Author(s): Naoya Oishi, Hidenao Fukuyama
  • Organizer: 第36回日本認知症学会学術集会
• [Presentation] グリア細胞のイメージング -過去から未来- (2017)
  • Author(s): 福山秀直、大石直也
  • Organizer: 次世代脳プロジェクト冬のシンポジウム
  • Invited
• [Presentation] Nigrostriatal degeneration and altered cortico-striatal functional connectivity in REM sleep behavior disorder (RBD) with subtle motor dysfunction (2017)
  • Author(s): Gohei Yamada, Yoshino Ueki, Takuya Oguri, Naoya Oishi, Ayako Fukui, Meiho Nakayama, Noriyuki Matsukawa
  • Organizer: XXIII World Congress of Neurology
  • Int'l Joint Research
• [Presentation] Striatal dysfunction and diminished functional connectivity in idiopathic REM sleep behavior disorder with subtle motor alteration (2017)
  • Author(s): Gohei Yamada, Yoshino Ueki, Takuya Oguri, Naoya Oishi, Ayako Fukui, Meiho Nakayama, Noriyuki Matsukawa
  • Organizer: World Sleep 2017
  • Int'l Joint Research
• [Presentation] Altered cortico-striatal functional connectivity in REM sleep behavior disorder with subtle motor dysfunction (2017)
  • Author(s): Gohei Yamada, Yoshino Ueki, Takuya Oguri, Naoya Oishi, Ayako Fukui, Meiho Nakayama, Noriyuki Matsukawa
  • Organizer: 47th ANNUAL MEETING NEUROSCIENCE 2017
  • Int'l Joint Research
• [Presentation] Neural basis of cognitive impairments in patients with diffuse axonal injury (2016)
  • Author(s): Ubukata S, Oishi N, Sugihara G, Yassin W, Aso T, Fukuyama H, Murai T, Ueda K
  • Organizer: 46th ANNUAL MEETING NEUROSCIENCE 2016
  • Place of Presentation: San Diego, USA
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Effect of non-local means denoising on MRI-based structural connectome in Alzheimer's disease (2016)
  • Author(s): Oishi N, Fukuyama H
  • Organizer: 第57回日本神経学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18
• [Presentation] 優位半球の左右差における言語活動時の半球間結合性の可視化 (2016)
  • Author(s): 西田 誠、大石 直也、高橋 由紀、稲田 拓、中江 卓郎、稲野 理賀、丹治 正大、峰晴 陽平、舟木 健史、武信 洋平、菊池 隆幸、荒川 芳輝、吉田 和道、岡田 知久、國枝 武治、高木 康志、富樫 かおり、福山 秀直、宮本 享
  • Organizer: 第55回日本定位・機能神経外科学会
  • Place of Presentation: 仙台
  • Year and Date: 2016-01-22
• [Presentation] Inverse problems in emission tomography (2015)
  • Author(s): Naoya Oishi
  • Organizer: Mathematical Backgrounds and Future Progress of Practical Inverse Problems
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2015-11-10
  • Int'l Joint Research / Invited
• [Presentation] Stratification of MCI with Imaging Biomarkers Improves Outcome Prediction (2015)
  • Author(s): Naoya Oishi, Kenichi Ota, Kengo Ito, Hidenao Fukuyama, SEAD-J Study Group
  • Organizer: 第34回日本認知症学会学術集会
  • Place of Presentation: 青森
  • Year and Date: 2015-10-02
• [Presentation] Axonal Fiber Connectivity in Schizophrenia: A Graph Theoretical Analysis in a Japanese Sample (2015)
  • Author(s): Yujiro Yoshihara, Naoya Oishi, Genichi Sugihara, Toshiya Murai
  • Organizer: Organization for Human Brain Mapping 2015
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2015-06-14
  • Int'l Joint Research
• [Presentation] Prediction of MCI to AD conversion via gray and white matter structural changes (2015)
  • Author(s): Naoya Oishi, Chihiro Namiki, Hidenao Fukuyama
  • Organizer: 第56回日本神経学会総会
  • Place of Presentation: 新潟
  • Year and Date: 2015-05-20
• [Book] Mathematical Backgrounds and Future Progress of Practical Inverse Problems. Mathematics for Industry Research No.5 (2016)
  • Author(s): Oishi N.
  • Total Pages: 233
  • Publisher: Institute of Mathematics for Industry, Kyushu University