Non-contrast breast MRI using molecular imaging of the breast with CEST-MRI

• Project/Area Number: 15K09921
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyoto University
• Principal Investigator: KATAOKA MASAKO 京都大学, 医学研究科, 助教 (10611577)
• Co-Investigator(Kenkyū-buntansha): 金尾 昌太郎 京都大学, 医学研究科, 助教 (80542216)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: Breast cancer / MRI / CEST / non contrast / Breast / Cancer

Outline of Final Research Achievements

Amide proton transfer(APT) Chemical Exchange Saturation Transfer（CEST）MRI is a state- of-the-art technique to detect low concentration amide molecule, and thus can indicate the concentration of mobile protein in our body. We hypothesized that APT CEST can reveal new information. Our result suggested that “hyperintensity rim on CEST MRI” is characteristic to the breast cancer. The rim may be seen in the pre treatment image and disappear. We also developed a quick version of CEST-MRI. The results will be presented in the coming academic meeting.

Research Products

• [Journal Article] The Value of Lesion Size as an Adjunct to the BI-RADS-MRI 2013 Descriptors in the Diagnosis of Solitary Breast Masses (2018)
  • Author(s): Kawai M, Kataoka M, Kanao S, Iima M, Onishi N, Ohashi A, Sakaguchi R, Toi M, Togashi K.
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 17 Issue: 3 Pages: 203-210
  • DOI: 10.2463/mrms.mp.2017-0024
  • NAID: 130007403794
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed
• [Journal Article] Differentiating benign and malignant inflammatory breast lesions: Value of T2 weighted and diffusion weighted MR images (2018)
  • Author(s): Shotaro Kanao, Masako Kataoka, Mami Iima, Debra Masako Ikeda, Masakazu Toi, Kaori Togashi
  • Journal Title: Magnetic Resonance Imaging Volume: 50 Pages: 38-44
  • DOI: 10.1016/j.mri.2018.03.012
  • Peer Reviewed
• [Presentation] Synthetic biomarkers using IVIM and non-Gaussian diffusion MRI: diagnostic performance and comparison with BI-RADS categories in differentiation of malignant/ benign breast tumors (2017)
  • Author(s): Iima M, Kataoka M, Kanao S, Onishi N, Kawai M, Ohashi A, Sakaguchi R, Ohno AK, Togashi K.
  • Organizer: European Congress of Radiology
  • Int'l Joint Research
• [Presentation] Quantitative non-Gaussian diffusion and IVIM MRI: Correlation between synthetic parameters and breast cancer biomarkers (2017)
  • Author(s): Iima M, Kataoka M, Kanao S, Onishi N, Kawai M, Ohashi A , Sakaguchi R, Kishimoto AO, Toi M, Togashi K
  • Organizer: The 25th Annual Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine
  • Int'l Joint Research
• [Presentation] How to Best Utilize T2-weighted MR Images of the Breast: Diagnostic Algorithm of T2-high SI area based on Location, Enhancement Pattern, and ADC Value. (2016)
  • Author(s): Onishi N, Kataoka M, Kanao S, Kawai M, Toi M, Iima M, Ohashi A, Sakaguchi R, Kishimoto O A. Togashi K
  • Organizer: Radiological Society of North America
  • Place of Presentation: Chicago, IL, USA
  • Year and Date: 2016-11-27
  • Int'l Joint Research
• [Presentation] How to Make Use of Non-fat-suppressed Precontrast T1-weighed Image in Breast MRI: Systematic Approach to Diagnosis with the Emphasis of Fat Signal Intensity (2016)
  • Author(s): Kawai M, Kataoka M, Kanao S, Onishi N, Iima M, Ohashi A, Sakaguchi R, Kishimoto O A, Toi M, Togashi K.
  • Organizer: Radiological Society of North America
  • Place of Presentation: Chicago, IL, USA
  • Year and Date: 2016-11-27
  • Int'l Joint Research
• [Presentation] RESOLVEを用いた高分解能拡散強調画像による腫瘍の治療前評価：高分解能造影ダイナミック画像との比較 (2016)
  • Author(s): 片岡正子 金尾昌太郎 飯間麻美 大西奈都子、河合真喜子、大橋茜、阪口怜奈、戸井雅和 富樫かおり
  • Organizer: 第24回日本乳癌学会学術総会 東京2016.6.16-18
  • Place of Presentation: 東京
  • Year and Date: 2016-06-16
  • Int'l Joint Research
• [Presentation] Amide proton transfer (APT) imaging of breast cancer at 3T MRI: a pilot study (2016)
  • Author(s): Onishi N, Kataoka M, Kanao S, Iima M, Kawai M, Ohashi A, Murata K, Schmitt B, Togashi K
  • Organizer: The 24th Annual Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Singapole
  • Year and Date: 2016-05-09
  • Int'l Joint Research
• [Presentation] High resolution diffusion-weighted MRI with readout-segmented echo-planar imaging and computed DWI as a potential alternative of high resolution dynamic contrast-enhanced MRI in evaluating breast cancer. (2016)
  • Author(s): Kataoka M, Kanao S, Iima M, Onishi N, Kawai M, Ohashi A, Toi M, Togashi K.
  • Organizer: The 24th Annual Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Singapore
  • Year and Date: 2016-05-07
  • Int'l Joint Research
• [Presentation] Non-Gaussian Diffusion MRI in Evaluation of Early Treatment Effects during Neoadjuvant Treatment for Breast Cancer (2015)
  • Author(s): Iima M,Ogino R, Kataoka M, Nagao S, Kanao S, Ohashi A, Kawai M,Onishi N, Togashi K, Le Bihan D
  • Organizer: 第74回日本医学放射線学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2015-04-16