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Development of a new molecular image analysis method for quantitative evaluation of intratumoral apoptosis

Research Project

Project/Area Number 15K09924
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionOkayama University

Principal Investigator

Kuroda Masahiro  岡山大学, 保健学研究科, 教授 (50225306)

Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
KeywordsMRI / バイオファントム / ADC / アポトーシス / 制限拡散
Outline of Final Research Achievements

Apoptosis quantitative imaging method (ASM method) for 3T MR device based on MRI diffusion weighted image was developed using RESOLVE method. The experiments using bio-phantoms containing cultured tumor cells clarified that the ASM method can analyze minute restricted diffusion like apoptotic bodies with high resolution on the order of 1 micrometer. The ASM method could visualize restricted diffusion as same as diffusion kurtosis imaging. The ASM method might be promising as a new imaging method for restricted diffusion like apoptotic bodies.

Academic Significance and Societal Importance of the Research Achievements

悪性腫瘍に対して分子標的薬剤などによる治療が有効な場合、腫瘍内に多くのアポトーシスが出現することが知られている。現在臨床で用いられるアポトーシス定量画像化手法はなく、今回、MRI拡散強調画像をベースとした3T MR装置用のアポトーシス定量撮像法(ASM法)を開発した。現在、臨床試験のための専用の画像解析ソフトウェアの開発を開始している。ASM法は、アポトーシス画像化手法として有望であり、今後早期に有用性を確認する臨床試験に入る予定である。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2018 2016

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] The Usefulness of Readout-Segmented Echo-Planar Imaging (RESOLVE) for Bio-phantom Imaging Using 3-Tesla Clinical MRI2018

    • Author(s)
      Yuuki Yoshimura, Masahiro Kuroda, Irfan Sugianto, Babatunde O. Bamgbose, Kanae Miyahara, Yuichi Ohmura, Akira Kurozumi, Toshi Matsushita, Seiichiro Ohno, Susumu Kanazawa, and Junichi Asaumi
    • Journal Title

      Acta Medica Okayama

      Volume: 72 Issue: 1 Pages: 53-59

    • DOI

      10.18926/AMO/55663

    • NAID

      120006398863

    • URL

      https://ousar.lib.okayama-u.ac.jp/55663

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Readout Segmented EPIを用いた臨床用3テスラMRIによるバイオファントム撮像の有効性2016

    • Author(s)
      吉村祐樹、黒田昌宏、Irfan Sugianto
    • Organizer
      第44回日本放射線技術学会秋季学術大会
    • Place of Presentation
      大宮ソニックシティ(埼玉県さいたま市)
    • Year and Date
      2016-10-14
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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