Chemical exchange saturation transfer (CEST) imaging of head and neck tumor

• Project/Area Number: 15K09928
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyushu University
• Principal Investigator: Kamitani Takeshi 九州大学, 大学病院, 助教 (20419534)
• Co-Investigator(Kenkyū-buntansha): 川波 哲 九州大学, 大学病院, 助教 (50330999) ; 長尾 充展 九州大学, 医学研究院, 准教授 (60533081) ; 栂尾 理 九州大学, 大学病院, 助教 (10452749) ; 山崎 誘三 九州大学, 大学病院, その他 (00643347) ; 山之内 寅彦 独立行政法人国立病院機構別府医療センター(臨床研究部), 臨床研究部, その他 (40748034) ; 藪内 英剛 九州大学, 医学研究院, 教授 (70380623) ; 日野 卓也 九州大学, 大学病院, 医員 (10807100) ; 亀井 俊佑 九州大学, 大学病院, 医員 (90778862) ; 進 政太郎 九州大学, 大学病院, 医員 (10794224) ; 本田 浩 九州大学, 大学病院, 教授 (90145433)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 耳下腺 / MRI / CEST / APT / 耳下腺腫瘍

Outline of Final Research Achievements

The mean amide proton transfer (APT) signal intensity of malignant parotid tumors was significantly higher than that of benign parotid tumors. Most of the malignant tumors showed APT signal intensities of 2% or more. The sensitivity and specificity were 77.8% and 65.0%, respectively. These results were presented at RSNA 2017.

Research Products

• [Presentation] Amide proton transfer (APT) imaging of parotid tumors: differentiation between malignant and benign tumors (2017)
  • Author(s): Takeshi Kamitani, Satoshi Kawanami, Koji Sagiyama, Osamu Togao, Yuzo Yamasaki, Hiroshi Honda, Takuya Hino, Ryuji Yasumatsu, Hidetake Yabuuchi
  • Organizer: 103rd Scientific Assembly and Annual Meeting of Radiological Society of North America
  • Int'l Joint Research
• [Presentation] MR Imaging of Parotid Gland Tumors: Added Value of Permeability MR Imaging (2016)
  • Author(s): H Yabuuchi, MD, Fukuoka, Fukuoka JAPAN; S Kawanami, MD; T Kamitani, MD; K Sagiyama, MD; Y Yamasaki, MD; H Honda, MD; et al.
  • Organizer: RSNA2016
  • Place of Presentation: シカゴ
  • Year and Date: 2016-11-27
  • Int'l Joint Research