| Project/Area Number |
15K09929
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
神谷 武志 九州大学, 大学病院, 助教 (20419534)
山之内 寅彦 九州大学, 大学病院, 医員 (40748034)
長尾 充展 九州大学, 医学研究院, 准教授 (60533081)
藪内 英剛 九州大学, 医学研究院, 教授 (70380623)
本田 浩 九州大学, 大学病院, 教授 (90145433)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | MRI / 心臓 / 酸素 / 心筋症 / BOLD / 線維化 / 肥大型心筋症 / 拡張型心筋咀湯 / 拡張型心筋症 |
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| Outline of Final Research Achievements |
We developed the novel oxygen-enhanced MRI protocol, and investigated the utility of T2*-weighted cardiac MRI, visualizing the difference of signals during normoxia (T2*air) and hyperoxia (T2*oxy) in cases with normal, hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). Oxygen-enhanced T2* cardiac magnetic resonance (CMR) showed the different delta T2* (T2*oxy - T2* air), reflecting myocardial blood-oxygen dependent (BOLD) effect. T2* was stable or shortened in HCM and normal due to vasoconstriction or hypo-perfusion, and in congestive heart failure (CHF) and DCM, respectively.
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