Development of oxygen-enhanced cardiac MRI
Project/Area Number |
15K09929
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | Kyushu University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
神谷 武志 九州大学, 大学病院, 助教 (20419534)
山之内 寅彦 九州大学, 大学病院, 医員 (40748034)
長尾 充展 九州大学, 医学研究院, 准教授 (60533081)
藪内 英剛 九州大学, 医学研究院, 教授 (70380623)
本田 浩 九州大学, 大学病院, 教授 (90145433)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | MRI / 心臓 / 酸素 / 心筋症 / BOLD / 線維化 / 肥大型心筋症 / 拡張型心筋咀湯 / 拡張型心筋症 |
Outline of Final Research Achievements |
We developed the novel oxygen-enhanced MRI protocol, and investigated the utility of T2*-weighted cardiac MRI, visualizing the difference of signals during normoxia (T2*air) and hyperoxia (T2*oxy) in cases with normal, hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). Oxygen-enhanced T2* cardiac magnetic resonance (CMR) showed the different delta T2* (T2*oxy - T2* air), reflecting myocardial blood-oxygen dependent (BOLD) effect. T2* was stable or shortened in HCM and normal due to vasoconstriction or hypo-perfusion, and in congestive heart failure (CHF) and DCM, respectively.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Quantification of myocardial oxygenation in heart failure using blood-oxygen-level-dependent T2* magnetic resonance imaging: Comparison with cardiopulmonary exercise test.2017
Author(s)
Nagao M, Yamasaki Y, Kawanami S, Kamitani T, Sagiyama K, Higo T, Ide T, Takemura A, Ishizaki U, Fukushima K, Watanabe Y, Honda H.
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Journal Title
Magn Reson Imaging
Volume: 39
Pages: 138-143
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Quantitative MR imaging in pulmonary hypertension: How to evaluate the hemodynamics and therapeutic effect.2016
Author(s)
Yamasaki Y, Kawanami S, Kamitani T, Sagiyama K , Kamei S , Hosokawa K, Horimoto K , Abe K , Yabuuchi H, Honda H
Organizer
102th Scientific Assembly and Annual Meeting of Radiological Society of North America.
Place of Presentation
Chicago, USA
Year and Date
2016-11-27
Related Report
Int'l Joint Research
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[Presentation] Oxygen-enhanced cardiac magnetic resonance imaging in cardiomyopathy.2016
Author(s)
Kawanami S, Nagao M, Yamasaki Y, Kamitani T, Yamanouchi T, Yuko Tanaka, Yabuuchi H, Ide T, Funatsu R, Watanabe Y, Honda H.
Organizer
1.24th Annual Meeting International Society for Magnetic Resonance in Medicine.
Place of Presentation
Singapore
Year and Date
2016-05-07
Related Report
Int'l Joint Research
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