Developement of new non-invasive method based on diffusion-weighted imaging for the radiographic diagnosis

• Project/Area Number: 15K09935
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Iwate Medical University
• Principal Investigator: Fujiwara Shunrou 岩手医科大学, 医学部, 助教 (60405842)
• Co-Investigator(Kenkyū-buntansha): 和田 司 岩手医科大学, 医学部, 准教授 (00275570) ; 別府 高明 岩手医科大学, 医学部, 教授 (70275543)
• Co-Investigator(Renkei-kenkyūsha): Ogasawara Kuniaki 岩手医科大学, 医学部, 教授 (00305989)
• Research Collaborator: Yoshioka Yoshichika ; Mori Yuki
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: MRI / 拡散強調 / DWI / intravoxel incoherent / 虚血 / chronic ischemia / diffusion / IVIM / rat / common carotid artery / occlusion / moyamoya disease / 脳虚血

Outline of Final Research Achievements

In the present study, we investigated about development of new radiographic diagnosis technique based on diffusion-weighted imaging (DWI) at ultra-high field magnetic resonance (MR) imaging system. In animal experiments, intravoxel incoherent motion (IVIM) based on DWI can non-invasively assess abnormal cerebral hemodynamic states in severe ischemic rats. We will apply the analytical technique for human research using clinical 7 Tesla MR scanner.

Research Products

• [Int'l Joint Research] フランス原子力庁サクレー支部Neurospin(フランス)
• [Journal Article] Preoperative brain temperature imaging on proton magnetic resonance spectroscopy predicts hemispheric ischemia during carotid endarterectomy for unilateral carotid stenosis with inadequate collateral blood flow. (2018)
  • Author(s): Tsutsui Shouta、Nanba Takamasa、Yoshioka Yoshichika、Sasaki Makoto、Fujiwara Shunrou、Kobayashi Masakazu、Yoshida Kenji、Miyoshi Kenya、Sato Shinpei、Ogasawara Kuniaki
  • Journal Title: Neurol Res Volume: 印刷中 Pages: 617-623
  • DOI: 10.1080/01616412.2018.1457130
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Preoperatively reduced cerebrovascular contractile reactivity to hypocapnia by hyperventilation is associated with cerebral hyperperfusion syndrome after arterial bypass surgery for adult patients with cerebral misery perfusion due to ischemic moyamoya disease (2018)
  • Author(s): Sato S, Kojima D, Shimada Y, Yoshida J, Fujimato K, Fujiwara S, Kobayashi M, Kubo Y, Yoshida K, Terasaki K, Tsutsui S, Miyoshi K, Ogasawara K.
  • Journal Title: J Cereb Blood Flow Metab. Volume: 1 Pages: 1021-1031
  • DOI: 10.1177/0271678x18757621
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Indirect MRI of 17 o-labeled water using steady-state sequences: Signal simulation and preclinical experiment. (2018)
  • Author(s): Nomura JI, Uwano I, Sasaki M, Kudo K, Yamashita F, Ito K, Fujiwara S, Kobayashi M, Ogasawara K.
  • Journal Title: J Magn Reson Imaging. Volume: 38(12) Pages: 1373-1379
  • DOI: 10.3174/ajnr.a5390
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Brain temperature imaging with multi-voxel proton magnetic resonance spectroscopy compared with cerebral blood flow and metabolism imaging on positron emission tomography in patients with unilateral chronic major cerebral artery steno-occlusive disease. (2017)
  • Author(s): Nanba T, Nishimoto H, Yoshioka Y, Murakami T, Sasaki M, Uwano I, Fujiwara S, Terasaki K, Ogasawara K
  • Journal Title: Neuroradiology Volume: 59 Pages: 923-935
  • DOI: 10.1007/s00234-017-1890-3
  • Peer Reviewed / Open Access
• [Journal Article] Relation between brain temperature and white matter damage in subacute carbon monoxide poisoning (2016)
  • Author(s): Fujiwara S, Yoshioka Y, Matsuda T, Nishimoto H, Ogawa A, Ogasawara K, Beppu T
  • Journal Title: Sci Rep Volume: 6 Pages: 36523-36523
  • DOI: 10.1038/srep36523
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Preoperative 3D FSE T1-Weighted MR Plaque Imaging for Severely Stenotic Cervical ICA: Accuracy of Predicting Emboli during Carotid Endarterectomy (2016)
  • Author(s): Ogasawara Y, Sato Y, Narumi S, Sasaki M, Fujiwara S, Kobayashi M, Yoshida K, Terayama Y, Ogasawara K
  • Journal Title: Int J Mol Sci Volume: 17
  • Peer Reviewed / Open Access
• [Journal Article] Effects of uncomplicated carotid endarterectomy on cognitive function and brain perfusion in patients with unilateral asymptomatic severe stenosis of the internal carotid artery by comparison with unoperated patients. (2016)
  • Author(s): Kojima D, Ogasawara K, Kobayashi M, Yoshida K, Kubo Y, Chida K, Oshida S, Yoshida J, Fujiwara S, Terasaki K
  • Journal Title: Neurol Res Volume: 7 Pages: 580-6
  • DOI: 10.1080/01616412.2016.1188551
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Brain temperature measured by 1H-magnetic resonance spectroscopy in acute and subacute carbon monoxide poisoning patients. (2016)
  • Author(s): Fujiwara S, Yoshioka Y, Matsuda T, Nishimoto H, Murakami T, Ogawa A, Ogasawara K, Beppu T
  • Journal Title: Neuroradiology Volume: 58 Pages: 27-32
  • DOI: 10.1007/s00234-015-1600-y
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Preoperative prediction of cerebral hyperperfusion after carotid endarterectomy using middle cerebral artery signal intensity in 1.5-tesla magnetic resonance angiography followed by cerebrovascular reactivity to acetazolamide using brain perfusion single-photon emission computed tomography (2016)
  • Author(s): Yoshida J, Ogasawara K, Chida K, Oikawa K, Matsumoto Y, Nomura JI, Ogasawara Y, Fujiwara S, Kobayashi M, Yoshida K, Terasaki K, Ogawa A
  • Journal Title: Neurol Res Volume: -
  • Peer Reviewed
• [Journal Article] くも膜下出血と脳梗塞を同時期に発症した前交通動脈に限局した解離と思われた1例 (2016)
  • Author(s): 小笠原靖, 久保慶高, 幸治孝裕, 佐藤由衣子, 藤原俊朗, 小笠原邦昭
  • Journal Title: Neurological Surgery 脳神経外科 Volume: 44 Pages: 233-238
  • Peer Reviewed
• [Presentation] 両側総頸動脈閉塞（BCCAO）ラットにおける超急性期の脳血管拡張および皮質内IVIM パラメータと予後との関係 (2017)
  • Author(s): 藤原 俊朗，森 勇樹，Daniela Martinez de la Mora，小笠原 邦昭，吉岡芳親
  • Organizer: 第24回東北脳循環カンファランス
  • Invited
• [Presentation] 両側総頸動脈閉塞モデル超急性期における脳血管拡張はラットの予後に関与するか？ (2017)
  • Author(s): 藤原 俊朗，森 勇樹，Daniela Martinez de la Mora，小笠原 邦昭，吉岡芳親
  • Organizer: 日本脳神経外科学会第76回学術総会
• [Presentation] 両側総頸動脈閉塞（BCCAO）ラットにおける超急性期の脳血管拡張および皮質内IVIM パラメータと予後との関係 (2017)
  • Author(s): 藤原 俊朗，森 勇樹，Daniela Martinez de la Mora，小笠原 邦昭，吉岡芳親
  • Organizer: 第45回日本磁気共鳴医学会大会
• [Presentation] 両側総頚動脈（BCCAO)ラットの予後関連因子は？～BCCAOモデル超急性期の脳血管拡張および皮質内IVIMパラメータ～ (2017)
  • Author(s): 藤原 俊朗，森 勇樹，Daniela Martinez de la Mora，小笠原 邦昭，吉岡芳親
  • Organizer: 脳循環代謝サマーキャンプ2017
• [Presentation] Prediction of outcome in bilateral common carotid artery occlusion rats by intravoxel incoherent motion analysis at 11.7 Tesla (2017)
  • Author(s): Fujiwara S, Mori Y, de la Mora DM, Ogasawara K, Yoshioka Y
  • Organizer: The 8th Korea-Japan Joint Stroke Conference
  • Int'l Joint Research
• [Presentation] Relation between brain temperature and cerebral perfusion and metabolism in human brain (2017)
  • Author(s): Fujiwara S, Beppu T, Ogasawara K, Yoshioka Y
  • Organizer: ISMRM 25th Annual Meeting and Exhibition 2017
  • Int'l Joint Research
• [Presentation] Prediction of outcome in bilateral common carotid artery occlusion (BCCAO) rats assessing the hyperacute cerebral hemodynamic changes using intravoxel incoherent motion (IVIM) analysis at 11.7 Tesla (2017)
  • Author(s): Fujiwara S, Mori Y, de la Mora DM, Ogasawara K, Yoshioka Y
  • Organizer: ISMRM 25th Annual Meeting and Exhibition 2017
  • Int'l Joint Research
• [Presentation] Brain temperature depends on degree of cerebral white matter damage in patients with subacute carbon monoxide poisoning (2017)
  • Author(s): Fujiwara S, Yoshioka Y, Matsuda T, Nishimoto H, Ogawa A, Ogasawara K, Beppu T
  • Organizer: 28th Symposium on Cerebral Blood Flow, Metabolism and Function (Brain 2017)
  • Int'l Joint Research
• [Presentation] Feasibility of 1H-MRS brain temperature map to detect hemodynamic abnormality in patients with unilateral chronic major cerebral artery steno-occlusive disease (2017)
  • Author(s): Namba T, Ogasawara K, Nishimoto H, Ishigaki D, Yoshioka Y, Murakami T, Sasaki M, Kobayashi M, Yoshida K, Uwano I, Fujiwara S, Terasaki K, and Ogawa A
  • Organizer: ISMRM 25th Annual Meeting and Exhibition 2017
  • Int'l Joint Research
• [Presentation] 両側総頸動脈閉塞ラットを用いたIVIM-DWIによるCBV測定法の検証 (2016)
  • Author(s): 藤原 俊朗，森 勇樹，Daniela Martinez de la Mora，小笠原 邦昭，吉岡芳親
  • Organizer: 第59回日本脳循環代謝学会学術集会
  • Place of Presentation: あわぎんホール、徳島
  • Year and Date: 2016-11-11
• [Presentation] 両側総頸動脈閉塞ラットを用いたIVIM-DWI脳循環代謝測定法の検証 (2016)
  • Author(s): 藤原 俊朗，森 勇樹，Daniela Martinez de la Mora，小笠原 邦昭，吉岡芳親
  • Organizer: 日本脳神経外科学会第75回学術総会
  • Place of Presentation: 福岡国際会議場、福岡
  • Year and Date: 2016-09-29
• [Presentation] IVIMを用いた両側総頸動脈閉塞ラットにおける脳血行動態異常の検出 (2016)
  • Author(s): 藤原 俊朗，森 勇樹，Daniela Martinez de la Mora，小笠原 邦昭，吉岡芳親
  • Organizer: 第44回日本磁気共鳴医学会大会
  • Place of Presentation: 大宮ソニックシティ、大宮
  • Year and Date: 2016-09-09
• [Presentation] Relationship between the position of the plaque signal intensity identified by 3D-FSE T1W MR plaque imaging and development of microembolic signals on transcranial Doppler during exposure procedure of carotid arteries in endarterectomy (2016)
  • Author(s): Ogasawara Y, Ogasawara K, Sato Y, Narumi S, Sasaki M, Kobayashi M, Fujiwara S, Yoshida K, Terayama Y, Ogawa A
  • Organizer: ISMRM 24th Annual Meeting and Exhibition 2016
  • Place of Presentation: Suntec Singapore Convention & Exhibition Centre, Singapore
  • Year and Date: 2016-05-07
  • Int'l Joint Research
• [Presentation] 17.2T動物用MRIを用いた拡散係数の拡散強調信号モデルへの依存性の検証 (2015)
  • Author(s): 藤原 俊朗, Boucif Djemai, Luisa Ciobanu, Denis Le Bihan
  • Organizer: 日本脳神経外科学会 第74回学術総会
  • Place of Presentation: ロイトン札幌他、札幌
  • Year and Date: 2015-10-14
• [Presentation] Assessment of brain temperature and white matter damage in subacute carbon monoxide poisoned patients using diffusion tensor imaging (2015)
  • Author(s): Fujiwara S, Yoshioka Y, Matsuda T, Nishimoto H, Murakami T, Ogawa A, Ogasawara K, Beppu T
  • Organizer: European Society of Neuroradiology, 38th Annual Meeting
  • Place of Presentation: Hotel Royal Continental, Naples, Italy
  • Year and Date: 2015-09-17
  • Int'l Joint Research
• [Presentation] 一酸化炭素中毒急性期・亜急性期における脳温 (2015)
  • Author(s): 藤原 俊朗、吉岡 芳親、松田 豪、西本 英明、村上 寿孝 小川 彰、小笠原 邦昭、別府 高明
  • Organizer: 第43回日本磁気共鳴医学会大会
  • Place of Presentation: 東京ドームホテル、東京
  • Year and Date: 2015-09-10
• [Presentation] Relationship between brain temperature and white matter damage in subacute carbon monoxide poisoned patients (2015)
  • Author(s): Fujiwara S, Yoshioka Y, Matsuda T, Nishimoto H, Murakami T, Nanba T, Ogawa A, Ogasawara K, Beppu T
  • Organizer: European Academy of Neurology,1st Congress
  • Place of Presentation: Messe Berlin, Berlin, Germany
  • Year and Date: 2015-06-20
  • Int'l Joint Research
• [Presentation] Diffusion-weighted thermometry using subarachnoid space cerebrospinal fluid in subacute carbon monoxide poisoning patients (2015)
  • Author(s): Fujiwara S, Yoshioka Y, Matsuda T, Nishimoto H, Murakami T, Ogawa A, Ogasawara K, Sasaki M, Beppu T
  • Organizer: International Society for Magnetic Resonance in Medicine, 23rd Annual Meeting and Exhibition 2015
  • Place of Presentation: Metro Tronto Convention Center, Toronto, Canada
  • Year and Date: 2015-05-30
  • Int'l Joint Research
• [Book] 日本脳ドック学会報 (2016)
  • Author(s): 藤原俊朗，小笠原邦昭
  • Total Pages: 1
  • Publisher: 一般社団法人 日本脳ドック学会
• [Remarks] フランス原子力庁サクレー支部超高磁場MRI研究センターNeurospin
  • URL: http://www.meteoreservice.com/neurospin/