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Flow assessment after minimal invasion therapy on the aorta and the pulmonary artery using 4D flow

Research Project

Project/Area Number 15K09936
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionKeio University

Principal Investigator

Okuda Shigeo  慶應義塾大学, 医学部(信濃町), 准教授 (30233456)

Co-Investigator(Kenkyū-buntansha) 川上 崇史  慶應義塾大学, 医学部(信濃町), 特任講師 (10348641)
陣崎 雅弘  慶應義塾大学, 医学部(信濃町), 教授 (80216259)
山田 祥岳  慶應義塾大学, 医学部(信濃町), 助教 (60383791)
Research Collaborator NAKAHARA Tadaki  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords4D Flow / MRI / フェーズコントラスト / 先天性心奇形 / フェーズコントラスト法 / 血流解析 / 4D flow / 血流 / 4D flow MRI / 慢性血栓塞栓肺高血圧症 / ファロー四徴症
Outline of Final Research Achievements

The 2D-PC is one of MRI techniques, which enables to measure the flow volume and velocity. In this study, we utilized 4D Flow which acquires flow information as a volume data in five minutes. The mean pulmonary arterial pressure was able to be estimated by measuring the duration of the vertices in the main pulmonary artery, exception of subjects with huge turbulence and/or marked regurgitation. The turbulence might be a cause of inaccuracy of the flow measurement. The observation of the flow pattern is indispensable to minimize the effect from the turbulence.

Academic Significance and Societal Importance of the Research Achievements

4D Flow法を5分間で撮像可能として、実臨床の撮像にも取り入れられるようになった。また、肺動脈内の血流計測はこれまでも重要視されていたが、渦流や螺旋流のような非層流が、計測結果に影響を及ぼすことが明らかとなった。血流パターンの情報がないまま撮像断面を決定することは誤差を生じる原因となるため、血流状態を 4D Flow で把握してから、測定断面を決定することが重要であることがわかった。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2019 2018 2017 2016

All Presentation (7 results) (of which Invited: 1 results)

  • [Presentation] e mismatch of flow between the main pulmonary artery and ascending aorta in patients after the repair surgery of tetralogy Fallot2019

    • Author(s)
      奥田茂男、鈴木達也、松本俊亮、陣崎雅弘、岩下憲行、前田潤、山岸敬幸
    • Organizer
      第78回日本医学放射線学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The Clinical Value of 4D Flow for Estimating mPAP in CTEPH Patients2018

    • Author(s)
      奥田茂男、山田祥岳、松本俊亮、鈴木達也、川上崇、陣崎雅弘
    • Organizer
      第77回日本医学放射線学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 心臓MRI-撮像の基本と将来展望2018

    • Author(s)
      奥田茂男
    • Organizer
      第54回医学放射線学会秋季臨床大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 4DFLOWを用いた肺動脈分枝血流評価:VENC設定の検討2018

    • Author(s)
      藤代力也、奥田茂男、野崎敦、布川喜嘉、鈴木達也、渡部敏男、藤原広和、陣崎雅弘
    • Organizer
      第46回日本磁気共鳴医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The Clinical Value of 4D Flow for Estimating mPAP in CTEPH Patients2018

    • Author(s)
      奥田茂男、山田祥岳、松本俊亮、鈴木達也、陣崎雅弘、川上崇
    • Organizer
      日本医学放射線学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Case Report: Aortic Shape and Blood Flow Pattern in Bicuspid Aortic Valve2017

    • Author(s)
      奥田茂男
    • Organizer
      日本心臓血管放射線研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] Study on scan parameters for 4D flow using kat-ARC2016

    • Author(s)
      藤代力也、奥田茂男 他
    • Organizer
      日本磁気共鳴医学会大会
    • Place of Presentation
      大宮ソニックシティ(埼玉県大宮市)
    • Year and Date
      2016-09-09
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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