Studying idiopathic normal pressure hydrocephalus with non-Gaussian diffusion imaging

• Project/Area Number: 15K09937
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Juntendo University
• Principal Investigator: Kamiya Kouhei 順天堂大学, 医学部, 非常勤助手 (30749825)
• Co-Investigator(Kenkyū-buntansha): 青木 茂樹 順天堂大学, 医学(系)研究科(研究院), 教授 (80222470)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: MRI / 拡散 / 拡散テンソルイメージング / 白質モデル / 特発性正常圧水頭症 / 脳 / 白質 / 拡散MRI / 正常圧水頭症 / 脳微細構造 / 治療後変化 / DKI / NODDI / 認知症 / 歩行障害 / パーキンソニズム

Outline of Final Research Achievements

The symptoms of idiopathic normal pressure hydrocephalus (iNPH) can be improved by shunt surgery, but prediction of treatment outcome is not established. We investigated changes of the corticospinal tract (CST) in iNPH before and after shunt surgery using diffusion microstructural imaging. The orientational coherence within the CSTs was higher in patients than in controls, and some normalization occurred after the surgery in patients indicating recovery from axon stretching. The estimated axon density was lower in patients than in controls but remained unchanged after the surgery, suggesting its potential as a marker for irreversible neuronal damage. Thus, diffusion MRI may distinguish between reversible and irreversible microstructural changes in iNPH. Our findings constitute a step towards a quantitative image biomarker that reflects pathological process and treatment outcomes of iNPH.

Research Products

• [Journal Article] Diffusion imaging of reversible and irreversible microstructural changes within the corticospinal tract in idiopathic normal pressure hydrocephalus. (2017)
  • Author(s): Kouhei Kamiya, Masaaki Hori, Ryohei Irie, Masakazu Miyajima, Madoka Nakajima, Koji Kamagata, Kouhei Tsuruta, Asami Saito, Misaki Nakazawa, Yuichi Suzuki, Harushi Mori, Akira Kunimatsu, Hajime Arai
  • Journal Title: NeuroImage Clinical Volume: 14 Pages: 663-671
  • DOI: 10.1016/j.nicl.2017.03.003
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Diffusional Kurtosis Imaging in Idiopathic Normal Pressure Hydrocephalus: Correlation with Severity of Cognitive Impairment. (2016)
  • Author(s): Kamiya K, Kamagata K, Miyajima M, Nakajima M, Hori M, Tsuruta K, Mori H, Kunimatsu A, Arai H, Aoki S, Ohtomo K.
  • Journal Title: Magn Reson Med Sci. Volume: ahead of print
  • NAID: 130005163443
• [Presentation] 特発性正常圧水頭症患者の白質線維におけるg-ratioの推定 (2018)
  • Author(s): 入江隆介，神谷昂平，堀正明，鈴木通真，鎌形康司，萩原彰文，武中祐樹，齊藤麻美，中島円 ，宮嶋雅一，青木茂樹
  • Organizer: 第47回日本神経放射線学会
• [Presentation] Diffusion microstructural imaging of reversible and irreversible changes within the corticospinal tract in idiopathic normal pressure hydrocephalus (2017)
  • Author(s): Kouhei Kamiya, Ryusuke Irie, Masaaki Hori, Masakazu Miyajima, Madoka Nakajima3, Harushi Mori, Akira Kunimatsu, Hajime Arai, Shigeki Aoki, Osamu Abe
  • Organizer: ISMRM 2017
  • Place of Presentation: ハワイ、アメリカ合衆国
  • Int'l Joint Research
• [Presentation] Impact of axon undulation on the estimation of dMRI metrics: Monte-Carlo simulation study on conventional diffusion tensor ellipsoids and NODDI. (2016)
  • Author(s): Kouhei Kamiya, Ryusuke Irie, Koji Kamagata, Masaaki Hori, Yuichi Suzuki, Harushi Mori, Akira Kunimatsu, Shigeki Aoki, Kuni Ohtomo.
  • Organizer: ECR 2016: 2-6 March 2016, Wien, Austria.
  • Place of Presentation: ウイーン、オーストリア
  • Year and Date: 2016-03-02
  • Int'l Joint Research
• [Presentation] Neurite Orientation Dispersion and Density Imaging could show the microstractual changes of Cortico-Spinal Tract in patients with Idiopathic Normal Pressure Hydrocephalus (2015)
  • Author(s): Kohei Tsuruta, Ryusuke Irie, Masaaki Hori, Issei Fukunaga, Yoshitaka Masutani3, Kouhei Kamiya, Akira Nishikori, Mariko Yoshida, Michimasa Suzuki, Masakazu Miyajima, Madoka Nakajima, Koji Kamagata, Hajime Arai, Atsushi Nakanishi, Shigeki Aoki, Atsushi Senoo.
  • Organizer: ISMRM 2015: 30 May – 5 June, Toronto, Canada.
  • Place of Presentation: トロント、カナダ
  • Year and Date: 2015-05-30
  • Int'l Joint Research
• [Funded Workshop] ISMRM 2016 (2016)
  • Place of Presentation: サンテックシティ、シンガポール
  • Year and Date: 2016-05-07