• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Investigation of prognostic values of neonatal MR quantitative parameters: DTI/DKI, VBM, and MRS

Research Project

Project/Area Number 15K09943
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionNational Institutes for Quantum and Radiological Science and Technology

Principal Investigator

Tomiyasu Moyoko  国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 分子イメージング診断治療研究部, 主幹研究員(任非) (10443079)

Co-Investigator(Kenkyū-buntansha) 相田 典子  地方独立行政法人神奈川県立病院機構神奈川県立こども医療センター(臨床研究所), 臨床研究所, 部長 (20586292)
柴崎 淳  地方独立行政法人神奈川県立病院機構神奈川県立こども医療センター(臨床研究所), 臨床研究所, 医長 (30540471)
Research Collaborator Enokizono Mikako  
Sato Masahiko  
Kusagiri Kohki  
Muramoto Yasutake  
Suzuki Yuichi  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsMRスペクトロスコピー / 新生児 / 代謝物濃度 / 脳容積 / DTI/DKI / 発達評価 / 診断 / MR画像 / VBM / DTI / MRS / GABA
Outline of Final Research Achievements

In 89 preterm infants with 23-35 weeks' gestational age and under 1500 g birthweight, the correlations of MR quantitative parameters (6 brain volumes, 6 volume to bodyweight at MR exam, 16 DKI estimates, and 10 metabolite concentrations) in neonatal period (postconceptional age (PCA), of 34-42 weeks) with the developmental quotient (DQ) on Kyoto Scale of Psychologic Development at age 1.5 years, and 3 years were investigated.
Some MR quantitative parameters showed positive significant correlations with PCA, such as intracranial volume, fractional anisotropy in the frontal white matter, and creatine concentration in the deep gray matter. In the comparisons of MR quantitative parameters between two subject groups (DQ>85, n=49, and DQ≦85, n=40; ANCOVA with covariate of PCA), there were no significant differences (P<0.001) both at age 1.5 years and 3 years .

Academic Significance and Societal Importance of the Research Achievements

本研究では、1歳半および3歳時での発達検査値(DQ>85, DQ≦85)で分けた2群間の脳MRパラメータ(脳容積・脳DKI推定値、脳内代謝物濃度)には有意差がみられず、新生児期の脳MRパラメータで1歳半および3歳時の発達の予後予測を行うことが難しいことが示唆された。
また、本研究では、対象者のフォローアップや発達評価は新生児科医、小児専門放射線科医、臨床心理士が行い、データ収集パラメータや解析は医学臨床を専門とする研究者が行っており、脳MRパラメータのデータの質は担保されている。そのため、これらの値は新生児期の発達を評価する際の有用な指標となり得ると考えられる。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (16 results)

All 2018 2017 2016 2015

All Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (12 results) (of which Int'l Joint Research: 3 results,  Invited: 3 results)

  • [Journal Article] Serial Magnetic Resonance Imaging and (1)H-Magnetic Resonance Spectroscopy in GABA Transaminase Deficiency: A Case Report.2018

    • Author(s)
      Ichikawa K, Tsuji M, Tsuyusaki Y, Tomiyasu M, Aida N, Goto T.
    • Journal Title

      JIMD Rep.

      Volume: Epub ahead of print Pages: 7-12

    • DOI

      10.1007/8904_2018_95

    • ISBN
      9783662586136, 9783662586143
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Changes in brain metabolite concentrations after neonatal hypoxic-ischemic encephalopathy2018

    • Author(s)
      Shibasaki J, Aida N, Morisaki N, Tomiyasu M, Nishi Y, Toyoshima K.
    • Journal Title

      Radiology

      Volume: 印刷中 Issue: 3 Pages: 840-848

    • DOI

      10.1148/radiol.2018172083

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] In vivo estimation of gamma-aminobutyric acid levels in the neonatal brain.2017

    • Author(s)
      Tomiyasu M, Aida N, Shibasaki J, Umeda M, Murata K, Heberlein K, Brown MA, Shimizu E, Tsuji H, Obata T.
    • Journal Title

      NMR in Biomedicine

      Volume: 30 Issue: 1

    • DOI

      10.1002/nbm.3666

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Normal lactate concentration range in the neonatal brain.2016

    • Author(s)
      Tomiyasu M, Aida N, Shibasaki J, Tachibana Y, Endo M, Nozawa K, Shimizu E, Tsuji H, Obata T.
    • Journal Title

      Magnetic Resonance Imaging

      Volume: 34 Issue: 9 Pages: 1269-1273

    • DOI

      10.1016/j.mri.2016.07.006

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Using MRI/S to Study Metabolic Signatures of Early Brain Development & Disease.2018

    • Author(s)
      Aida N, Tomiyasu, M
    • Organizer
      ISMRM, 26th annual meeting & exhibition
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ヒト脳の糖の観測:1H MRSの臨床への可能性2018

    • Author(s)
      富安もよこ
    • Organizer
      第30回臨床MR脳機能研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 早産児の新生児期における脳内代謝物濃度/脳容積/DKI解析値の発達の予後予測性の検討2018

    • Author(s)
      富安もよこ、相田典子、柴崎淳、榎園美香子、立花泰彦、川口拓之、佐藤公彦、草切孝貴、村本安武、北川藍、清水栄司、小畠隆行、東達也.
    • Organizer
      第46回日本磁気共鳴医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Edited MRS法を用いたin vivo 新生児脳のGABA信号の定量化2017

    • Author(s)
      富安もよこ、相田典子、柴崎淳、梅田雅宏、村田勝俊、Keith Heberlein、Mark A. Brown、清水栄司、辻比呂志、小畠隆行
    • Organizer
      第29回臨床MR脳機能研究会.東京.2017.4.8.
    • Related Report
      2017 Research-status Report
  • [Presentation] 早産児の脳内代謝物濃度とDKI解析値との関連性2017

    • Author(s)
      富安もよこ、相田典子、立花泰彦、柴崎淳、友滝清一、佐藤公彦、草切孝貴、村本安武、鈴木悠一、清水栄司、小畠隆行
    • Organizer
      第45回日本磁気共鳴医学会大会.宇都宮.2017.9.14.
    • Related Report
      2017 Research-status Report
  • [Presentation] n vivo GABA signal quantification in the neonatal brain using MR spectroscopy2017

    • Author(s)
      Moyoko Tomiyasu
    • Organizer
      第45回日本磁気共鳴医学会大会.宇都宮.2017.9.15.
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Relationship between brain metabolite concentrations/volumes during neonatal period and developmental prognosis in premature birth babies.2016

    • Author(s)
      Tomiyasu M, Aida N, Shibasaki J, Tomotaki S, Sato M, Kusagiri K, Muramoto Y, Suzuki Y, Kawasaki Y, Shimizu E, Obata T.
    • Organizer
      第44日本磁気共鳴医学会大会
    • Place of Presentation
      大宮ソニックシティ、さいたま市、埼玉県
    • Year and Date
      2016-09-09
    • Related Report
      2016 Research-status Report
  • [Presentation] Estimation of in vivo γ-aminobutyric acid (GABA) levels in the neonatal brain.2016

    • Author(s)
      Tomiyasu M, Aida N, Shibasaki J, Murata K, Heberlein K, Brown MA, Shimizu E, Tsuji H, Obata T.
    • Organizer
      ISMRM. 24th Annual meeting & exhibition.
    • Place of Presentation
      Suntec Singapore Convention & Exhibition Centre, Suntec city, Singapore
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Absolute metabolite concentration of Creatine in the deep gray matter measured using short echo 1H-MRS predict long-term prognosis of neonatal hypoxic-ischemic encephalopathy as excellent as NAA concentration.2016

    • Author(s)
      Aida N, Shibasaki J, Tomiyasu M, Nishi Y, Morisaki N, Fujiwara T, Toyoshima K, Obata T.
    • Organizer
      ISMRM. 24th Annual meeting & exhibition.
    • Place of Presentation
      Suntec Singapore Convention & Exhibition Centre, Suntec city, Singapore
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] The neuroimaging findings of Joubert syndrome with the C5ORF42 gene mutation do not show the classic molar tooth sign2015

    • Author(s)
      榎園美香子
    • Organizer
      第101回北米放射線学会
    • Place of Presentation
      シカゴ
    • Year and Date
      2015-11-29
    • Related Report
      2015 Research-status Report
  • [Presentation] In vivo 1H MRSによる新生児脳内GABAレベルの測定2015

    • Author(s)
      富安 もよこ
    • Organizer
      第43回日本磁気共鳴医学会大会
    • Place of Presentation
      東京
    • Year and Date
      2015-09-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 脳クレアチン欠乏症のMRI/MRS 所見の検討2015

    • Author(s)
      相田 典子
    • Organizer
      第43回日本磁気共鳴医学会大会
    • Place of Presentation
      東京
    • Year and Date
      2015-09-10
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi