Complex network structure in dementia: a graph theoretical analysis.

• Project/Area Number: 15K09944
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
• Principal Investigator: Shimoji Keigo 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (20348931)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: MRI / brain / diffusion tensor imaging / 脳MRI / 拡散MRI / 複雑ネットワーク / グラフ理論 / magnetic resonance / diffusion tensor

Outline of Final Research Achievements

Complex network analysis using graph theory was performed using both 3D-T1 weighted images and diffusion tensor images. In complex network analysis, we first set the region of interest in the whole brain and perform diffusion tensor tractography to weigh the strength of binding between regions of interest and analyze the strength of binding between regions of interest using graph theory. We considered the whole brain as one complex network and investigated whether there is a disease specific network characteristic. In parallel with the analysis of network characteristics, we also examined the brain microstructure by q-space imaging (QSI). In the study by QSI, the full width at half maximum (dFWH) was dominantly higher as the neutral fat was higher.

Research Products

• [Journal Article] Connectome analysis with diffusion MRI in idiopathic Parkinson's disease: Evaluation using multi-shell, multi-tissue, constrained spherical deconvolution. (2017)
  • Author(s): Kamagata K, Zalesky A, Hatano T, Di Biase MA, El Samad O, Saiki S, Shimoji K, Kumamaru KK, Kamiya K, Hori M, Hattori N, Aoki S, Pantelis C.
  • Journal Title: Neuroimage Clinical Volume: 17 Pages: 518-529
  • DOI: 10.1016/j.nicl.2017.11.007
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impaired prefrontal activity to regulate the intrinsic motivation-action link in schizophrenia. (2017)
  • Author(s): K. Takeda, M. Matsumoto, Y. Ogata, K. Maida, H. Murakami, K. Murayama, K. Shimoji, T. Hanakawa, K. Matsumoto, K. Nakagome.
  • Journal Title: NeuroImage: Clinical Volume: 16 Pages: 32-42
  • DOI: 10.1016/j.nicl.2017.07.003
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dinosaur Tail Sign: A useful Spinal MRI Findings Indicative of Cerebrospinal Fluid Leakage (2017)
  • Author(s): Sakurai K, Kanoto M, Nakagawa M, Shimohira M, Tokumaru AM, Kameyama M, Shimoji K, Morimoto S, Matsukawa N, Nishio M, Shibamoto Y.
  • Journal Title: Headache Volume: 印刷中 Issue: 6 Pages: 917-925
  • DOI: 10.1111/head.13075
  • Peer Reviewed
• [Journal Article] Predictors of Recovery from Traumatic Brain Injury-Induced Prolonged Consciousness Disorder. (2017)
  • Author(s): Abe, H., Shimoji, K., Nagamine, Y., Fujiwara, S. & Izumi, SI.
  • Journal Title: Neural Plasticity Volume: 2017 Pages: 9358092-9358092
  • DOI: 10.1155/2017/9358092
  • Peer Reviewed / Open Access
• [Journal Article] Longitudinal study examining abnormal white matter integrity using a tract-specific analysis in individuals with a high risk for psychosis. (2017)
  • Author(s): Saito, J., Hori, M., Nemoto, T., Katagiri, N., Shimoji, K., Ito, S., Tsujino, N., Yamaguchi, T., Shiraga, N., Aoki, S. & Mizuno, M.
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: Aug;71(8): Issue: 8 Pages: 530-541
  • DOI: 10.1111/pcn.12515
  • Peer Reviewed / Open Access
• [Journal Article] Adverse effects of metallic artifacts on voxel-wise analysis and tract-based spatial statistics in diffusion tensor imaging. (2017)
  • Author(s): Goto M, Abe O, Hata J, Fukunaga I, Shimoji K, Kunimatsu A, Gomi T.
  • Journal Title: Acta Radiol Volume: 58 Issue: 2 Pages: 211-217
  • DOI: 10.1177/0284185116641348
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Volume of Interest Analysis of Spatially Normalized PRESTO Imaging to Differentiate between Parkinson Disease and Atypical Parkinsonian Syndrome (2017)
  • Author(s): Sakurai K, Imabayashi E, Tokumaru AM, Ito K, Shimoji K, Nakagawa M, Ozawa Y, Shimohira M, Ogawa M, Morimoto S, Aiba I, Matsukawa N, Shibamoto Y.
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 16 Issue: 1 Pages: 16-22
  • DOI: 10.2463/mrms.mp.2015-0132
  • NAID: 130005286869
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Open Access
• [Journal Article] Neurite orientation dispersion and density imaging in the substantia nigra in idiopathic Parkinson disease. (2015)
  • Author(s): Kamagata K, Hatano T, Okuzumi A, Motoi Y, Abe O, Shimoji K, Kamiya K, Suzuki M, Hori M, Kumamaru KK, Hattori N, Aoki S.
  • Journal Title: Eur Radiol. Volume: Oct Issue: 8 Pages: 0-0
  • DOI: 10.1007/s00330-015-4066-8
  • Peer Reviewed / Open Access
• [Journal Article] A longitudinal study investigating sub-threshold symptoms and white matter changes in individuals with an 'at risk mental state' (ARMS). (2015)
  • Author(s): Katagiri N, Pantelis C, Nemoto T, Zalesky A, Hori M, Shimoji K, Saito J, Ito S, Dwyer DB, Fukunaga I, Morita K, Tsujino N, Yamaguchi T, Shiraga N, Aoki S, Mizuno M.
  • Journal Title: Schizophr Res. Volume: 162 Issue: 1-3 Pages: 7-13
  • DOI: 10.1016/j.schres.2015.01.002
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Intersite Reliability of Diffusion Tensor Imaging on Two 3T Scanners (2015)
  • Author(s): Koji Kamagata, Keigo Shimoji, Masaaki Hori, Akira Nishikori, Kohei Tsuruta, Mariko Yoshida, Kouhei Kamiya, Ryusuke Irie, Michimasa Suzuki, Shinsuke Kyogoku, Yuriko Suzuki, Noriko Sato, Shigeki Aoki.
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 14 Issue: 3 Pages: 227-233
  • DOI: 10.2463/mrms.2014-0077
  • NAID: 130005093234
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Open Access / Acknowledgement Compliant