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Complex network structure in dementia: a graph theoretical analysis.

Research Project

Project/Area Number 15K09944
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionTokyo Metropolitan Geriatric Hospital and Institute of Gerontology

Principal Investigator

Shimoji Keigo  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (20348931)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
KeywordsMRI / brain / diffusion tensor imaging / 脳MRI / 拡散MRI / 複雑ネットワーク / グラフ理論 / magnetic resonance / diffusion tensor
Outline of Final Research Achievements

Complex network analysis using graph theory was performed using both 3D-T1 weighted images and diffusion tensor images. In complex network analysis, we first set the region of interest in the whole brain and perform diffusion tensor tractography to weigh the strength of binding between regions of interest and analyze the strength of binding between regions of interest using graph theory. We considered the whole brain as one complex network and investigated whether there is a disease specific network characteristic. In parallel with the analysis of network characteristics, we also examined the brain microstructure by q-space imaging (QSI). In the study by QSI, the full width at half maximum (dFWH) was dominantly higher as the neutral fat was higher.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2017 2015

All Journal Article (10 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 10 results,  Open Access: 7 results,  Acknowledgement Compliant: 3 results)

  • [Journal Article] Connectome analysis with diffusion MRI in idiopathic Parkinson's disease: Evaluation using multi-shell, multi-tissue, constrained spherical deconvolution.2017

    • Author(s)
      Kamagata K, Zalesky A, Hatano T, Di Biase MA, El Samad O, Saiki S, Shimoji K, Kumamaru KK, Kamiya K, Hori M, Hattori N, Aoki S, Pantelis C.
    • Journal Title

      Neuroimage Clinical

      Volume: 17 Pages: 518-529

    • DOI

      10.1016/j.nicl.2017.11.007

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Impaired prefrontal activity to regulate the intrinsic motivation-action link in schizophrenia.2017

    • Author(s)
      K. Takeda, M. Matsumoto, Y. Ogata, K. Maida, H. Murakami, K. Murayama, K. Shimoji, T. Hanakawa, K. Matsumoto, K. Nakagome.
    • Journal Title

      NeuroImage: Clinical

      Volume: 16 Pages: 32-42

    • DOI

      10.1016/j.nicl.2017.07.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dinosaur Tail Sign: A useful Spinal MRI Findings Indicative of Cerebrospinal Fluid Leakage2017

    • Author(s)
      Sakurai K, Kanoto M, Nakagawa M, Shimohira M, Tokumaru AM, Kameyama M, Shimoji K, Morimoto S, Matsukawa N, Nishio M, Shibamoto Y.
    • Journal Title

      Headache

      Volume: 印刷中 Issue: 6 Pages: 917-925

    • DOI

      10.1111/head.13075

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predictors of Recovery from Traumatic Brain Injury-Induced Prolonged Consciousness Disorder.2017

    • Author(s)
      Abe, H., Shimoji, K., Nagamine, Y., Fujiwara, S. & Izumi, SI.
    • Journal Title

      Neural Plasticity

      Volume: 2017 Pages: 9358092-9358092

    • DOI

      10.1155/2017/9358092

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Longitudinal study examining abnormal white matter integrity using a tract-specific analysis in individuals with a high risk for psychosis.2017

    • Author(s)
      Saito, J., Hori, M., Nemoto, T., Katagiri, N., Shimoji, K., Ito, S., Tsujino, N., Yamaguchi, T., Shiraga, N., Aoki, S. & Mizuno, M.
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: Aug;71(8): Issue: 8 Pages: 530-541

    • DOI

      10.1111/pcn.12515

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adverse effects of metallic artifacts on voxel-wise analysis and tract-based spatial statistics in diffusion tensor imaging.2017

    • Author(s)
      Goto M, Abe O, Hata J, Fukunaga I, Shimoji K, Kunimatsu A, Gomi T.
    • Journal Title

      Acta Radiol

      Volume: 58 Issue: 2 Pages: 211-217

    • DOI

      10.1177/0284185116641348

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Volume of Interest Analysis of Spatially Normalized PRESTO Imaging to Differentiate between Parkinson Disease and Atypical Parkinsonian Syndrome2017

    • Author(s)
      Sakurai K, Imabayashi E, Tokumaru AM, Ito K, Shimoji K, Nakagawa M, Ozawa Y, Shimohira M, Ogawa M, Morimoto S, Aiba I, Matsukawa N, Shibamoto Y.
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 16 Issue: 1 Pages: 16-22

    • DOI

      10.2463/mrms.mp.2015-0132

    • NAID

      130005286869

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neurite orientation dispersion and density imaging in the substantia nigra in idiopathic Parkinson disease.2015

    • Author(s)
      Kamagata K, Hatano T, Okuzumi A, Motoi Y, Abe O, Shimoji K, Kamiya K, Suzuki M, Hori M, Kumamaru KK, Hattori N, Aoki S.
    • Journal Title

      Eur Radiol.

      Volume: Oct Issue: 8 Pages: 0-0

    • DOI

      10.1007/s00330-015-4066-8

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A longitudinal study investigating sub-threshold symptoms and white matter changes in individuals with an 'at risk mental state' (ARMS).2015

    • Author(s)
      Katagiri N, Pantelis C, Nemoto T, Zalesky A, Hori M, Shimoji K, Saito J, Ito S, Dwyer DB, Fukunaga I, Morita K, Tsujino N, Yamaguchi T, Shiraga N, Aoki S, Mizuno M.
    • Journal Title

      Schizophr Res.

      Volume: 162 Issue: 1-3 Pages: 7-13

    • DOI

      10.1016/j.schres.2015.01.002

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Intersite Reliability of Diffusion Tensor Imaging on Two 3T Scanners2015

    • Author(s)
      Koji Kamagata, Keigo Shimoji, Masaaki Hori, Akira Nishikori, Kohei Tsuruta, Mariko Yoshida, Kouhei Kamiya, Ryusuke Irie, Michimasa Suzuki, Shinsuke Kyogoku, Yuriko Suzuki, Noriko Sato, Shigeki Aoki.
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 14 Issue: 3 Pages: 227-233

    • DOI

      10.2463/mrms.2014-0077

    • NAID

      130005093234

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant

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Published: 2015-04-16   Modified: 2019-03-29  

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