| Project/Area Number |
15K09945
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Gunma University |
|---|
Principal Investigator |
HIGUCHI TETSUYA 群馬大学, 大学院医学系研究科, 准教授 (60323367)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
YAMAGUCHI AIKO 群馬大学, 大学院医学系研究科, 寄付講座教員 (80609032)
|
|---|
| Research Collaborator |
IIDA YASUHIKO 鈴鹿医療科学大学, 薬学部, 教授 (60252425)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 甲状腺分化癌 / I-131治療抵抗性 / Cu-64 DOTA-TATE / Y-90 DOTA-TATE / FDG-PET / サイログロブリン倍加時間 / Cu-64 / DOTA-TATE / 分化型甲状腺癌 / ソマトスタチン受容体 / ヨード治療抵抗性 / 甲状腺癌 / RI治療 / PET |
|---|
| Outline of Final Research Achievements |
Clinical usefulness of FDG-PET and thyroglobulin (Tg) measurement for the early diagnosis of Radioactive Iodine Refractory Differentiated Thyroid Carcinoma (RR-DTC), was evaluated in patients treated with I-131. SUVmax value and shortened Tg doubling time (Tg-DT) calculated from recent 4 Tg values less than 1 year were suggested to be a useful predictor of progressive disease (PD).
On the other hand, nude mice inoculated with follicular thyroid cancer cell line (FTC-133) were injected by Cu-64 DOTA-TATE and In-111 DOTA-TATE and clear tumor accumulation were proved, thus experimental Sstr-2 expressing animal model was established. Y-90 DOTA-TATE was used and treatment experiment was performed in 3 groups: control (n=5), 200 μCi (n=4) and 300 μCi (n=4). Dose dependent therapeutic effect was confirmed with the best response in 300 μCi group.
|
