Development of a new-generation medical imaging diagnosis system integrating artificial intelligence and risk models

• Project/Area Number: 15K09947
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kanazawa University
• Principal Investigator: Nakajima Kenichi 金沢大学, 医学系, 准教授 (00167545)
• Co-Investigator(Renkei-kenkyūsha): Okuda Koichi 金沢医科大学, 一般教育機構, 講師 (60639938) ; Matsuo Shinro 金沢大学附属病院, 講師 (30359773)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 人工ニューラルネットワーク / 虚血性心疾患 / 心不全 / 心筋血流イメージング / 心臓交感神経イメージング / リスクモデル / 心臓核医学 / 多施設研究 / 心筋交感神経イメージング / 画像診断 / 人工知能 / 標準化

Outline of Final Research Achievements

Clinical diagnosis of ischemic heart disease and heart failure is based on integrated assessment of clinical course, blood sampling, and imaging. The aim of this study was to create models by artificial intelligence or multivariable statistical analysis. Databases of patients with cardiac diseases were made by multicenter collaboration. With respect to myocardial perfusion imaging, using feature extractions and neural networks, diagnostic accuracy reached a level of expert interpretation. In patients with heart failure, multivariable risk model including 123I-metaiodobenzylguanidine successfully provided risk of cardiac death. Both algorithms were prepared as software for clinical uses.

Research Products

• [Int'l Joint Research] アムステルダム大学(オランダ)
• [Int'l Joint Research] アムステルダム大学(オランダ)
• [Int'l Joint Research] Amsterdam University(オランダ)
• [Journal Article] A European myocardial 123I-mIBG cross-calibration-phantom study. (2018)
  • Author(s): Verschure DO, Poel E, Nakajma K, Okuda K, Van Eck-Smit BLF, Somsen GA, Verberne HJ
  • Journal Title: J Nucl Cardiol Volume: Epub
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Validation of 2-year 123I-meta-iodobenzylguanidine-based cardiac mortality risk model in chronic heart failure (2018)
  • Author(s): Nakajima K, Nakata T, Doi T, Kadokami T, Matsuo S, Konno T, Yamada T, Jacobson AF
  • Journal Title: Eur Heart J Cardiovasc Imaging Volume: Epub Issue: 7 Pages: 749-756
  • DOI: 10.1093/ehjci/jey016
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cardiac sympathetic nervous system imaging with 123I-meta-iodobenzylguanidine: Perspectives from Japan and Europe (2017)
  • Author(s): Nakajima K, Scholte A, Nakata T, Dimitriu-Leen AC, Chikamori T, Vitola J, Yoshinaga K
  • Journal Title: J Nucl Cardiol Volume: 24 Issue: 3 Pages: 952-962
  • DOI: 10.1007/s12350-017-0818-y
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Standardization of 123I-meta-iodobenzylguanidine myocardial sympathetic activity imaging: phantom calibration and clinical applications (2017)
  • Author(s): Nakajima K, Verschure DO, Okuda K, Verberne HJ
  • Journal Title: Clin Transl Imaging Volume: 5 Issue: 3 Pages: 255-263
  • DOI: 10.1007/s40336-017-0230-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cross calibration of 123I-meta-iodobenzylguanidine heart-to-mediastinum ratio with D-SPECT planogram and Anger camera (2017)
  • Author(s): Nakajima K, Okuda K, Yokoyama K, Yoneyama T, Tsuji S, Oda H, Yoshita M, Kubota K
  • Journal Title: Ann Nucl Med Volume: 31 Issue: 8 Pages: 605-615
  • DOI: 10.1007/s12149-017-1191-2
  • Peer Reviewed / Open Access
• [Journal Article] Diagnostic accuracy of an artificial neural network compared with statistical quantitation of myocardial perfusion images: a Japanese multicenter study (2017)
  • Author(s): Nakajima Kenichi、Kudo Takashi、Nakata Tomoaki、Kiso Keisuke、Kasai Tokuo、Taniguchi Yasuyo、Matsuo Shinro、Momose Mitsuru、Nakagawa Masayasu、Sarai Masayoshi、Hida Satoshi、Tanaka Hirokazu、Yokoyama Kunihiko、Okuda Koichi、Edenbrandt Lars
  • Journal Title: European Journal of Nuclear Medicine and Molecular Imaging Volume: 44 Issue: 13 Pages: 2280-2289
  • DOI: 10.1007/s00259-017-3834-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comparison of phase dyssynchrony analysis using gated myocardial perfusion imaging with four software programs: Based on the Japanese Society of Nuclear Medicine working group normal database. (2017)
  • Author(s): Kenichi Nakajima, Koichi Okuda, Shinro Matsuo, Keisuke Kiso, Seigo Kinuya, Ernest V. Garcia
  • Journal Title: J Nucl Cardiol Volume: 印刷中 Issue: 2 Pages: 611-621
  • DOI: 10.1007/s12350-015-0333-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A European myocardial 123I-mIBG cross-calibration phantom study (2017)
  • Author(s): Verschure DO, Poel E, Nakajima K, Okuda K, van Eck Smit BLF,Somsen GA, Verberne HV
  • Journal Title: J Nucl Cardiol Volume: 24 Issue: 4 Pages: 1191-1197
  • DOI: 10.1007/s12350-017-0782-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Creation of mortality risk charts using 123I meta-iodobenzylguanidine heart-to-mediastinum ratio in patients with heart failure: 2- and 5-year risk models. (2016)
  • Author(s): enichi Nakajima, Tomoaki Nakata, Shinro Matsuo, Arnold F Jacobson.
  • Journal Title: European Heart Journal - Cardiovascular Imaging Volume: in press Issue: 10 Pages: 1138-1145
  • DOI: 10.1093/ehjci/jev322
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The time has come to standardize (123)I-MIBG heart-to-mediastinum ratios including planar and SPECT methods. (2016)
  • Author(s): Nakajima K, Okuda K, Matsuo S, Agostini D.
  • Journal Title: Eur J Nucl Med Mol Imaging. Volume: 43 Issue: 2 Pages: 386-388
  • DOI: 10.1007/s00259-015-3258-4
  • NAID: 120005890406
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Normal values and standardization of parameters in nuclear cardiology: Japanese Society of Nuclear Medicine working group database. (2016)
  • Author(s): Kenichi Nakajima, Naoya Matsumoto, Tokuo Kasai, Shinro Matsuo, Keisuke Kiso, Koichi Okuda.
  • Journal Title: Annals of Nuclear Medicine Volume: 30 Issue: 3 Pages: 188-199
  • DOI: 10.1007/s12149-016-1065-z
  • Peer Reviewed / Open Access
• [Journal Article] 123I-Meta-iodobenzylguanidine sympathetic imaging: standardization and application to neurological diseases (2016)
  • Author(s): Nakajima K, Yamada M
  • Journal Title: Chonnam Medical Journal Volume: 52 Issue: 3 Pages: 145-150
  • DOI: 10.4068/cmj.2016.52.3.145
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] ¹²³I-Meta-Iodobenzylguanidine Imaging (2016)
  • Author(s): Nakajima K
  • Journal Title: Annals of Nuclear Cardiology Volume: 2 Issue: 1 Pages: 152-156
  • DOI: 10.17996/ANC.02.01.152
  • NAID: 130007041099
  • ISSN: 2189-3926, 2424-1741
  • Peer Reviewed / Open Access
• [Journal Article] Cardiac 123I-MIBG imaging for clinical decision making: 22-year experience in Japan (2015)
  • Author(s): Nakajima K, Nakata T
  • Journal Title: J Nucl Med Volume: 56 Issue: Supplement 4 Pages: 11S-19S
  • DOI: 10.2967/jnumed.114.142794
  • NAID: 120005672827
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Creation and validation of artificial intelligence for stress myocardial perfusion imaging: A Japanese multicenter project (2017)
  • Author(s): Nakajima K, Kiso K, Kudo T, Kasai T, Taniguchi Y, Matsuo S, Nakagawa M, Nakata T, Hida S, Tanaka H, Sarai M, Yokoyama K, Kondo C, Okuda K, Edenbrandt L
  • Organizer: Annual Meeting of European Association of Nuclear Medicine, Vienna, Austria
  • Int'l Joint Research
• [Presentation] Prediction of heart failure death based on 2-year cardiac mortality risk model: reclassification analysis compared with conventional variables (2017)
  • Author(s): Nakajima K, Nakata T, Doi T, Kadokami, Matsuo S, Konno T, yamada T, Jacobson A
  • Organizer: Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, Denver, USA
  • Int'l Joint Research
• [Presentation] Is cardiac death predictable by I-123 metaiodobenzylguanidine risk model in chronic heart failure? (2017)
  • Author(s): Nakajima K, Nakata T, Doi T, Kadokami, Matsuo S, Konno T, Yamada T, Jacobson A
  • Organizer: International Conference of Nuclear Cardiology and Cardiac CT, Vienna, Austria
  • Int'l Joint Research
• [Presentation] Validation of the 2-year cardiac morality risk model using I-123 meta-iodobenzylguanidine in chronic heart failure (2016)
  • Author(s): Nakajima K, Nakata T, Doi T, Kadokami T, Matsuo S, Konno T, Yamada T, Jacobson A
  • Organizer: European Association of Nuclear Medicine Annual Meeting
  • Place of Presentation: Barcelona
  • Year and Date: 2016-10-15
  • Int'l Joint Research
• [Presentation] I-123 MIBG adrenergic imaging with a CZT camera: To integrate Anger and CZT approaches (2016)
  • Author(s): Nakajima K
  • Organizer: European Association of Nuclear Medicine Annual Meeting
  • Place of Presentation: Barcelona
  • Year and Date: 2016-10-15
  • Int'l Joint Research / Invited
• [Presentation] Cardiac mortality risk chart in chronic heart failure: multivariate I-123 meta-iodobenzylguanidine risk model incorporating correction of collimator differences (2016)
  • Author(s): Nakajima K, Nakata T, Matsuo S, Jacobson AF, Okuda K, Kinuya S
  • Organizer: Society of Nuclear Medicine and Molecular Imaging
  • Place of Presentation: San Diego
  • Year and Date: 2016-06-12
  • Int'l Joint Research
• [Presentation] Phase dyssynchrony parameters in gated myocardial perfusion imaging: Normal ranges and affecting factors in four software programs (2016)
  • Author(s): Nakajima K, Okuda K, Matsuo S, Kiso K, Kinuya S, Garcia EV
  • Organizer: Society of Nuclear Medicine and Molecular Imaging
  • Place of Presentation: San Diego
  • Year and Date: 2016-06-12
  • Int'l Joint Research
• [Presentation] Prediction of cardiac mortality using I-123 MIBG in chronic heart failure: Creation of 2-year and 5-year mortality risk charts (2016)
  • Author(s): Nakajima K, Nakata T, Matsuo S, Yamada T, Kasma S, Momose M
  • Organizer: Annual Meeting of Japanese Circulation Society
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-20
• [Presentation] Cardiac MIBG imaging in chronic heart failure : 23-year experience in Japan (2016)
  • Author(s): Nakajima K
  • Organizer: Taiwan Society of Nuclear Cardiology
  • Place of Presentation: Taipei (Taiwan)
  • Year and Date: 2016-03-11
  • Int'l Joint Research / Invited
• [Presentation] Clinical application of I-123 MIBG imaging in Lewy-body diseases and related movement disorders (2016)
  • Author(s): Nakajima K
  • Organizer: Taiwan Society of Nuclear Cardiology
  • Place of Presentation: Taipei (Taiwan)
  • Year and Date: 2016-03-11
  • Int'l Joint Research / Invited
• [Presentation] I-123 MIBG: from standardization to risk estimation. In: ASNC-JSNC joint session - "Recent development and future directions of sympathetic nervous function imaging" (2016)
  • Author(s): Kenichi Nakajima
  • Organizer: The 26th Annual Meeting of Japanese Society of Nuclear Cardiology
  • Place of Presentation: 津
• [Presentation] Standardization of Nuclear Imaging and Data Analysis（心臓核医学画像と解析の標準化）[教育講演] (2015)
  • Author(s): Nakajima K (中嶋憲一)
  • Organizer: 日本核医学会総会
  • Place of Presentation: 東京
  • Year and Date: 2015-11-06
  • Invited
• [Presentation] Effect of standardization of I-123 MIBG heart-to-mediastinum ratio on the prognostic threshold: application to multicenter database of chronic heart failure (2015)
  • Author(s): Nakajima K, Okuda K, Matsuo S, Nakata T, Kinuya S
  • Organizer: Annual Meeting of European Association of Nuclear Medicine and Molecular Imaging
  • Place of Presentation: Hamburg (Germany)
  • Year and Date: 2015-10-10
  • Int'l Joint Research
• [Presentation] Detection of myocardial ischemia using artificial neural network: different characteristics from conventional defect scoring methods (2015)
  • Author(s): Nakajima K, Matsuo S, Okuda K, Yokoyama K, Bunko H, Kinuya S, Edenbrandt L
  • Organizer: Annual Meeting of European Association of Nuclear Medicine and Molecular Imaging
  • Place of Presentation: Hamburg (Germany)
  • Year and Date: 2015-10-10
  • Int'l Joint Research
• [Presentation] Multicenter normal Tl-201 databases with multifocal collimators for supine, prone and CT-based corrections (2015)
  • Author(s): Nakajima K, Okuda K, Matsuo S, Kondo C, Sarai M, Horiguchi Y, Onoguchi M, Kinuya S
  • Organizer: Society of Nuclear Medicine and Molecular Imaging 2015 Annual Meeting
  • Place of Presentation: Baltimore (USA)
  • Year and Date: 2015-06-09
  • Int'l Joint Research
• [Presentation] Standardization of quantitative I-123 metaiodobenzylguanidine imaging algorithm for the assessment from diagnosis to prognosis in patients with heart failure (2015)
  • Author(s): Nakajima K, Matsuo S, Nakata T, Okuda K, Kinuya S
  • Organizer: Society of Nuclear Medicine and Molecular Imaging 2015 Annual Meeting
  • Place of Presentation: Baltimore (USA)
  • Year and Date: 2015-06-09
  • Int'l Joint Research
• [Presentation] I-123 meta-iodobenzylguanidine imaging is effective for both long-term and short-term prognostic evaluation (2015)
  • Author(s): Nakajima K, Nakata T, Matsuo S, Jacobson A
  • Organizer: The 12nd International Conference of Nuclear Cardiology and Cardiac CT
  • Place of Presentation: Madrid (Spain)
  • Year and Date: 2015-05-04
  • Int'l Joint Research