Development of radiolabeled compound for diagnosis and therapy of primary tumor and bone metastases
| Project/Area Number |
15K09948
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kanazawa University |
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Principal Investigator |
Ogawa Kazuma 金沢大学, 新学術創成研究機構, 准教授 (30347471)
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| Co-Investigator(Renkei-kenkyūsha) |
WASHIYAMA Kohshin 福島県立医科大学, ふくしま国際医療科学センター, 准教授 (80313675)
NAKAYAMA Morio 長崎大学, 薬学部, 教授 (60164373)
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| Research Collaborator |
Ishizaki Atusshi
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 骨転移 / 診断 / 治療 / 放射性核種 / セラノスティクス / イメージング / RI内用療法 / プローブ / PET / 癌 / ペプチド |
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| Outline of Final Research Achievements |
A probe containing an aspartic acid peptide linker (D11) as a carrier to bone metastases, an RGD peptide [c(RGDfK) peptide] as a carrier to the primary cancer, and Ga-DOTA as a stable radiometal complex for imaging in one molecule, 67Ga-DOTA-D11-c(RGDfK), was prepared and evaluated to detect both the primary cancer and bone metastases simultaneously. Biodistribution experiments and single photon emission tomography (SPECT) imaging using tumor-bearing mice were performed. 67Ga-DOTA-D11-c(RGDfK) exhibited high uptake in bone and tumor. The accumulation of 67Ga-DOTA-D11-c(RGDfK) in tumor decreased when it was co-injected with c(RGDfK) peptide. Since 90Y-DOTA-D11-c(RGDfK) showed similar characteristics, they have great potential as theranostics system for diagnosis and therapy of both the primary cancer and bone metastases simultaneously.
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Report
(4 results)
Research Products
(6 results)
