| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
In epilepsy model rat brain, 13N-ammonia uptakes in adult and young rat brain showed remarkable increase. In young epilepsy model rat brain, the astrocytic TCA cycle was not enhanced, but their glutamate-gluamine cycle was remarkably activated. The chemical kindling was not developed in young animals under the same condition as adult animals. The relationship between the epileptogenicity and the functional alteration in GABA-BZ complex during young period is suggested.
And we also developed a simple ex-vivo semi-quantitative fluorescent imaging technique. This technique is applicable for multi-tracer imaging with both fluorescent-labeled and radiolabeled probes in the same animal and would allow more detailed analysis of the diseased states of the animals even with wide individual variations.
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