Hyperthermia at the single-cell level for purging disseminated disease with immuno-magnetic nanoparticles

• Project/Area Number: 15K09959
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Okayama University
• Principal Investigator: KISHIMOTO HIROYUKI 岡山大学, 大学病院, 講師 (50613155)
• Co-Investigator(Renkei-kenkyūsha): MICHIHIRO Aono 愛媛大学, 理工学研究科, 教授 (00184052)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 温熱療法 / 磁性ナノ粒子 / 腹膜播種 / 温熱治療

Outline of Final Research Achievements

Hyperthermia using magnetic nanoparticles and alternating magnetic field has been investigated in the past two decades and is promising for cancer therapy. However, in most cases, magnetic nanoparticles are simply administered by direct injection into the tumor, and the modality just treats only a few space-occupying lesions so far. We hypothesized that if the MNPs were delivered cancer specifically at the cellular level, Hyperthermia using magnetic nanoparticles would have the potential to treat various sorts of disseminated cancer diseases. The aim of this study was to seek for the cancer specific delivery system of immuno- magnetic nanoparticles and to establish the cancer selective intracellular hyperthermia.

Research Products

• [Presentation] Hyperthermia at the single-cell level for disseminated cancer disease with immuno-magnetic nanoparticles (2017)
  • Author(s): Tetsuya Kagawa, Hiroyuki Kishimoto, Toshiaki Ohara, Hiroshi Tazawa, Shunsuke Kagawa, Takeshi Nagasaka, Satoshi Nohara, Ichiro Kato, Adarsh Sandhu, Hiromichi Aono, Toshiyoshi Fujiwara
  • Organizer: AACR 2017
  • Int'l Joint Research
• [Presentation] 抗体結合磁性ナノ粒子による温熱療法－癌播種病変への治療応用へ向けて－ (2017)
  • Author(s): 香川哲也、岸本浩行、松三雄騎、田澤大、大原利章、永坂岳司、香川俊輔、藤原俊義
  • Organizer: 第76回日本癌学会学術集会
• [Presentation] 抗体結合磁性ナノ粒子による腫瘍選択的な細胞内温熱療法の開発 (2016)
  • Author(s): 香川哲也、岸本浩行、田澤 大、大原利章、永坂岳司、香川俊輔、藤原俊義
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-06