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Hyperthermia at the single-cell level for purging disseminated disease with immuno-magnetic nanoparticles

Research Project

Project/Area Number 15K09959
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionOkayama University

Principal Investigator

KISHIMOTO HIROYUKI  岡山大学, 大学病院, 講師 (50613155)

Co-Investigator(Renkei-kenkyūsha) MICHIHIRO Aono  愛媛大学, 理工学研究科, 教授 (00184052)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords温熱療法 / 磁性ナノ粒子 / 腹膜播種 / 温熱治療
Outline of Final Research Achievements

Hyperthermia using magnetic nanoparticles and alternating magnetic field has been investigated in the past two decades and is promising for cancer therapy. However, in most cases, magnetic nanoparticles are simply administered by direct injection into the tumor, and the modality just treats only a few space-occupying lesions so far. We hypothesized that if the MNPs were delivered cancer specifically at the cellular level, Hyperthermia using magnetic nanoparticles would have the potential to treat various sorts of disseminated cancer diseases. The aim of this study was to seek for the cancer specific delivery system of immuno- magnetic nanoparticles and to establish the cancer selective intracellular hyperthermia.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (3 results)

All 2017 2016

All Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Hyperthermia at the single-cell level for disseminated cancer disease with immuno-magnetic nanoparticles2017

    • Author(s)
      Tetsuya Kagawa, Hiroyuki Kishimoto, Toshiaki Ohara, Hiroshi Tazawa, Shunsuke Kagawa, Takeshi Nagasaka, Satoshi Nohara, Ichiro Kato, Adarsh Sandhu, Hiromichi Aono, Toshiyoshi Fujiwara
    • Organizer
      AACR 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 抗体結合磁性ナノ粒子による温熱療法-癌播種病変への治療応用へ向けて-2017

    • Author(s)
      香川哲也、岸本浩行、松三雄騎、田澤大、大原利章、永坂岳司、香川俊輔、藤原俊義
    • Organizer
      第76回日本癌学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 抗体結合磁性ナノ粒子による腫瘍選択的な細胞内温熱療法の開発2016

    • Author(s)
      香川哲也、岸本浩行、田澤 大、大原利章、永坂岳司、香川俊輔、藤原俊義
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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