Development of multipolar ablation with a three-dimensional simulator system for patients with liver cancer
Project/Area Number |
15K09960
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | Ehime University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 肝細胞癌 / シミュレーター / ラジオ波焼灼術 / ナビゲーター / 3次元画像 / シミュレーション / ナビゲーション / 肝がん / 超音波 |
Outline of Final Research Achievements |
We developed three-dimensional (3-D) sim-Navigator as anavigation and simulation system. And, we examined the efficacy of the 3-D sim-Navigator by analyzing relapse-free survival and deformity of the ablation volume in a clinical study. Mean sphericity was 0.48 ± 0.07 with 3-D sim-Navigator and 0.37 ± 0.07 without 3-D sim-Navigator (P < 0.001). Median surface-to-volume ratio and compactness were also significantly closer to those of a sphere with 3-D sim-Navigator (P = 0.017, P < 0.001). Relapse-free survival rates at 1 and 1.5 years were 94.1% and 82.4%, respectively, with 3-D sim-Navigator, compared with 83.2% and 55.5% without (P = 0.056). The only independent factor predicting relapse-free survival was use of 3-D sim-Navigator. Ideal ablation area was acquired by this simulation and navigation system inclinics. This system improved local tumor progression by facilitating appropriate insertionof multiple electrodes.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Nonalcoholic fatty liver with a hepatic arterial buffer response strongly associated with future metabolic disease.2017
Author(s)
Hirooka M, Koizumi Y, Miyake T, Watanabe T, Yoshida O, Tokumoto Y, Yukimoto A, Nakamura Y, Imai Y, Abe M, Hiasa Y.
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Journal Title
Hepatol Commun.
Volume: 1
Issue: 7
Pages: 623-633
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Characterization of the biliary tract by virtual ultrasonography constructed by gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging2015
Author(s)
Koizumi Y, Hirooka M, Ochi H, Tokumoto Y, Takechi M, Hiraoka A, Ikeda Y, Kumagi T, Matsuura B, Abe M, Hiasa Y.
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Journal Title
Journal of Medical Ultrasonics
Volume: 42
Issue: 2
Pages: 185-193
DOI
NAID
Related Report
Peer Reviewed / Open Access
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