| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Outline of Final Research Achievements |
In this research, irradiation damages to mice gut mucous membrane were analyzed with H-E staining and scanning electron microscopy. In both analysis, peelings of gut epithelium were observed and the frequency of damaged areas increased with the amount of gamma-irradiation. Orosomucoid is an acute-phase protein and reported to induce anti-inflammatory immune cells, such as type II monocytes through the production of interleukin(IL)-10. We administered recombinant orosomucoid to irradiated mice and compared gut mucosal damages with non-irradiated controls. Mucosal damges decreased in orosomucoid administered mice. These results suggested anti-inflammatory proteins may improve intestinal irradiation damages by inducing anti-inflammatory immune cells and IL-10 production.
|
