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Fundamental study on percutaneous thoracic duct embolization for chylothorax: Establishment of animal model and evaluation of safety

Research Project

Project/Area Number 15K09971
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionKeio University

Principal Investigator

INOUE Masanori  慶應義塾大学, 医学部(信濃町), 助教 (30338157)

Co-Investigator(Kenkyū-buntansha) 小野澤 志郎  帝京大学, 医学部, 講師 (10544398)
中塚 誠之  慶應義塾大学, 医学部(信濃町), 講師 (50188984)
陣崎 雅弘  慶應義塾大学, 医学部(信濃町), 教授 (80216259)
米虫 敦  関西医科大学, 医学部, 講師 (80360254)
屋代 英樹  慶應義塾大学, 医学部, 共同研究員 (90327643)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords乳び胸水 / 胸管 / 塞栓術 / リンパ管造影 / 胸管塞栓 / NBCA
Outline of Final Research Achievements

We have established animal model of chylothorax associated with thoracic duct injury. Using this model, we embolized thoracic duct using metallic coils or NBCA. Five days after thoracic duct embolization, we performed lymphangiography again and confirmed that thoracic duct is completely embolized in both embolic materials. A part of jejunum and ileum was removed and a pathological specimen was prepared. Pathological examination confirmed the safely of thoracic duct embolization.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Lymphatic Intervention for Various Types of Lymphorrhea: Access and Treatment2016

    • Author(s)
      Inoue M, et al
    • Journal Title

      Radiographics

      Volume: 36 Issue: 7 Pages: 2199-2211

    • DOI

      10.1148/rg.2016160053

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] Lymphatic intervention for various kinds of lymphorrhea: How to access and treat2015

    • Author(s)
      M Inoue, H Yashiro, S Nakatsuka, M Jinzaki
    • Organizer
      RSNA(Radiological Society of North America) 2015
    • Place of Presentation
      Chicago, U.S.A
    • Year and Date
      2015-11-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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