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Investigation of the molecular mechanism of transiently elevated tumor uptake of PET tracers at early time points after X-ray radiation

Research Project

Project/Area Number 15K09976
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionNational Institutes for Quantum and Radiological Science and Technology

Principal Investigator

TSUJI Atsushi  国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 分子イメージング診断治療研究部, チームリーダー(定常) (60303559)

Co-Investigator(Kenkyū-buntansha) 田畑 祥  慶應義塾大学, 政策・メディア研究科(藤沢), 特任助教 (30708342)
加藤 孝一  国立研究開発法人国立精神・神経医療研究センター, 脳病態統合イメージングセンター, 室長 (50382198)
Research Collaborator SUDO Hitomi  国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所分子イメージング診断治療研究部, 研究員 (10415416)
SUGYO Aya  国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所分子イメージング診断治療研究部, 技術員 (00415415)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsPET / 放射線 / アミノ酸 / アミノ酸トランスポーター / がん / メタボローム解析
Outline of Final Research Achievements

Contribution of amino acid transporters for PET tracer uptake was markedly different among tumor cells, suggesting the possibility of a new uptake mechanism. Our findings in evaluation for tumor uptake after radiation, there was a need to develop a new PET tracer. Therefore, we developed and evaluated cysteine-based tracers in vitro and in vivo. To explorer pathways associated with the mechanism of transiently elevated uptake, metabolome analysis was conducted. Tumors treated with AIB and X-rays showed increased metabolites on the glycolysis. Our findings warrant further studies to investigate the mechanism of transiently elevated uptake after X-ray radiation.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (15 results)

All 2018 2017 2016 2015 Other

All Journal Article (14 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 14 results,  Open Access: 6 results,  Acknowledgement Compliant: 5 results) Remarks (1 results)

  • [Journal Article] Antitumor effects of radionuclide treatment using α-emitting meta-211At-astato-benzylguanidine in a PC12 pheochromocytoma model2018

    • Author(s)
      Ohshima Yasuhiro、Sudo Hitomi、Watanabe Shigeki、Nagatsu Kotaro、Tsuji Atsushi B.、Sakashita Tetsuya、Ito Yoichi M.、Yoshinaga Keiichiro、Higashi Tatsuya、Ishioka Noriko S.
    • Journal Title

      European Journal of Nuclear Medicine and Molecular Imaging

      Volume: 45 Issue: 6 Pages: 999-1010

    • DOI

      10.1007/s00259-017-3919-6

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combined treatment of pancreatic cancer xenograft with 90Y-ITGA6B4-mediated radioimmunotherapy and PI3K/mTOR inhibitor2017

    • Author(s)
      3.Aung W, Tsuji AB, Sudo H, Sugyo A, Ukai Y, Kouda K, Kurosawa Y, Furukawa T, Saga T, Higashi T
    • Journal Title

      World J Gastroenterol

      Volume: 23 Pages: 7551-62

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular imaging using an anti-human tissue factor monoclonal antibody in an orthotopic glioma xenograft model2017

    • Author(s)
      5.Takashima H, Tsuji AB, Saga T, Yasunaga M, Koga Y, Kuroda JI, Yano S, Kuratsu JI, Matsumura Y
    • Journal Title

      Sci Rep

      Volume: 7 Pages: 12341-12341

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ynthesis and evaluation of 11C-labeled coumarin analog as an imaging probe for detecting monocarboxylate transporters expression2017

    • Author(s)
      6.Tateishi H, Tsuji AB, Kato K, Sudo H, Sugyo A, Hanakawa T, Zhang MR, Saga T, Arano Y, Higashi T
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 27 Pages: 4893-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of antibody-drug conjugates using DDS and molecular imaging2017

    • Author(s)
      7.Yasunaga M, Manabe S, Tsuji A, Furuta M, Ogata K, Koga Y, Saga T, Matsumura Y
    • Journal Title

      Bioengineering

      Volume: 4

    • NAID

      120006497386

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] αVβ3 Integrin-Targeted Radionuclide Therapy with 64Cu-cyclam-RAFT-c(-RGDfK-)4.2016

    • Author(s)
      Jin ZH, Furukawa T, Degardin M, Sugyo A, Tsuji AB, Yamasaki T, Kawamura K, Fujibayashi Y, Zhang MR, Boturyn D, Dumy P, Saga T.
    • Journal Title

      Mol Cancer Ther

      Volume: 15 Issue: 9 Pages: 2076-85

    • DOI

      10.1158/1535-7163.mct-16-0040

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Functional evaluation of rat hearts transplanted after preservation in a high-pressure gaseous mixture of carbon monoxide and oxygen.2016

    • Author(s)
      Hatayama N, Inubushi M, Naito M, Hirai S, Jin YN, Tsuji AB, Seki K, Itoh M, Saga T, Li XK..
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 32120-32120

    • DOI

      10.1038/srep32120

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Radioimmunotherapy of pancreatic cancer xenografts in nude mice using 90Y-labeled anti-α6β4 integrin antibody2016

    • Author(s)
      Aung W, Tsuji AB, Sudo H, Sugyo A, Ukai Y, Kouda K, Kurosawa Y, Furukawa T, Saga T
    • Journal Title

      Oncotarget

      Volume: 7 Issue: 25 Pages: 38835-38844

    • DOI

      10.18632/oncotarget.9631

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] In Vivo Simultaneous Imaging of Vascular Pool and Hypoxia with a HT-29 Tumor Model: the Application of Dual-Isotope SPECT/PET/CT.2016

    • Author(s)
      Adachi N, Yoshii Y, Furukawa T, Yoshimoto M, Takeuchi Y, Inubushi M, Wakizaka H, Zhang MR, Tsuji AB, Takahashi M, Fujibayashi Y, Saga T.
    • Journal Title

      International Journal of Sciences

      Volume: 25 Pages: 26-39

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Immunotargeting of integrin α6β4 for single-photon emission computed tomography and near-infrared fluorescence imaging in a pancreatic cancer model2016

    • Author(s)
      2.Winn Aung, Atsushi B.Tsuji, Hitomi Sudo, Aya Sugyo, Takako Furukawa, Yoshinori Ukai, Yoshikazu kurozawa, Tsuneo Saga
    • Journal Title

      Molecular Imaging

      Volume: 15

    • DOI

      10.1177/1536012115624917

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Establishment and evaluation of a new highly metastatic tumor cell line 5a-D-Luc-ZsGreen expressing both luciferase and green fluorescent protein2016

    • Author(s)
      Sudo H, Tsuji A B, Sugyo A, Takuwa H, Masamoto K, Tomita Y, Suzuki N, Imamura T, Koizumi M, Saga T
    • Journal Title

      Int. J. Oncol.

      Volume: 48 Issue: 2 Pages: 525-532

    • DOI

      10.3892/ijo.2015.3300

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] In-vivo imaging of blood-brain barrier permeability using positron emission tomography with 2-amino-[3-11C]isobutyric acid.2015

    • Author(s)
      Okada M, Kikuchi T, Okamura T, Ikoma Y, Tsuji AB, Wakizaka H, Kamakura T, Aoki I, Zhang MR, Kato K.
    • Journal Title

      Nucl Med Commun

      Volume: 36 Issue: 12 Pages: 239-48

    • DOI

      10.1097/mnm.0000000000000385

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Preclinical evaluation of 2-amino-2-[11C]methyl-butanoic acid as a potential tumor-imaging agent in a mouse model.2015

    • Author(s)
      Suzuki C, Tsuji AB, Kato K, Sudo H, Zhang MR, Saga T.
    • Journal Title

      Nucl Med Commun

      Volume: 36 Issue: 11 Pages: 1107-1112

    • DOI

      10.1097/mnm.0000000000000364

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Preclinical assessment of early tumor response after irradiation by positron emission tomography with 2-amino-[3-11C]isobutyric acid2015

    • Author(s)
      Tsuji AB, Sugyo A, Sudo H, Suzuki C, Wakizaka H, Zhang MR, Kato K, Saga T
    • Journal Title

      Oncol Rep

      Volume: 33 Issue: 5 Pages: 2361-7

    • DOI

      10.3892/or.2015.3868

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Remarks] 分子イメージング診断治療研究部

    • URL

      http://www.nirs.go.jp/rd/mit/index.html

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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