| Project/Area Number |
15K09976
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | National Institutes for Quantum and Radiological Science and Technology |
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Principal Investigator |
TSUJI Atsushi 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 分子イメージング診断治療研究部, チームリーダー(定常) (60303559)
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| Co-Investigator(Kenkyū-buntansha) |
田畑 祥 慶應義塾大学, 政策・メディア研究科(藤沢), 特任助教 (30708342)
加藤 孝一 国立研究開発法人国立精神・神経医療研究センター, 脳病態統合イメージングセンター, 室長 (50382198)
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| Research Collaborator |
SUDO Hitomi 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所分子イメージング診断治療研究部, 研究員 (10415416)
SUGYO Aya 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所分子イメージング診断治療研究部, 技術員 (00415415)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | PET / 放射線 / アミノ酸 / アミノ酸トランスポーター / がん / メタボローム解析 |
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| Outline of Final Research Achievements |
Contribution of amino acid transporters for PET tracer uptake was markedly different among tumor cells, suggesting the possibility of a new uptake mechanism. Our findings in evaluation for tumor uptake after radiation, there was a need to develop a new PET tracer. Therefore, we developed and evaluated cysteine-based tracers in vitro and in vivo. To explorer pathways associated with the mechanism of transiently elevated uptake, metabolome analysis was conducted. Tumors treated with AIB and X-rays showed increased metabolites on the glycolysis. Our findings warrant further studies to investigate the mechanism of transiently elevated uptake after X-ray radiation.
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