| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
18F-FEBMP, a novel PET ligand for neuroinflammation originally developed in QST, has more sensitively captured TSPO expression in brains from tauopathy mouse and quinolone-induced neuroinflammation marmoset models, compared with two typical TSPO ligands, 11C-PK11195 and 11C-Ac5216. This newly developed ligand has high brain uptake and affinity for TSPO. However, PET scans with it failed to detected TSPO expression in normal macaque monkey brain likely due to slow washout rate. So, we have concluded that 18F-FEBMP is very useful for neuroinflammation imaging in preclinical studies. However, it is required for application in human subjects to optimized chemical structure for rapid washout from brain.
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