Development of next-generation PET ligand for neuroinflammation and comparison with current ligands
| Project/Area Number |
15K09979
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | National Institutes for Quantum and Radiological Science and Technology |
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Principal Investigator |
JI BIN 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 脳機能イメージング研究部, 主任研究員(任常) (80392223)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | PET / 神経炎症 / Translocator Protein / TSPO / アルツハイマー病 |
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| Outline of Final Research Achievements |
18F-FEBMP, a novel PET ligand for neuroinflammation originally developed in QST, has more sensitively captured TSPO expression in brains from tauopathy mouse and quinolone-induced neuroinflammation marmoset models, compared with two typical TSPO ligands, 11C-PK11195 and 11C-Ac5216. This newly developed ligand has high brain uptake and affinity for TSPO. However, PET scans with it failed to detected TSPO expression in normal macaque monkey brain likely due to slow washout rate. So, we have concluded that 18F-FEBMP is very useful for neuroinflammation imaging in preclinical studies. However, it is required for application in human subjects to optimized chemical structure for rapid washout from brain.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Distinct binding of two PET ligands, PBB3 and AV-1451, to tau fibril strains in Alzheimer’s disease and related neurodegenerative tauopathy disorders.2017
Author(s)
71.Ono M, Sahara N, Kumata K, Ji B, Ni R, Dickson DW, Trojanowski JQ, Lee VM-Y, Yoshida M, Hozumi I, Yoshiyama Y, Nordberg A, Suhara T, Zhang M-R, Higuchi M.
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Journal Title
Brain
Volume: 140
Pages: 764-780
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Distinct binding of amyloid imaging ligands to unique amyloid-β deposited in the presubiculum of Alzheimer's disease2015
Author(s)
Ji B, Chen CJ, Bando K, Ashino H, Shiraishi H, Sano H, Kasahara H, Minamizawa T, Yamada K, Ono M, Zhang MR, Seki C, Farde L, Suhara T, Higuchi M
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Journal Title
J Neurochem
Volume: 135
Issue: 5
Pages: 859-66
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] [18F]FEBMP: Positron Emission Tomography Imaging of TSPO in a Model of Neuroinflammation in Rats, and in vitro Autoradiograms of the Human Brain2015
Author(s)
Tiwari AK, Ji B, Yui J, Fujinaga M, Yamasaki T, Xie L, Luo R, Shimoda Y, Kumata K, Zhang Y, Hatori A, Maeda J, Higuchi M, Wang F, Zhang MR.
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Journal Title
Theranostics
Volume: 26
Issue: 9
Pages: 961-9
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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