Evaluation of pancreatic regeneration and islet number in pancreas and islet transplantation using Positron emission tomography
| Project/Area Number |
15K09980
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | National Hospital Organization Chiba-East-Hospital |
|---|
Principal Investigator |
OTSUKI KAZUNORI 独立行政法人国立病院機構(千葉東病院臨床研究部), その他部局等, 研究員 (50399755)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
圷 尚武 独立行政法人国立病院機構(千葉東病院臨床研究部), その他部局等, 部長 (00344979)
丸山 通広 独立行政法人国立病院機構(千葉東病院臨床研究部), その他部局等, その他 (40399754)
西郷 健一 独立行政法人国立病院機構(千葉東病院臨床研究部), その他部局等, 研究員 (60323424)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
YOSHIKAWA kyosan 放射線医学総合研究所, 重粒子医科学センター, 画像診断室長 (00204793)
SAGA tuneo 放射線医学総合研究所, 分子イメージングセンター, プログラムリーダー (40273445)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 11C-methionine PET / CT volumetry / 膵再生 / 生体膵ドナー / C-methionine PET / 膵臓移植 / 核医学 / PET / 11C-methionine / 1型糖尿病 / 膵島移植 / 生着率 / インスリン / ＰＥＴ |
|---|
| Outline of Final Research Achievements |
To evaluate pancreas volumetric function (PVF) of the graft and live donor residual pancreas using 11C-methionine PET/CT in pancreas transplantation. Pre- and post-operative pancreas volume in donor was 29.3±7.5 and 38.0±7.9ml. Pre- and post-operative SUV in donor was 16.0±1.1and 16.9±5.0. PVF was elevated 1.38-times postoperatively. Assuming that the normal PVF is 100%, pre- and post-operative PVF in donor was 113% and 57%. Insulin independent PVF with brain-death and live donor was 70% and 24%. Insulin dependent PVF and graft failure was 12% and 0%.Pancreas regeneration was observed volumetric 38%, but functional 6% in donor pancreas.
|
Report
(4 results)
Research Products
(6 results)
