Study on the establishment of myelin-specific PET imaging technology

• Project/Area Number: 15K09981
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: Matsuda Hiroshi 国立研究開発法人国立精神・神経医療研究センター, 脳病態統合イメージングセンター, センター長 (90173848)
• Co-Investigator(Kenkyū-buntansha): 宿里 充穗 昭和薬科大学, 薬学部, 助教 (20525571) ; 加藤 孝一 国立研究開発法人国立精神・神経医療研究センター, 脳病態統合イメージングセンター, 室長 (50382198)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: PET / ミエリン / ミエリンイメージング

Outline of Final Research Achievements

In this study, we have been investigating using 11C-MeDAS, which has already been reported as a myelin-specific PET probe, for the diagnosis of demyelinating diseases such as multiple sclerosis using model animals. Experimental autoimmune encephalomyelitis rats were used to study 11C-MeDAS PET experiments and connectivity using brain slices, but no change in accumulation in demyelinating lesions was observed. As a factor that 11 C - MeDAS did not show sufficient specificity and quantitativeness, 11 C - MeDAS was chemically unstable under radiolabeling conditions, and it was thought that a radiolytic product was easily generated. We began to develop a novel diamine tracer that converted the stilbene skeleton, which is considered to be one of causes of destabilization, to a structure expected to be stable under radiolabeling conditions.

Research Products

• [Journal Article] A single intraperitoneal injection of endotoxin changes glial cells in rats as revealed by positron emission tomography using [11C]PK11195. (2018)
  • Author(s): Ota M, Ogura J, Ogawa S, Kato K, Matsuda H, Kunugi H
  • Journal Title: Nucl Med Mol Imaging Volume: 1 Issue: 3 Pages: 1-5
  • DOI: 10.1007/s13139-017-0510-9
  • Peer Reviewed
• [Journal Article] White matter abnormalities in patients with temporal lobe epilepsy and amygdala enlargement: Comparison with hippocampal sclerosis and healthy subjects. (2016)
  • Author(s): Sone D, Ota M, Maikusa N, Kimura Y, Sumida K, Yokoyama K, Imabayashi E, Watanabe M, Watanabe Y, Okazaki M, Sato N, Matsuda H.
  • Journal Title: Epilepsy Res. Volume: 127 Pages: 221-228
  • DOI: 10.1016/j.eplepsyres.2016.09.011
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 多発性硬化症のPET診断 (2015)
  • Author(s): 宿里充穂、 加藤孝一、 花川隆
  • Journal Title: PET journal Volume: 31 Pages: 32-34
• [Presentation] Utility of 18F-THK5351 PET in diagnosis and differentiation of neurodegenerative disease (2017)
  • Author(s): Imabayashi E, Sone D, Takano H, Tsukamoto T, Shimizu S, Hanyu H, Okamura N, Furumoto S, Kudo Y, Matsuda H.
  • Organizer: Alzheimer’s Association International Conference 2017
  • Int'l Joint Research
• [Presentation] Multimodal imaging correlations in early Alzheimer’s disease : amyloid, tau and neurite imaging (2017)
  • Author(s): Sone D, Imabayashi E, Maikusa N, Matsuda H
  • Organizer: Alzheimer’s Association International Conference 2017
  • Int'l Joint Research