| Project/Area Number |
15K09981
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
Matsuda Hiroshi 国立研究開発法人国立精神・神経医療研究センター, 脳病態統合イメージングセンター, センター長 (90173848)
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| Co-Investigator(Kenkyū-buntansha) |
宿里 充穗 昭和薬科大学, 薬学部, 助教 (20525571)
加藤 孝一 国立研究開発法人国立精神・神経医療研究センター, 脳病態統合イメージングセンター, 室長 (50382198)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | PET / ミエリン / ミエリンイメージング |
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| Outline of Final Research Achievements |
In this study, we have been investigating using 11C-MeDAS, which has already been reported as a myelin-specific PET probe, for the diagnosis of demyelinating diseases such as multiple sclerosis using model animals. Experimental autoimmune encephalomyelitis rats were used to study 11C-MeDAS PET experiments and connectivity using brain slices, but no change in accumulation in demyelinating lesions was observed. As a factor that 11 C - MeDAS did not show sufficient specificity and quantitativeness, 11 C - MeDAS was chemically unstable under radiolabeling conditions, and it was thought that a radiolytic product was easily generated. We began to develop a novel diamine tracer that converted the stilbene skeleton, which is considered to be one of causes of destabilization, to a structure expected to be stable under radiolabeling conditions.
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