Development of a biological dose calculation system for spot-scanning proton therapy

• Project/Area Number: 15K09984
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: Taeko Matsuura 北海道大学, 工学研究院, 准教授 (90590266)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 線エネルギー付与 / 陽子線治療 / 放射線生物効果 / 医学物理 / 生物モデル / 移動標的

Outline of Final Research Achievements

This research focused on the spot-scanning proton therapy for tumors that move with respiration. We have established a methodology to calculate the delivered physical dose with the actual clinical setting. The methodology was implemented for the system developed in the AMED project, which enabled us to evaluate the actual dose delivered to patients on a daily basis. In addition, in order to evaluate the biological effect of proton beam with an emphasis on the dependency on the linear energy transfer (LET), we have developed an analytical LET calculation algorithm. This algorithm computes the LET distribution in patients in a few minutes rather than hours as in the Monte Carlo methods, while keeping the sufficiently good accuracy. Finally, since the dose rate can be another factor that influences the biological effect of proton beam we have developed a methodology to calculate the dose rate at arbitrary position in patients and prepared to the subsequent development of the research.

Research Products

• [Journal Article] An Analytical Dose-Averaged LET-Calculation Algorithm Considering the Off-Axis LET Enhancement by Secondary Protons for Spot-Scanning Proton Therapy (2018)
  • Author(s): S. Hirayama, T. Matsuura, U. Hideaki, Y. Fujii, T. Fujii, S. Takao, N. Miyamoto, S. Shimizu, R. Fujimoto, K. Umegaki, H. Shirato
  • Journal Title: Med. Phys. Volume: 掲載決定
  • Peer Reviewed
• [Journal Article] Impact of Real-Time Image Gating on Spot Scanning Proton Therapy for Lung Tumors: A Simulation Study (2017)
  • Author(s): T. Kanehira, T. Matsuura, S. Takao, Y. Matsuzaki, Y. Fujii, T. Fujii, YM. Ito, N. Miyamoto, T. Inoue, N. Katoh, S. Shimizu, K. Umegaki, H. Shirato
  • Journal Title: Int J Radiat Oncol Biol Phys. Volume: 97 Pages: 173-181
  • Peer Reviewed
• [Journal Article] A simulation study on the dosimetric benefit of real-time motion compensation in spot-scanning proton therapy for prostate (2017)
  • Author(s): Y. Fujii, T. Matsuura, S. Takao, Y. Matsuzaki, T. Fujii, N. Miyamoto, K. Umegaki, K. Nishioka, S. Shimizu and H. Shirato
  • Journal Title: Journal of Radiation Research Volume: 58 Issue: 4 Pages: 591-597
  • DOI: 10.1093/jrr/rrx020
  • NAID: 120006346118
  • Peer Reviewed / Open Access
• [Journal Article] Impact of Real-Time Image Gating on Spot Scanning Proton Therapy for Lung Tumors: A Simulation Study. (2017)
  • Author(s): Kanehira T, Matsuura T, Takao S, Matsuzaki Y, Fujii Y, Fujii T, Ito YM, Miyamoto N, Inoue T, Katoh N, Shimizu S, Umegaki K, Shirato H
  • Journal Title: Int J Radiat Oncol Biol Phys. Volume: 97(1) Issue: 1 Pages: 173-181
  • DOI: 10.1016/j.ijrobp.2016.09.027
  • Peer Reviewed / Open Access
• [Journal Article] NTCP modeling analysis of acute hematologic toxicity in whole pelvic radiation therapy for gynecologic malignancies - A dosimetric comparison of IMRT and spot-scanning proton therapy (SSPT). (2016)
  • Author(s): Yoshimura T, Kinoshita R, Onodera S, Toramatsu C, Suzuki R, Ito YM, Takao S, Matsuura T, Matsuzaki Y, Umegaki K, Shirato H, Shimizu S
  • Journal Title: Phys Med. Volume: 32(9) Issue: 9 Pages: 1098-1102
  • DOI: 10.1016/j.ejmp.2016.08.007
  • NAID: 120005972937
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Evaluation of the relative biological effectiveness of spot-scanning proton irradiation in vitro. (2016)
  • Author(s): Maeda K, Yasui H, Matsuura T, Suzuki M, Nam JM, Yamamori T, Inanami O, Shirato H.
  • Journal Title: Journal of Radiation Research Volume: - Issue: 3 Pages: 307-311
  • DOI: 10.1093/jrr/rrv101
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Optimization and evaluation of multiple gating beam delivery in a synchrotron-based proton beam scanning system using a real-time imaging technique. (2016)
  • Author(s): Yamada T, Miyamoto N, Matsuura T, Takao S, Fujii Y, Matsuzaki Y, Koyano H, Umezawa M, Nihongi H, Shimizu S, Shirato H, Umegaki K
  • Journal Title: Phys Med. Volume: 32(7) Issue: 7 Pages: 932-937
  • DOI: 10.1016/j.ejmp.2016.06.002
  • NAID: 120006313432
  • Peer Reviewed / Open Access
• [Journal Article] A nucleoside anticancer drug, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine, induces depth-dependent enhancement of tumor cell death in spread-out bragg peak (SOBP) of proton beam. (2016)
  • Author(s): Maeda K, Yasui H, Yamamori T, Matsuura T, Takao S, Suzuki M, Matsuda A, Inanami O, Shirato H.
  • Journal Title: PLoS One Volume: 11(11) Issue: 11 Pages: e0166848-e0166848
  • DOI: 10.1371/journal.pone.0166848
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Development and evaluation of a short-range applicator for treating superficial moving tumors with respiratory-gated spot-scanning proton therapy using real-time image guidance (2016)
  • Author(s): Taeko Matsuura, Yusuke Fujii, Seishin Takao, Takahiro Yamada, Yuka Matsuzaki, Naoki Miyamoto, Taisuke Takayanagi, Shinichiro Fujitaka, Shinichi Shimizu, Hiroki Shirato
  • Journal Title: Physics in Medicine and Biology Volume: 62 Issue: 4 Pages: 1515-1531
  • DOI: 10.1088/0031-9155/61/4/1515
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Intrafractional baseline shift/drift of lung tumor motion during gated radiotherapy with a real-time tumor-tracking system (2016)
  • Author(s): Seishin Takao, Naoki Miyamoto, Taeko Matsuura, Rikiya Onimaru, Norio Katoh, Tetsuya Inoue, Kenneth Lee Sutherland, Ryusuke Suzuki, Hiroki Shirato, Shinichi Shimizu
  • Journal Title: International Journal of Radiation Oncology Biology Physics Volume: 94(1) Issue: 1 Pages: 172-180
  • DOI: 10.1016/j.ijrobp.2015.09.024
  • Peer Reviewed
• [Journal Article] Development of a wavelength-separated type SOF dosimeter to compensate for the Cerenkov radiation effect (2015)
  • Author(s): Masayori Ishikawa, Naomi Nagase, Taeko Matsuura, Junichi Hiratsuka, Ryusuke Suzuki, Naoki Miyamoto, Kenneth Sutherland, Katsuhisa Fujita, Hiroki Shirato
  • Journal Title: Journal of Radiation Research Volume: 56(2) Issue: 2 Pages: 372-381
  • DOI: 10.1093/jrr/rru106
  • Peer Reviewed
• [Presentation] Development of a System for Evaluating the Actual Dose Distribution in Respiratory-Gated Spot-Scanning Proton Therapy Using Real-Time Image Guidance (2017)
  • Author(s): T. Matsuura, S. Hirayama, H. Koyano, S. Takao, T. Fujii, T. Yamada, Y. Fujii, H. Nihongi, S. Shimizu, K. Umegaki, H. Shirato
  • Organizer: AAPM 59th Annual Meeting
  • Int'l Joint Research
• [Presentation] An initial study on the increase in physical dose and dose averaged LET through collimator scattered protons was performed in spot-scanning (2017)
  • Author(s): T. Matsuura, S. Takao, T. Fujii, S. Hirayama, K. Maeda, K. Ueno, H. Ueda, H. Koyano, K. Umegaki, H. Shirato
  • Organizer: PTCOG56
  • Int'l Joint Research
• [Presentation] No Increase in Biological Effectiveness Through Collimator Scattered Low Energy Protons (2016)
  • Author(s): T Matsuura, S Takao, Y Matsuzaki, Y Fujii, T Fujii, K Maeda, H Ueda, H Koyano, K Umegaki, H Shirato
  • Organizer: 58th AAPM Annual Meeting
  • Place of Presentation: Washington, USA
  • Year and Date: 2016-07-31
  • Int'l Joint Research
• [Presentation] An Initial Comparison Study of Motion Interplay Effects between IMPT and SFUD in Liver Real-time-image Gated, Spot-scanning Proton Beam Therapy (2016)
  • Author(s): T Matsuura, S Takao, Y Matsuzaki, Y Fujii, T Fujii, N Miyamoto, N Kato, S Shimizu, K Umegaki, H Shirato
  • Organizer: 55th PTCOG
  • Place of Presentation: Prague, Czech
  • Year and Date: 2016-05-22
  • Int'l Joint Research
• [Presentation] A Comparison Study of Motion Interplay Effects between IMPT and SFUD (2016)
  • Author(s): 松浦妙子、高尾聖心、松崎有華、藤井祐介、藤井孝明、宮本直樹、加藤徳雄、清水伸一、梅垣菊男、白土博樹
  • Organizer: 第111回日本医学物理学会学術大会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2016-04-14
• [Presentation] Treatment of superficial liver tumors with spot-scanning proton therapy using real-time gating system-comparison between range compensation devices- (2015)
  • Author(s): Taeko Matsuura, Seishin Takao, Yuka Matsuzaki, Yusuke Fujii, Takaaki Fujii, Naoki Miyamoto,Norio Katoh, Shinichi Shimizu, Hiroki Shirato, Kikuo Umegaki
  • Organizer: 7th International 4D Treatment Planning Workshop
  • Place of Presentation: OncoRay, Dresden, Germany
  • Year and Date: 2015-11-26
  • Int'l Joint Research
• [Presentation] Development of An Applicator for Treating Shallow and Moving Tumors with Respiratory-Gated Spot-Scanning Proton Therapy Using Real-Time Image Guidance (2015)
  • Author(s): T Matsuura, Y Fujii , S Takao, T Yamada, Y Matsuzaki, N Miyamoto, T Takayanagi, S Fujitaka, S Shimizu, H Shirato, K Umegaki
  • Organizer: 57th AAPM Annual Meeting
  • Place of Presentation: Anaheim, USA
  • Year and Date: 2015-07-12
  • Int'l Joint Research