| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
This research focused on the spot-scanning proton therapy for tumors that move with respiration. We have established a methodology to calculate the delivered physical dose with the actual clinical setting. The methodology was implemented for the system developed in the AMED project, which enabled us to evaluate the actual dose delivered to patients on a daily basis. In addition, in order to evaluate the biological effect of proton beam with an emphasis on the dependency on the linear energy transfer (LET), we have developed an analytical LET calculation algorithm. This algorithm computes the LET distribution in patients in a few minutes rather than hours as in the Monte Carlo methods, while keeping the sufficiently good accuracy. Finally, since the dose rate can be another factor that influences the biological effect of proton beam we have developed a methodology to calculate the dose rate at arbitrary position in patients and prepared to the subsequent development of the research.
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