Effects of DAMPs from cancer cells exposed to radiation on the properties of cancer cells
| Project/Area Number |
15K09985
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ダメージ関連分子パターン / 放射線曝露細胞由来馴化培地 / 放射線 / 放射線抵抗性 / Nrf2 / 細胞移動能 / p53 / DAMPs / 自然免疫 / 細胞死 / 抗酸化ストレス / 放射線治療 |
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| Outline of Final Research Achievements |
In the present study, we investigated the effects of damaged-associated molecular patterns (DAMPs) from X-irradiated cancer cells on the properties of cancer cells using irradiated cell conditioned medium (ICCM) containing DAMPs. The lung cancer cells pre-treated with ICCM from X-irradiated lung cancer cells were resistant to X-ray irradiation-induced cytotoxicity compared with non-treated control. Furthermore, the treatment with ICCM attenuated the X-ray irradiation-induced decrease in the lung cancer cell migration. Considering these results, there is a possibility that DAMPs contained in ICCM impairs the anti-cancer effects by radiation therapy.
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Report
(4 results)
Research Products
(18 results)
