| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
In the present study, we investigated the effects of damaged-associated molecular patterns (DAMPs) from X-irradiated cancer cells on the properties of cancer cells using irradiated cell conditioned medium (ICCM) containing DAMPs. The lung cancer cells pre-treated with ICCM from X-irradiated lung cancer cells were resistant to X-ray irradiation-induced cytotoxicity compared with non-treated control. Furthermore, the treatment with ICCM attenuated the X-ray irradiation-induced decrease in the lung cancer cell migration. Considering these results, there is a possibility that DAMPs contained in ICCM impairs the anti-cancer effects by radiation therapy.
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