Safety and Effectiveness of Induction Chemotherapy Followed by Brachytherapy for Thick Oral Cancer
| Project/Area Number |
15K09990
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
YOSHIMURA Ryoichi 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (40302864)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 口腔癌 / 導入化学療法 / 小線源治療 / 放射線腫瘍学 |
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| Outline of Final Research Achievements |
To improve the treatment results of brachytherapy for thick oral cancer, we started this study of induction oral-chemotherapy using TS-1 followed by low-dose-rate brachytherapy. The treatment protocol consisted of 1 or 2 cycles of the TS-1 regimen (80-120 mg/day) according to a 2-weeks-on/1-week-off schedule followed by brachytherapy using low-dose-rate Ir-192 pins or Au-198 grains. The primary endpoint was the rate of complications, and the secondary endpoints were the local control rate and the rate of secondary cervical lymph node metastasis.
Between August 2015 and June 2017, 16 patients were enrolled. Although a few patients suffered from renal dysfunction, hepatic dysfunction, severe fatigue, or dermatitis by TS-1, the incidence of complications due to brachytherapy did not increase. The local control rate was the same as that in past reports. However, the rate of cervical lymph node metastasis was correlated with the number of cycles of the TS-1 regimen.
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Report
(4 results)
Research Products
(19 results)
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[Presentation] SAVIを用いた乳癌小線源治療の3施設比較2016
Author(s)
戸田一真,吉村亮一,中川惠子,笹森浩司,野武亮一,久保田一徳,新城秀典,宮浦和徳,加賀美芳和,久保聡,高橋加奈,岡本裕之,伊丹純
Organizer
日本放射線腫瘍学会小線源治療部会
Place of Presentation
ホテルエルセラーン大阪
Year and Date
2016-05-28
Related Report
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