• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Identification of the mechanisms of radioresistance in cancer stem cells.

Research Project

Project/Area Number 15K09994
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionOsaka University

Principal Investigator

OGAWA KAZUHIKO  大阪大学, 医学系研究科, 教授 (40253984)

Co-Investigator(Kenkyū-buntansha) 石井 秀始  大阪大学, 医学系研究科, 特任教授(常勤) (10280736)
木村 正  大阪大学, 医学系研究科, 教授 (90240845)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords癌幹細胞 / 放射線治療 / 子宮頸癌 / 放射線抵抗性 / 標的治療
Outline of Final Research Achievements

This study has investigated the mechanisms of radioresistance concerning uterine cervical cancer stem cells, and explored the innovative treatments for cancer. We have identified the 43 mRNAs and several miRNAs that significantly differed in expressions between cancer stem and non-cancer stem cells. These mRNA includes ADAMT55, FRMD3, COL8A1, and miR-377-3p、has-miR-654-3p in miRNA. Concerning miR-654-3p, significant difference in survivals were observed between patients with high expression and those with low expression usung TCGA database. We will continue the studies especially using the clinical samples in future.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi