Identification of the mechanisms of radioresistance in cancer stem cells.

• Project/Area Number: 15K09994
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Osaka University
• Principal Investigator: OGAWA KAZUHIKO 大阪大学, 医学系研究科, 教授 (40253984)
• Co-Investigator(Kenkyū-buntansha): 石井 秀始 大阪大学, 医学系研究科, 特任教授(常勤) (10280736) ; 木村 正 大阪大学, 医学系研究科, 教授 (90240845)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 癌幹細胞 / 放射線治療 / 子宮頸癌 / 放射線抵抗性 / 標的治療

Outline of Final Research Achievements

This study has investigated the mechanisms of radioresistance concerning uterine cervical cancer stem cells, and explored the innovative treatments for cancer. We have identified the 43 mRNAs and several miRNAs that significantly differed in expressions between cancer stem and non-cancer stem cells. These mRNA includes ADAMT55, FRMD3, COL8A1, and miR-377-3p、has-miR-654-3p in miRNA. Concerning miR-654-3p, significant difference in survivals were observed between patients with high expression and those with low expression usung TCGA database. We will continue the studies especially using the clinical samples in future.