Efficacy of prophylactic functional foods for amelioration of radiation enteropathy and its metabolism

• Project/Area Number: 15K09996
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kobe University
• Principal Investigator: Okamoto Yoshiaki 神戸大学, 医学研究科, 非常勤講師 (20362791)
• Co-Investigator(Kenkyū-buntansha): 赤坂 浩亮 神戸大学, 医学部附属病院, 特命助教 (20707161) ; 佐々木 良平 神戸大学, 医学部附属病院, 教授 (30346267) ; 江島 泰生 獨協医科大学, 医学部, 講師 (70423233) ; 椋本 成俊 神戸大学, 医学部附属病院, 特命技術員 (70634278) ; 吉田 賢史 神戸大学, 医学部附属病院, 特命准教授 (80351906)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: プロフィラクテック食品 / 放射線治療 / 消化管 / 放射線防護 / 還元型Coenzyme Q10 / 消化管障害 / メタボロミクス

Outline of Final Research Achievements

Effective methods to ameliorate radiation enteropathy have not been developed. To address this issue, reduced CoQ10 was investigated as a potential radioprotective, functional dietary supplement.Reduced CoQ10 was accumulated in all sections of the intestine in supplemented mice. Supplementation with CoQ10 was contributed to suppressing production of reactive oxygen species and inhibiting apoptosis in the crypts, leading to preservation of villi structures after the irradiation. Metabomic analyses were performed. Reduced CoQ10 seemed to be a candidate for amelioration of radiation enteropathy

Research Products

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• [Journal Article] Particle Therapy Using Protons or Carbon Ions for Unresectable or Incompletely Resected Bone and Soft Tissue Sarcomas of the Pelvis, (2017)
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• [Journal Article] Sparing of tissue by using micro-slit-beam radiation therapy reduces neurotoxicity compared with broad-beam radiation therapy. (2017)
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• [Journal Article] Dosimetric factors predicting radiation pneumonitis after CyberKnife stereotactic body radiotherapy for peripheral lung cancer. (2016)
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• [Journal Article] Characterization of titanium dioxide nanoparticles modified with polyacrylic acid and H2O2 for use as a novel Radiosensitizer, (2016)
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• [Journal Article] Cause and occurrence timing of osteoradionecrosis of the jaw: a retrospective study focusing on prophylactic tooth extraction, (2016)
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  • Journal Title: Oral and Maxillofacial Surgery, Volume: 20(4) Issue: 4 Pages: 337-342
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• [Journal Article] Prospective Cohort Study of Performance Status and Activities of Daily Living after Surgery for Spinal Metastasis (2016)
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  • Journal Title: Clinical Spine Surgery Volume: - Issue: 8 Pages: E1026-E1032
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• [Journal Article] Titanium peroxide nanoparticles enhanced cytotoxic effects of X-ray irradiation against pancreatic cancer model through reactive oxygen species generation in vitro and in vivo (2016)
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• [Journal Article] Hypofractionated stereotactic radiotherapy for brain metastases from lung cancer : Evaluation of indications and predictors of local control. (2016)
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• [Journal Article] Efficacy of Stereotactic Body Radiotherapy for Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis / Inferior Vena Cava Tumor Thrombosis: Evaluation by Comparison with Conventional Three-Dimensional Conformal Radiotherapy, (2016)
  • Author(s): Yoshiro Matsuo, Kenji Yoshida, Hideki, Nishimura, Yasuo Ejima, Daisuke Miyawaki, Haruka Uezono, Takeaki Ishihara, Hiroshi Mayahara, Takumi Fukumoto, Yonson Ku, Masato Yamaguchi, Koji Sugimoto, and Ryohei Sasaki,
  • Journal Title: J Radiat Res Volume: 57(5) Issue: 5 Pages: 512-523
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• [Journal Article] Radiotherapy for brainstem gliomas in children and adults: A single-institution experience and literature review. (2016)
  • Author(s): Yoshida K, Sulaiman NS, Miyawaki D, Ejima Y, Nishimura H, Ishihara T, Matsuo Y, Nishikawa R, Sasayama T, Hayakawa A, Kohmura E, Sasaki R
  • Journal Title: Asia Pac J Clin Oncol. Volume: Mar 3 Issue: 2 Pages: 1-8
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• [Journal Article] Randomized Trial of Standard Pain Control with or without Gabapentin for Pain Related to Radiation-induced Mucositis in Head and Neck Cancer. (2016)
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  • Journal Title: Auris Nasus Larynx, Volume: 43(6) Issue: 6 Pages: 677-84
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• [Journal Article] FDG-PET/contrast-enhanced CT as a post-treatment tool in head and neck squamous cell carcinoma: comparison with FDG-PET/non-contrast-enhanced CT and contrast-enhanced CT. (2016)
  • Author(s): Suenaga Y, Kitajima K, Ishihara T, Sasaki R, Otsuki N, Nibu KI, Minamikawa T, Kiyota N, Sugimura K.
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• [Journal Article] [(18)F]-FDG PET/CT imaging for detection of nodal metastases in patients with squamous cell carcinoma of the pharynx and larynx: comparison with CT. (2016)
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• [Journal Article] Concomitant chemoradiotherapy for advanced squamous cell carcinoma of temporal bone (2016)
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• [Journal Article] Particle therapy for clinically diagnosed stage I lung cancer: comparison with pathologically proven non-small cell lung cancer. (2015)
  • Author(s): 6.Fujii O, Demizu Y, Hashimoto N, Takagi M, Terashima K, Mima M, Jin D, Nagano F, Katsui K, Okimoto T, Iwata H, Niwa Y, Yamashita T, Akagi T, Daimon T, Sasaki R, Hishikawa Y, Abe M, Murakami M, Fuwa N.
  • Journal Title: Acta Oncol. Volume: 54(3) Issue: 3 Pages: 315-321
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• [Journal Article] Combined IDH1 mutation and MGMT methylation status on long-term survival of patients with cerebral low-grade glioma. (2015)
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  • Journal Title: Clin Neurol Neurosurg. Volume: 138 Pages: 37-44
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• [Journal Article] Short treatment time and excellent treatment outcome in accelerated hyperfractionated radiotherapy for T1 glottic cancer. (2015)
  • Author(s): Tamaki Y, Hieda Y, Yoshida R, Yoshizako T, Fuchiwaki T, Aoi N, Sekihara K,Kitajima K, Kawauchi H, Kitagaki H, Sasaki R, Inomata T.
  • Journal Title: Nagoya J Med Sci. Volume: 77(4) Pages: 585-94
  • NAID: 120005672311
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• [Journal Article] Clinical significance of SUVmax in (18)F-FDG PET/CT scan for detecting nodal metastases in patients with oral squamous cell carcinoma. (2015)
  • Author(s): Kitajima K, Suenaga Y, Minamikawa T, Komori T, Otsuki N, Nibu K, Sasaki R,Itoh T, Sugimura K.
  • Journal Title: Springerplus. Volume: 4 Issue: 1 Pages: 718-718
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  • NAID: 120005690024
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• [Journal Article] The current status and future of radiotherapy for spinal bone metastases. (2015)
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  • Journal Title: J Orthop Sci. Volume: 20(4) Issue: 4 Pages: 585-592
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• [Journal Article] Assessment of Parametrial Response by Growth Pattern in Patients With International Federation of Gynecology and Obstetrics Stage IIB and IIIB Cervical Cancer: Analysis of Patients From a Prospective, Multicenter Trial (EMBRACE). (2015)
  • Author(s): 17.Yoshida K, Jastaniyah N, Sturdza A, Lindegaard J, Segedin B, Mahantshetty U, Rai B, Jürgenliemk-Schulz I, Haie-Meder C, Sasaki R, Pötter R.
  • Journal Title: Int J Radiat Oncol Biol Phys. Volume: 93(4) Issue: 4 Pages: 788-796
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• [Journal Article] Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment. (2015)
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• [Presentation] Stereotactic body radiation therapy for metastatic lung tumors (2017)
  • Author(s): Yoshiaki Okamoto, Keiko Takahara, Tsuyoshi Yamaguchi, Takamitsu Hirayama, Toru Shinohe, Atsushi Tanaka
  • Organizer: 13th International Stereotactic Radiosurgery Society Congress
  • Int'l Joint Research
• [Presentation] 73.Assessment of the threshold dose for radiation fibrosis in thoracic esophageal cancer patients. (2016)
  • Author(s): Yasuo Ejima, Kenji Yoshida, Daisuke Miyawaki, Takeaki Ishihara, Ryo Nishikawa, Hiroki Kawaguchi, Yoshiro Matsuo, Atsuki Ikeda, Masanori Toyoda, Tetsu Nakamura, Ryohei Sasaki,
  • Organizer: The 1st Meeting of the Federation of Asisan Organizations for Radiation Oncology (FARO),
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2016-11-25
  • Int'l Joint Research
• [Presentation] 76.Assessment of Parametrial Response in stage IIB/IIIB Cervical Cancer Patients from EMBRACE, (2016)
  • Author(s): Kenji Yoshida, Ryohei Sasaki,
  • Organizer: the 4th Taiwan-Japan Radiation Oncology Symposium.
  • Place of Presentation: Taipei Taiwan
  • Year and Date: 2016-06-04
  • Int'l Joint Research
• [Presentation] 77.Space Modulated Particle Therapy with Newly Invented Bio-absorbable Spacer. (2016)
  • Author(s): Ryohei Sasaki, Hiroaki Akasaka, Sachiko Inubushi, Tianyuan Wang, Yasuyuki Shimizu, Saki Osuga, Yusuke Demizu, Takumi Fukumoto,
  • Organizer: the 4th Taiwan-Japan Radiation Oncology Symposium.
  • Place of Presentation: Taipei Taiwan
  • Year and Date: 2016-06-04
  • Int'l Joint Research
• [Presentation] Development of a new medical device for particle therapy: Experience of bioabsorbable spacer at the stage of clinical test. (2015)
  • Author(s): Ryohei Sasaki, Hiroaki Akasaka, Daisuke Miyawaki, Yusuke Demizu, Shigeru Yamada, Masao Murakami, Takumi Fukumoto
  • Organizer: 日本放射線腫瘍学会
  • Place of Presentation: 群馬
  • Year and Date: 2015-11-19
• [Presentation] Radiosensitizor extracted from Spinach, MGDG, Enhanced the Cytotoxic Effect for Pancreatic Cancer Cells when combined with Radiation Treatment (2015)
  • Author(s): Hiroaki Akasaka, Yasuo Ejima, Kenji Yoshida, Daisuke Miyawaki, Takeaki Ishihara, Yoshiyuki Mizushina and Ryohei Sasaki
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: 京都
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Book] Non-woven Fabrics (2016)
  • Author(s): Ryohei Sasaki, Hiroaki Akasaka, Yusuke Demizu, Sachiko Inubushi, Tianyuan Wang, Takumi Fukumoto.
  • Total Pages: 324
  • Publisher: Intech
• [Book] 耳鼻咽喉科・頭頸部外科研修ノート 改訂第2版、 (2016)
  • Author(s): 佐々木良平
  • Publisher: 診断と治療社
• [Book] 多職種チームで実践する頭頚部がんの化学放射線療法 (2015)
  • Author(s): 丹生健一、佐々木良平、大月直樹、大田史江
  • Total Pages: 263
  • Publisher: 日本看護協会出版会