Ultrahigh dose-rate, "FLASH" irradiation minimizes the side-effects of radiotherapy

• Project/Area Number: 15K09997
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kobe University
• Principal Investigator: MIYAWAKI Daisuke 神戸大学, 医学部附属病院, 特命講師 (30546502)
• Co-Investigator(Kenkyū-buntansha): 佐々木 良平 神戸大学, 医学(系)研究科(研究院), 講師 (30346267) ; 江島 泰生 獨協医科大学, 医学部, 講師 (70423233) ; 椋本 成俊 神戸大学, 医学部附属病院, 特命技術員 (70634278)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 超高線量率X線照射 / 超高線量率Ｘ線照射

Outline of Final Research Achievements

Ultrahigh dose-rate, "FLASH" micro-slit-beam irradiation shifted by a large factor the threshold dose required to initiate lung fibrosis without loss of the antitumor efficiency, suggesting that the method might be used to advantage to reduce the occurrence and severity of early and late complications affecting normal tissue.

Research Products

• [Journal Article] Evaluation of a Small Animal Irradiation System for Animal Experiments Using EBT3 Model GAFCHROMIC Film. (2018)
  • Author(s): Shimizu Y, Akasaka H, Miyawaki D, Mukumoto N, Nakayama M, Wang T, Osuga S, Inubushi S, Yada R, Ejima Y, Yoshida K, Ishihara T, Sasaki R.
  • Journal Title: The Kobe Journal of Medical Sciences Volume: 63
• [Journal Article] Comparison of dosimetric parameters in the treatment planning of magnetic resonance imaging-based intracavitary image-guided adaptive brachytherapy with and without optimization using the central shielding technique. (2018)
  • Author(s): Nishikawa R, Yoshida K, Ebina Y, Omoteda M, Miyawaki D, Ishihara T, Ejima Y, Akasaka H, Satoh H, Kyotani K, Takahashi S, Sasaki R.
  • Journal Title: Journal of Radiation Research Volume: 印刷中 Issue: 3 Pages: 316-326
  • DOI: 10.1093/jrr/rry009
  • NAID: 120006477549
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Application of dual-energy CT to suppression of metal artefact caused by pedicle screw fixation in radiotherapy: a feasibility study using original phantom (2017)
  • Author(s): Wang Tianyuan、Ishihara Takeaki、Kono Atsushi、Yoshida Naoki、Akasaka Hiroaki、Mukumoto Naritoshi、Yada Ryuichi、Ejima Yasuo、Yoshida Kenji、Miyawaki Daisuke、Kakutani Kenichiro、Nishida Kotaro、Negi Noriyuki、Minami Toshiaki、Aoyama Yuuichi、Takahashi Satoru、Sasaki Ryohei
  • Journal Title: Physics in Medicine & Biology Volume: 62 Issue: 15 Pages: 6226-6245
  • DOI: 10.1088/1361-6560/aa7d7f
  • Peer Reviewed / Open Access
• [Journal Article] Sparing of tissue by using micro-slit-beam radiation therapy reduces neurotoxicity compared with broad-beam radiation therapy. (2017)
  • Author(s): Naritoshi Mukumoto, Masao Nakayama, Hiroaki Akasaka, Yasuyuki Shimizu, Saki Osuga, Daisuke Miyawaki, Kenji Yoshida, Yasuo Ejima, Yasushi Miura, Keiji Umetani, Takeshi Kondoh, Ryohei Sasaki,
  • Journal Title: J Radiat Res Volume: 58(1) Issue: 1 Pages: 17-23
  • DOI: 10.1093/jrr/rrw065
  • NAID: 120006220810
  • Peer Reviewed / Open Access
• [Journal Article] Hypofractionated stereotactic radiotherapy for brain metastases from lung cancer : Evaluation of indications and predictors of local control. (2016)
  • Author(s): Ishihara T, Yamada K, Harada A, Isogai K, Tonosaki Y, Demizu Y, Miyawaki D, Yoshida K, Ejima Y, Sasaki R.
  • Journal Title: Strahlenther Onkol. Volume: 192(6) Issue: 6 Pages: 386-393
  • DOI: 10.1007/s00066-016-0963-2
  • Peer Reviewed
• [Journal Article] Efficacy of stereotactic body radiotherapy for hepatocellular carcinoma with portal vein tumor thrombosis/inferior vena cava tumor thrombosis: evaluation by comparison with conventional three-dimensional conformal radiotherapy. (2016)
  • Author(s): Matsuo Y, Yoshida K, Nishimura H, Ejima Y, Miyawaki D, Uezono H, Ishihara T, Mayahara H, Fukumoto T, Ku Y, Yamaguchi M, Sugimoto K, Sasaki R.
  • Journal Title: J Radiat Res. Volume: 57(5) Pages: 512-523
  • Peer Reviewed
• [Journal Article] Efficacy of stereotactic body radiotherapy for hepatocellular carcinoma with portal vein tumor thrombosis/inferior vena cava tumor thrombosis: evaluation by comparison with conventional three-dimensional conformal radiotherapy. (2016)
  • Author(s): Matsuo Y, Yoshida K, Nishimura H, Ejima Y, Miyawaki D, Uezono H, Ishihara T, Mayahara H, Fukumoto T, Ku Y, Yamaguchi M, Sugimoto K, Sasaki R
  • Journal Title: J Radiat Res.
  • Peer Reviewed
• [Journal Article] Radiotherapy for brainstem gliomas in children and adults: A single-institution experience and literature review. (2016)
  • Author(s): Yoshida K, Sulaiman NS, Miyawaki D, Ejima Y, Nishimura H, Ishihara T, Matsuo Y, Nishikawa R, Sasayama T, Hayakawa A, Kohmura E, Sasaki R
  • Journal Title: Asia Pac J Clin Oncol. Volume: Mar 3 Issue: 2 Pages: 1-8
  • DOI: 10.1111/ajco.12451
  • NAID: 120006375924
  • Peer Reviewed / Open Access
• [Presentation] Novel application of Dual Energy CT for the suppression of metal artifact by pedicle screws fixation: a feasibility study ysing original (2017)
  • Author(s): TY wang, T Ishihara, N Yoshida, H Akasaka, N Mukumoto, R Yada, A Kono, S Takahashi, Y Ejima, K Yoshida, D Miyawaki, R Sasaki
  • Organizer: The 5th International Symposium of Training Plan for Oncology Professionals
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2017-02-11
  • Int'l Joint Research
• [Presentation] 上咽頭癌に対する強度変調放射線治療を用いた放射線療法の初期経験 (2017)
  • Author(s): 宮脇 大輔 、石原 武明 、上薗 玄 、吉田 賢史 、清田 直臣、大月 直樹、丹生 健一、佐々木 良平
  • Organizer: 日本放射線腫瘍学会第30回学術大会
• [Presentation] マーカー認識型動体追跡システムにおけるマーカー認識評価 (2017)
  • Author(s): 川村 哲朗、藤井 雄介、都倉 真典、村上 直基、栗山 由紀治、宮脇 大輔 、土師 守
  • Organizer: 日本放射線腫瘍学会第30回学術大会
• [Presentation] 還元型コエンザイムQ10による腸管の有害事象軽減の検討 (2017)
  • Author(s): 清水 康之 、椋本 成俊 、赤坂 浩亮 、矢田 隆一 、王 天縁 、大須賀 彩希 、宮脇 大輔 、佐々木 良平
  • Organizer: 日本放射線腫瘍学会第30回学術大会
• [Presentation] メタボロミクスにおける放射線消化管機能不全指標の解明 (2017)
  • Author(s): 大須賀 彩希 、犬伏 祥子 、赤坂 浩亮 、椋本 成俊 、清水 康之 、王 天縁 、宮脇 大輔 、吉田 賢史 、石原 武明 、佐々木 良平
  • Organizer: 日本放射線腫瘍学会第30回学術大会
• [Presentation] Novel application of Dual Energy CT for the suppression of metal artifact in Radiotherapy (2017)
  • Author(s): 王 天縁 、石原 武明 、吉田 直基、角谷 賢一朗、宮脇 大輔 、吉田 賢史 、赤坂 浩亮 、椋本 成俊 、矢田 隆一 、青山 裕一、高橋 哲、佐々木 良平
  • Organizer: 日本放射線腫瘍学会第30回学術大会
• [Presentation] Risk Group Analyses in Cervical Cancer Patients Based on Residual Tumor Volume and Tumor Reduction Ratio at the Time of Image Guided Adaptive Brachytherapy (2017)
  • Author(s): R. Nishikawa , K. Yoshida , Y. Ebina, M. Omoteda, Y. Ejima , D. Miyawaki , T. Ishihara , S. Takahashi, R. Sasaki
  • Organizer: ASTRO's 59th Annual Meeting
• [Presentation] "当院における低・中リスク前立腺癌に対するヨード永久刺入療法の治療成績 " (2017)
  • Author(s): 吉田 賢史 , 古川 順也, 宮脇 大輔 , 石原 武明 , 上薗 玄 , 赤坂 浩亮 , 西谷 隆治, 藤澤 正人, 佐々木 良平
  • Organizer: 日本放射線腫瘍学会小線源部会第19回学術大会
• [Presentation] Assessment of the Threshold Dose for Radiation Fibrosis in Thoracic Esophageal Cancer Patients (2016)
  • Author(s): Y. Ejima, K. Yoshida, D. Miyawaki, T. Ishihara, R. Nishikawa, H. Kawaguchi, Y. Matsuo, A. Ikeda, M. Toyoda, T. Nakamura, R. Sasaki
  • Organizer: the 1st Meeting of the Federation of Asian Organizations for Radiation Oncology
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2016-11-25
  • Int'l Joint Research
• [Presentation] Effectiveness of micro-slit beam radiation therapy for multiple lung-metastatic tumor (2016)
  • Author(s): Y Wakahara, N Mukumoto, M Nakayama, H Akasaka, RC Uchida, K Umetani, T Ishihara, D Miyawaki, K Yoshida, Y Ejima, R Sasaki
  • Organizer: the 29th Annual Meeting of JASTRO
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2016-11-25
• [Presentation] Comparison of Dosimetric Parameters in the Treatment Planning of MRI-Based Intracavitary Image Guided Adaptive Brachytherapy With and Without Optimization Combined With EBRT Using Central Shield (2016)
  • Author(s): K. Yoshida, D. Miyawaki, R. Nishikawa, H. Akasaka, Y. Matsuo, M. Omoteda, K. Kyotani, H. Satoh, S. Osuga, Y. Shimizu, Y. Ebina, S. Takahashi, R. Sasaki
  • Organizer: 58h Annual Meeting of the American Society for Radiation Oncology
  • Place of Presentation: Boston, USA
  • Year and Date: 2016-09-25
  • Int'l Joint Research
• [Presentation] Response of multiple lung-metastatic tumor to microplanar beam irradiation (2015)
  • Author(s): Naritoshi Mukumoto, Masao Nakayama, Hiroaki Akasaka, Ray Cory Uchida, Keiji Umetani, Nobuteru Nariyama, Takeaki Ishihara, Daisuke Miyawaki, Kenji Yoshida, Yasuo Ejima, Ryohei Sasaki
  • Organizer: 日本放射線腫瘍学会第28回学術大会
  • Place of Presentation: 前橋、群馬
  • Year and Date: 2015-11-19
• [Presentation] Radiation Induced Hypothyroidism in Squamous Cell Carcinoma of the Head and Neck: a Dose-Volume Histogram Analysis (2015)
  • Author(s): D. Miyawaki, N. Mukumoto, Y. Ejima, K. Yoshida, T. Ishihara, N. Kiyota, M. Saito, N. Otsuki, K. Nibu, R. Sasaki
  • Organizer: 57th Annual Meeting of ASTRO
  • Place of Presentation: San Antonio, USA
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] Radiotherapy for posterior pharyngeal wall cancer of oropharynx and/or hypopharynx (2015)
  • Author(s): Daisuke Miyawaki, Yasuo Ejima, Kenji Yoshida, Takeaki Ishihara, Naomi Kiyota, Miki Saito, Naoki Otsuki, Ken-ichi Nibu, Ryohei Sasaki
  • Organizer: 4th Congress of Asian Society of Head and Neck Oncology, 39th Annual Meeting of Japan Society for Head and Neck Cancer
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2015-06-04
• [Presentation] Next-stage Bioabsorbable Spacer in Particle Therapy (2015)
  • Author(s): T.Y. Wang, H. Akasaka, Y. Ejima, K.Yoshida,D.Miyawaki,T.Ishihara,N.Mukumoto,T.Fukumoto,R.Sasaki
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] Radioimmunotherapy with 90Y ibritumomab tiuxetan for low grade malignant lymphoma. (2015)
  • Author(s): Ryo Nishikawa, Kenji Yoshida, Daisuke Miyawaki, Yasuo Ejima, Takeaki Ishihara, Yoshiro Matsuo, Nor Shazrina, Yuko Inoue, Hideki Nishimura, Naomi Kiyota, Miki Saito, Naoki Otsuki, Ken-ihci Nibu, Ryohei Sasaki
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] Radiation Induced Hypothyroidism in Squamous Cell Carcinoma of the Head and Neck (2015)
  • Author(s): Daisuke Miyawaki, Yasuo Ejima, Kenji Yoshida, Takeaki Ishihara, Naomi Kiyota, Miki Saito, Naoki Otsuki, Ken-ichi Nibu, Ryohei Sasaki
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] Tolerance for Micro-slit beam X-ray radiation to Central Nervous System (2015)
  • Author(s): Naritoshi Mukumoto, Hiroaki Akasaka, Masao Nakayama, Yasushi Miura, Daisuke Miyawaki, Keiji Umetani, Nobuteru Nariyama, Kunio Shinohara, Takeshi Kondoh, Ryohei Sasaki
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2015-05-25
  • Int'l Joint Research