Development of methods predicting radiosensitivity that can be clinically applied

• Project/Area Number: 15K10000
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Sapporo Medical University
• Principal Investigator: Sakata Koh-ichi 札幌医科大学, 医学部, 教授 (10235153)
• Co-Investigator(Kenkyū-buntansha): 北川 未央 札幌医科大学, 医学部, 研究員 (30608922) ; 福島 悠希 札幌医科大学, 医学部, 研究員 (60749787) ; 土屋 高旭 札幌医科大学, 医学部, 研究員 (90631169) ; 菱山 真史 札幌医科大学, 医学部, 研究員 (00808157)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 放射線感受性 / 予測法 / 免疫組織染色 / DNA損傷修復関連蛋白 / 放射線治療 / 中咽頭癌 / 腫瘍免疫 / 前立腺癌 / DNA修復 / 子宮頸癌

Outline of Final Research Achievements

We developed a practical method for predicting radiosensitivity to realize individualized radiotherapy according to the biological characteristics of cancer cells.
In uterine cervical cancer and prostate cancer, the correlation between expression proteins involved in repair of DNA double-strand breaks of tumor cells by biopsy specimens and radiotherapy results is analyzed, which is a predictive factor of therapeutic effect.
In uterine cervical cancer, the expression rates of Ku 86 and XRCC 4 were predictors of the radiotherapeutic effect on cervical cancer. In prostate cancer, the expression of Ku70 in prostate cancer cells is a prognostic factor independent of clinical factors, and it has been shown that in addition to the prognostic factors presently used in clinical practice, recurrence after radiation treatment can be predicted with high accuracy.

Research Products

• [Journal Article] Influence of XRCC4 expression in esophageal cancer cells on the response to radiotherapy. (2017)
  • Author(s): Hori M, Someya M, Matsumoto Y, Nakata K, Kitagawa M, Hasegawa T, Tsuchiya T, Fukushima Y, Gocho T, Sato Y, Ohnuma H, Kato J, Sugita S, Hasegawa T, Sakata K.
  • Journal Title: Medical Molecular Morphology Volume: 50 Issue: 1 Pages: 25-33
  • DOI: 10.1007/s00795-016-0144-5
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Local tumor control and DNA-PK activity of peripheral blood lymphocytes in prostate cancer patients receiving radiotherapy. (2016)
  • Author(s): Someya M, Hasegawa T, Hori M, Matsumoto Y, Nakata K, Masumori N, Sakata K.
  • Journal Title: Journal of Radiation Research Volume: 58 Issue: 2 Pages: 225-231
  • DOI: 10.1093/jrr/rrw099
  • Peer Reviewed / Open Access
• [Journal Article] Influence of Ku86 and XRCC4 expression in uterine cervical cancer on the response to preoperative radiotherapy (2016)
  • Author(s): TAKADA Yu et al.
  • Journal Title: Med Mol Morphol Volume: 印刷中 Issue: 4 Pages: 1-7
  • DOI: 10.1007/s00795-016-0136-5
  • Peer Reviewed
• [Journal Article] Expression of Ku70 predicts results of radiotherapy in prostate cancer. (2016)
  • Author(s): Hasegawa T, Someya M, Hori M, Matsumoto Y, Nakata K, Nojima M, Kitagawa M, Tsuchiya T, Masumori N, Hasegawa T, Sakata K.
  • Journal Title: Strahlentherapie und Onkologie Volume: 193 Issue: 1 Pages: 29-37
  • DOI: 10.1007/s00066-016-1023-7
  • Peer Reviewed
• [Presentation] 中咽頭癌の治療成績ならびにHPV感染と免疫染色の関連性 (2017)
  • Author(s): 福島悠希，染谷正則，中田健生，堀正和，北川未央，土屋高旭，長谷川智一，後町俊夫，松本健一，坂田耕一，高田優，池田光
  • Organizer: 第43回北海道頭頸部腫瘍研究会
• [Presentation] 中咽頭癌腫瘍細胞におけるヒトパピローマウイルス感染とXRCC4の発現の関連性 (2016)
  • Author(s): 福島悠希，染谷正則，中田健生，堀正和，北川未央，土屋高旭，後町俊夫，坂田耕一
  • Organizer: 日本放射線腫瘍学会第29回学術大会
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2016-11-27
• [Presentation] Influence of Ku86 and XRCC4 expression in uterine cervical cancer on the response to preoperative radiotherapy (2015)
  • Author(s): 高田優
  • Organizer: 第28回日本放射線腫瘍学会
  • Place of Presentation: ベイシア文化ホール（群馬県前橋市）
  • Year and Date: 2015-11-20