Prediction of local tumor control and acute radiation toxicity in pelvic cancer patients using lymphocyte biomarker.

• Project/Area Number: 15K10001
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Sapporo Medical University
• Principal Investigator: Someya Masanori 札幌医科大学, 医学部, 講師 (60404711)
• Co-Investigator(Kenkyū-buntansha): 長谷川 智一 札幌医科大学, 医学部, 研究員 (80631168) ; 後町 俊夫 札幌医科大学, 医学部, 研究員 (80723402) ; 松本 健一 札幌医科大学, 医学部, 研究員 (60750461)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 放射線治療 / 治療効果予測 / 有害事象予測 / 前立腺癌 / 放射線 / バイオマーカー

Outline of Final Research Achievements

To predict individual treatment effects and acute toxicity of patients who underwent pelvic radiation therapy, blood lymphocytes were collected from 141 patients who underwent definitive radiation therapy for non metastatic prostate cancer at our hospital, we measured the DNA-dependent protein kinase (DNA-PK) activity, which is considered to be involved in DNA damage repair, and the expression analysis of microRNA-410, 221 and 99a. As a result, we showed that the DNA-PK activity of lymphocytes was a significant predictor of biochemical relapse in prostate cancer patients and that a combination of miRNA-410 and 221 predicted acute gastrointestinal toxicities with higher accuracy than conventional dose-volume histogram analysis.

Research Products

• [Journal Article] Prediction of acute gastrointestinal and genitourinary radiation toxicity in prostate cancer patients using lymphocyte microRNA. (2018)
  • Author(s): Someya M, Hori M, Gocho T, Nakata K, Tsuchiya T, Kitagawa M, Hasegawa T, Fukushima Y and Sakata KI
  • Journal Title: Japanese journal of clinical oncology Volume: 48(2) Issue: 2 Pages: 167-174
  • DOI: 10.1093/jjco/hyx181
  • Peer Reviewed / Open Access
• [Journal Article] Differential diagnosis between intraductal papillary mucinous neoplasm with an associated invasive carcinoma and pancreatic ductal adenocarcinoma on ultrasonography: the utility of echo intensity and contrast enhancement. (2017)
  • Author(s): Masato Saito, Naoki Hirokawa, Yoko Usami, Masanori Someya, Koh-ichi Sakata
  • Journal Title: Ultrasonography Volume: Feb 4 Issue: 3 Pages: 1-10
  • DOI: 10.14366/usg.16039
  • Peer Reviewed
• [Journal Article] Influence of XRCC4 expression in esophageal cancer cells on the response to radiotherapy. (2017)
  • Author(s): Hori M, Someya M, Matsumoto Y, Nakata K, Kitagawa M, Hasegawa T, Tsuchiya T, Fukushima Y, Gocho T, Sato Y, Ohnuma H, Kato J, Sugita S, Hasegawa T, Sakata K.
  • Journal Title: Medical Molecular Morphology Volume: 50 Issue: 1 Pages: 25-33
  • DOI: 10.1007/s00795-016-0144-5
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Method for Converting Cone-Beam CT Values into Hounsfield Units for Radiation Treatment Planning (2017)
  • Author(s): Tadanori Abe, Kunihiko Tateoka, Yuichi Saito, Takuya Nakazawa, Masaki Yano, Kensei Nakata, Masanori Someya, Masakazu Hori, Koichi Sakata.
  • Journal Title: International Journal of Medical Physics, Clinical Engineering and Radiation Oncology Volume: 6 Issue: 04 Pages: 1-15
  • DOI: 10.4236/ijmpcero.2017.64032
  • Peer Reviewed
• [Journal Article] Expression of Ku70 predicts results of radiotherapy in prostate cancer. (2016)
  • Author(s): Hasegawa T, Someya M, Hori M, Matsumoto Y, Nakata K, Nojima M, Kitagawa M, Tsuchiya T, Masumori N, Hasegawa T, Sakata K.
  • Journal Title: Strahlentherapie und Onkologie Volume: 193 Issue: 1 Pages: 29-37
  • DOI: 10.1007/s00066-016-1023-7
  • Peer Reviewed
• [Journal Article] Local tumor control and DNA-PK activity of peripheral blood lymphocytes in prostate cancer patients receiving radiotherapy. (2016)
  • Author(s): Someya M, Hasegawa T, Hori M, Matsumoto Y, Nakata K, Masumori N, Sakata K.
  • Journal Title: Journal of Radiation Research Volume: 58 Issue: 2 Pages: 225-231
  • DOI: 10.1093/jrr/rrw099
  • Peer Reviewed / Open Access
• [Journal Article] Influence of Ku86 and XRCC4 expression in uterine cervical cancer on the response to preoperative radiotherapy (2016)
  • Author(s): TAKADA Yu et al.
  • Journal Title: Med Mol Morphol Volume: 印刷中 Issue: 4 Pages: 1-7
  • DOI: 10.1007/s00795-016-0136-5
  • Peer Reviewed
• [Journal Article] The expression of Ku70 predicts results of radiotherapy in prostate cancer. (2016)
  • Author(s): Tomokazu Hasegawa, Masanori Someya, Koh-ichi Sakata
  • Journal Title: Strahlentherapie und Onkologie Volume: in press
  • Peer Reviewed
• [Presentation] 血中のエクソソーム内包マイクロRNA解析によるがん放射線治療の効果予測 (2018)
  • Author(s): 染谷正則
  • Organizer: 第11回Quantum Medicine研究会
  • Invited
• [Presentation] がん患者の放射線治療による予後とQOL、晩期の放射線誘発2次癌について (2017)
  • Author(s): 染谷正則
  • Organizer: 第10回Quantum Medicine研究会
  • Invited
• [Presentation] 子宮頸癌の放射線治療成績と末梢血リンパ球のDNA-PK活性の関係 (2017)
  • Author(s): 染谷正則、松本健一、福島悠希、後町俊夫、土屋高旭、長谷川智一、北川未央、堀正和、中田健生、坂田耕一
  • Organizer: 第55回日本放射線腫瘍学会生物部会学術大会
• [Presentation] 前立腺癌放射線治療患者のリンパ球を用いた消化管および尿路の急性期有害事 象予測 (2017)
  • Author(s): 染谷正則、堀正和、長谷川智一、中田健生、土屋高旭、北川未央、後町俊夫、福島悠希、舛森直哉、坂田耕一
  • Organizer: 第55回日本癌治療学会学術集会
• [Presentation] がん患者の放射線治療による予後とＱＯＬ晩期の放射線誘発２次癌について (2017)
  • Author(s): 染谷正則
  • Organizer: 第10回Quantum Medicine研究会
  • Place of Presentation: 茨城県水戸市 茨城大学理学部
  • Invited
• [Presentation] 前立腺癌放射線治療患者の リンパ細胞を用いた急性期有害事象予測 (2016)
  • Author(s): 染谷正則、堀正和、長谷川智一、土屋高旭、北川未央、中田健生、坂田耕一
  • Organizer: 第29回日本放射線腫瘍学会学術大会
  • Place of Presentation: 京都府京都市 国立京都国際会館
  • Year and Date: 2016-11-23
• [Presentation] 子宮頸癌の放射線治療成績と 末梢血リンパ球のDNA-PK活性の関係 (2016)
  • Author(s): 染谷正則、松本健一、福島悠希、後町俊夫、 土屋高旭、長谷川智一、北川未央、堀正和、 中田健生、坂田耕一
  • Organizer: 第135回日本医学放射線学会北日本地方会
  • Place of Presentation: 宮城県仙台市 艮陵会館
  • Year and Date: 2016-10-28
• [Presentation] 前立腺癌放射線治療患者のリンパ細胞 を用いた急性期有害事象予測 (2016)
  • Author(s): 染谷正則、堀正和、中田健生、坂田耕一
  • Organizer: 第54回日本放射線腫瘍学会生物部会学術大会
  • Place of Presentation: 大阪府大阪市 I-siteなんば
  • Year and Date: 2016-07-15
• [Presentation] 食道扁平上皮癌のXRCC4タンパク発現と化学放射線治療の予後の相関 (2016)
  • Author(s): 染谷正則、堀正和、中田健生、北川未央、土屋高旭、坂田耕一
  • Organizer: 第49回制癌剤適応研究会
  • Place of Presentation: 福島県会津若松市御宿東鳳
  • Year and Date: 2016-03-25
  • Invited
• [Presentation] 前立腺癌放射線治療患者のリンパ細胞を用いた急性期有害事象予測 (2016)
  • Author(s): 染谷正則、坂田耕一
  • Organizer: 第9回Quantum medicine研究会
  • Place of Presentation: 茨城県水戸市茨城大学理学部
  • Year and Date: 2016-03-13
  • Invited
• [Presentation] 放射線治療後の前立腺癌患者の末梢血リンパ球DNA-PK活性とPSA再発の関係 (2015)
  • Author(s): 染谷正則、堀正和、中田健生、坂田耕一
  • Organizer: 日本放射線腫瘍学会第28回学術大会
  • Place of Presentation: 群馬県前橋市ベイシア文化ホール
  • Year and Date: 2015-11-19
• [Presentation] Radiosensitization effect of Gimeracil and Olaparib. (2015)
  • Author(s): Masanori Someya
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: 京都市京都国際会館
  • Year and Date: 2015-05-25
  • Int'l Joint Research / Invited
• [Presentation] Relation between Ku80 and microRNA-99a expression and late rectal bleeding after radiotherapy for prostate cancer. (2015)
  • Author(s): Masanori Someya, Masakazu Hori, Kensei Nakata and Koh-ichi Sakata
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: 京都市京都国際会館
  • Year and Date: 2015-05-25
  • Int'l Joint Research