Basic and translational study for the establishment of the immuno-radiotherapy
| Project/Area Number |
15K10003
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
野田 真永 埼玉医科大学, 医学部, 教授 (60396645)
佐藤 浩央 群馬大学, 重粒子線医学推進機構, 助教 (90750571)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 腫瘍免疫 / 放射線治療 / 神経膠芽腫 |
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| Outline of Final Research Achievements |
By the combination therapy (immunoradiometric therapy) of radiation therapy and the therapy (immune checkpoint repressors) of immunity, I put an important point for the activation of the particularly T cell-related immunity for the purpose of the development of the new cure that aimed at the reinforcement of the local site effect of treatment and the radiation therapy for the remote metastatic focus by the activation for local and systemic antitumor immunity and targeted cytotoxic T lymphocyte and the intratumoral permeation. For a glioblastoma and cancer of the esophagus patients, I analyzed a biopsy tumor tissue by immunohistochemistry dyeing. While the in-hospital IRB is approved about this study, and the making of the graft for analysis is finished from a paraffin block and, about onset of HLA class I, T-TIL, onset of PD-L1, confirms the most suitable dyeing condition and enforces analysis now.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells2017
Author(s)
Sato Hiro、Niimi Atsuko、Yasuhara Takaaki、Permata Tiara Bunga Mayang、Hagiwara Yoshihiko、Isono Mayu、Nuryadi Endang、Sekine Ryota、Oike Takahiro、Kakoti Sangeeta、Yoshimoto Yuya、Held Kathryn D.、Suzuki Yoshiyuki、Kono Koji、Miyagawa Kiyoshi、Nakano Takashi、Shibata Atsushi
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Journal Title
Nature Communications
Volume: 8
Issue: 1
Pages: 1751-1751
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Carbon-ion beams induce production of an immune mediator protein, high mobility group box 1, at levels comparable with X-ray irradiation.2015
Author(s)
Yoshimoto Y, Oike T, Okonogi N, Suzuki Y, Ando K, Sato H, Noda SE, Isono M, Mimura K, Kono K, Nakano T
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Journal Title
J Radiat Res
Volume: 56
Issue: 3
Pages: 509-514
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Radio-sensitization effect of an mTOR inhibitor, temsirolimus, on lung adenocarcinoma A549 cells under normoxic and hypoxic conditions.2015
Author(s)
Ushijima H, Suzuki Y, Oike T, Komachi M, Yoshimoto Y, Ando K, Okonogi N, Sato H, Noda SE, Saito J, Nakano T.
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Journal Title
J Radiat Res.
Volume: 56
Issue: 4
Pages: 663-668
DOI
Related Report
Peer Reviewed
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