Development of an evaluation model of residual liver function after proton beam therapy based on cell function localization

• Project/Area Number: 15K10005
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Nagoya City University
• Principal Investigator: Ogino Hiroyuki 名古屋市立大学, 大学院医学研究科, 高度医療教育研究センター教授 (60315885)
• Co-Investigator(Kenkyū-buntansha): 芝本 雄太 名古屋市立大学, 大学院医学研究科, 教授 (20144719) ; 岩田 宏満 名古屋市立大学, 医学(系)研究科(研究院), 助教 (40611588) ; 原 眞咲 名古屋市立大学, 大学院医学研究科, 高度医療教育研究センター教授 (50244562)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 肝細胞癌 / 陽子線治療 / 肝臓がん / 予測モデル

Outline of Final Research Achievements

We evaluated the functional localization in the liver associated with proton beam therapy with the goal of safely performing proton beam therapy for hepatocellular carcinoma. As a result, it was found that liver function by proton beam irradiation can be clarified by MRI signal change. In addition, safety and effectiveness of gold marker indwelling surgery was evaluated for safe and accurate proton therapy. As a result, it became clear that marker placement with a 25 G small diameter needle can be performed without anesthesia

Research Products

• [Journal Article] New technique of percutaneous CT fluoroscopy-guided marking before video-assisted thoracoscopic surgery for small lung lesions: feasibility of using a 25-gauge needle without local anaesthesia. (2018)
  • Author(s): Shimamura Y, Sasaki S, Shimohira M, Ogino H, Yuki D, Nakamae K, Hara M, Shibamoto Y.
  • Journal Title: Br J Radiol. 2018 Volume: 印刷中 Issue: 1083
  • DOI: 10.1259/bjr.20170692
  • Peer Reviewed
• [Journal Article] Acute toxicity of image-guided hypofractionated proton therapy for localized prostate cancer. (2018)
  • Author(s): Nakajima K, Iwata H, Ogino H, Hattori Y, Hashimoto S, Nakanishi M, Toshito T, Umemoto Y, Iwatsuki S, Shibamoto Y, Mizoe JE.
  • Journal Title: Int J Clin Oncol Volume: 23 Issue: 2 Pages: 353-360
  • DOI: 10.1007/s10147-017-1209-8
  • Peer Reviewed
• [Journal Article] Recovery from sublethal damage and potentially lethal damage. Proton beam irradiation vs. X-ray irradiation (2018)
  • Author(s): Shingo Hashimoto, Chikao Sugie, Hiromitsu Iwata, Hiroyuki Ogino, Chihiro Omachi, Keisuke Yasui, Jun-etsu Mizoe, Yuta Shibamoto
  • Journal Title: Strahlentherapie und Onkologie Volume: 194 Issue: 4 Pages: 343-351
  • DOI: 10.1007/s00066-017-1223-9
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Percutaneous fiducial marker placement prior to stereotactic body radiotherapy for malignant liver tumors: an initial experience. (2016)
  • Author(s): Ohta , Shimohira , Murai , Nishimura , Iwata , Ogino , Hashizume , Shibamoto Y
  • Journal Title: J Radiat Res Volume: ５７ Issue: 2 Pages: 174-177
  • DOI: 10.1093/jrr/rrv099
  • Peer Reviewed / Open Access
• [Journal Article] Spot Scanning and Passive Scattering Proton Therapy: Relative Biological Effectiveness and Oxygen Enhancement Ratio in Cultured Cells (2016)
  • Author(s): Name of Authors Iwata H, Ogino H, Hashimoto S, Yamada M, Shibata H, Yasui K, Toshito T, Omachi C, Tatekawa K, Manabe Y, Mizoe JE, Shibamoto Y
  • Journal Title: International Journal of Radiation Oncology Biology Physics Volume: 95 Issue: 1 Pages: 95-102
  • DOI: 10.1016/j.ijrobp.2016.01.017
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A proton therapy system in Nagoya Proton Therapy Center. (2016)
  • Author(s): Toshito T1,2, Omachi C3,4, Kibe Y3,4, Sugai H3,4, Hayashi K3, Shibata H3, Yasui K3, Tanaka K3, Yamamoto , Yoshida , Nikawa , Asai , Shimomura , Okumura , Suzuki , Kinou , Isoyama , Ogino , Iwata , Shibamoto , Mizoe J
  • Journal Title: Australas Phys Eng Sci Med. Volume: 39 Issue: 3 Pages: 645-654
  • DOI: 10.1007/s13246-016-0456-8
  • Peer Reviewed
• [Presentation] Gd-EOB-DTPA enhanced MRI for hepatocellular carcinomas after proton beam therapy (2018)
  • Author(s): Ogino H, Iwata H, Hattori Y, Hashimoto S, Nakajima K, Sasaki S, Shibamoto Y
  • Organizer: European congress of radiology 2018
  • Int'l Joint Research
• [Presentation] Evaluation of prostate fiducial marker placement using 22-gauge needle without local anesthesia (2018)
  • Author(s): Ogino H, Iwata H, Hattori Y, Hashimoto S, Nakajima K, Sugie C, Shibamoto Y
  • Organizer: European congress of radiology 2018
  • Int'l Joint Research
• [Presentation] Proton Beam Therapy for Locally Recurrent Hepatocellular Carcinoma after Radiofrequency Ablation or Transcatheter Arterial Chemoembolization  (2017)
  • Author(s): Shingo Hashimoto, Hiroyuki Ogino, Hiromitsu Iwata, Yukiko Hattori, Koichiro Nakajima, Mikiko Nakanishi, Fumiya Baba, Shigeru Sasaki, Yoshiyuki Kuwabara, Kyoji Senoo, Yuta Shibamoto, Jun-etsu Mizoe 
  • Organizer: ASTRO Annual Meeting
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2017-09-24
  • Int'l Joint Research
• [Presentation] Efficacy of Proton Beam Therapy for Hepatocellular Carcinoma with Portal Vein or Inferior Vena Cava Tumor Thrombosis  (2017)
  • Author(s): Shingo Hashimoto, Hiroyuki Ogino, Hiromitsu Iwata, Yukiko Hattori, Koichiro Nakajima, Mikiko Nakanishi, Fumiya Baba, Shigeru Sasaki, Yasuteru Shimamura, Yoshiyuki Kuwabara, Kyoji Senoo, Yuta Shibamoto, Jun-etsu Mizoe 
  • Organizer: ASTRO Annual Meeting
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2017-09-24
  • Int'l Joint Research
• [Presentation] Transient increases of serum AFP and PIVKA-II levels after proton therapy do not necessarily indicate progression of hepatocellular carcinoma (2017)
  • Author(s): Maiko Yoshida, Hiroyuki Ogino, Hiromitsu Iwata, Yukiko Hattori et al.
  • Organizer: ASTRO Annual Meeting
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2017-09-24
  • Int'l Joint Research
• [Presentation] Transient Increases of Serum AFP and PIVKA-II Levels After Proton Therapy Do Not Necessarily Indicate Progression of Hepatocellular Carcinoma (2017)
  • Author(s): Yoshida Ｍ, Ogino H, Iwata H, Hattori Y, Hashimoto S, Nakajima K, Senoo K, Kuwabara Y, Sasaki S, Hara M, Sekido Y, Mizoe J.E., Shibamoto Y
  • Organizer: 59ｔｈ American Society for Therapeutic Radiology and Oncology Annual Meeting
  • Int'l Joint Research