Elucidation of biological effects of proton therapy - comparison with X rays

• Project/Area Number: 15K10006
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Nagoya City University
• Principal Investigator: Shibamoto Yuta 名古屋市立大学, 大学院医学研究科, 教授 (20144719)
• Co-Investigator(Kenkyū-buntansha): 村井 太郎 名古屋市立大学, 大学院医学研究科, 助教 (00747602) ; 荻野 浩幸 名古屋市立大学, 大学院医学研究科, 高度医療教育研究センター教授 (60315885) ; 岩田 宏満 名古屋市立大学, 大学院医学研究科, 研究員 (40611588)
• Research Collaborator: Ogino Hiroyuki 名古屋市立大学, 大学院医学研究科, 研究員 (60315885) ; Iwata Hiromitsu 名古屋市立大学, 大学院医学研究科, 研究員 (40611588)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
• Keywords: 陽子線治療 / 生物効果 / 酸素効果 / 潜在的致死障害 / 亜致死障害 / DNA修復 / 放射線生物学 / SLDR / PLDR / 生物学 / 生物学的効果比

Outline of Final Research Achievements

Biological effects of proton beams were investigated in comparison with X rays using cultured cells and fruit flies. Our proton beams had an average relative biological effectiveness (RBE) of about 1.1, but had slightly higher oxygen effects and suppressive effects on sublethal and potentially lethal damage repairs. These were considered to be attributable to the higher proportion of the direct action on DNA. Biological effects of spot scanning irradiation were similar to those of broad beam irradiation. RBE increased at the distal end of the spread-out Bragg peak. Proton beams may have biological advantages over X rays against radioresistant tumors.

Academic Significance and Societal Importance of the Research Achievements

陽子線の生物効果については、ほぼX線の効果と同じというように考えられてきたため、まだ生物効果についての基礎研究が少なかったが、当研究によって、様々な点においてX線との間にある程度の違いがあることが明らかとなった。臨床的には、陽子線がX線に比べて線量分布が良いという点だけでなく、効果においてもX線よりある程度優れていることが示唆された。今後の陽子線治療の臨床において、X線治療との使い分けのために参考になるデータが得られたと考えられる。

Research Products

• [Journal Article] Effect of a Device-Free Compressed Shell Fixation Method on Hepatic Respiratory Movement: Analysis for Respiratory Amplitude of the Liver and Internal Motions of a Fiducial Marker (2019)
  • Author(s): Hashimoto S, Katsurada M, Muramatsu R, Asai K, Tanaka K, Hayashi K, Kibe Y, Nakajima K, Hattori Y, Iwata H, Mizoe JE, Ogino H, Shibamoto Y.
  • Journal Title: Practical Radiation Oncology Volume: 9 Issue: 2 Pages: e149-e155
  • DOI: 10.1016/j.prro.2018.10.001
  • Peer Reviewed
• [Journal Article] Recovery from sublethal damage and potentially lethal damage. Proton beam irradiation vs. X-ray irradiation (2018)
  • Author(s): Shingo Hashimoto, Chikao Sugie, Hiromitsu Iwata, Hiroyuki Ogino, Chihiro Omachi, Keisuke Yasui, Jun-etsu Mizoe, Yuta Shibamoto
  • Journal Title: Strahlentherapie und Onkologie Volume: 194 Issue: 4 Pages: 343-351
  • DOI: 10.1007/s00066-017-1223-9
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Spot Scanning and Passive Scattering Proton Therapy: Relative Biological Effectiveness and Oxygen Enhancement Ratio in Cultured Cells (2016)
  • Author(s): Name of Authors Iwata H, Ogino H, Hashimoto S, Yamada M, Shibata H, Yasui K, Toshito T, Omachi C, Tatekawa K, Manabe Y, Mizoe JE, Shibamoto Y
  • Journal Title: International Journal of Radiation Oncology Biology Physics Volume: 95 Issue: 1 Pages: 95-102
  • DOI: 10.1016/j.ijrobp.2016.01.017
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] Effects of proton beams and X rays on the cell cycle of fluorescent ubiquitination-based cell cycle indicator (Fucci)-expressing cells (2018)
  • Author(s): Hiromitsu Iwata, Yuta Shibamoto 他
  • Organizer: 2018 Annual Meeting of the American Society for Radiation Oncology
  • Int'l Joint Research
• [Presentation] Drosophila Melanogaster as a Model Organism to Study Biological Effects of Proton Radiation (2018)
  • Author(s): Koichiro Nakajima, Yuta Shibamoto 他
  • Organizer: 2018 Annula Meeting of the Particle Therapy Cooperative Group
  • Int'l Joint Research
• [Presentation] Biological Effects of Proton and Photon Therapy in Combination with Cisplatin and Their Possible Mechanisms: an In Vitro Study (2017)
  • Author(s): Hiromitsu Iwata, Shingo Hashimoto, Koichiro Nakajima, Chihiro Omachi, Toshiyuki Toshito, Keisuke Yasui, Chikao Sugie, Hiroyuki Ogino, Jun-etsu Mizoe, Yuta Shibamoto
  • Organizer: 59th Annual Meeting of the American Society for radiation Oncology
  • Int'l Joint Research
• [Presentation] Potentially lethal damage repair and sublethal damage repair after proton beam irradiation (2016)
  • Author(s): Shingo Hashimoto, Chikao Sugie, Hiromitsu Iwata, Hiroyuki Ogino, Chihiro Omachi, Keisuke Yasui, Jun-etsu Mizoe, Yuta Shibamoto
  • Organizer: 日本放射線腫瘍学会 第29回学術大会
  • Place of Presentation: 国立京都国際会館(京都府・京都市)
  • Year and Date: 2016-11-26