A prophylaxis and a treatment for radiation induced mucosal damage by Radioprotector and Radiosensitizer using an animal experimental model -Merits and demerits of oxygen and zinc -

• Project/Area Number: 15K10011
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hyogo Medical University
• Principal Investigator: KAMIKONYA Norihiko 兵庫医科大学, 医学部, 教授 (00185985)
• Co-Investigator(Kenkyū-buntansha): 土井 啓至 近畿大学, 医学部, 講師 (50529047) ; 丹羽 康江 兵庫医科大学, 医学部, 助教 (60648294) ; 高木 治行 兵庫医科大学, 医学部, 助教 (30378377) ; 高田 康弘 兵庫医科大学, 医学部, 助教 (20461048) ; 冨士原 将之 兵庫医科大学, 医学部, 講師 (90388827) ; 廣田 省三 兵庫医科大学, 医学部, 名誉教授 (20181216)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 放射線障害 / 亜鉛 / 高気圧酸素 / 放射線治療 / 直腸粘膜障害 / 抗凝固剤

Outline of Final Research Achievements

Animal experiments were done safely to investigate whether administration of hyperbaric oxygen promotes prophylaxis and treatment for radiation induced mucosal damage.Although the effect which limited [ control / weight reduction ] the effect of the administration of hyperbaric oxygen to the acute phase radiation injury by the animal experiments, the significant difference was not accepted histologically. On the other hand, the effect of the medication after irradiation of a zinc was accepted.Although we had also reported, it was shown this time that medication of the zinc tablet before irradiation is histologically more effective.Results of animal experiments like those of the current study cannot be applied directly to the clinical situation, but we hope that our findings provide to radiation injury can be avoided.

Academic Significance and Societal Importance of the Research Achievements

本研究の目的は、高齢者・糖尿病合併等ハイリスク患者の放射線治療における放射線直腸障害の予防・治癒方法の獲得である。高気圧酸素治療は放射線増感剤として臨床応用され、糖尿病や血管障害による難治性軟部組織壊死、放射線治療後の難治性損傷に対する臨床研究が行われている。代表者らは高気圧酸素の放射線増感作用と、亜鉛の放射線防護作用を併用、高気圧酸素による放射線急性期障害増悪のリスクを亜鉛化合物で軽減し、難治性放射線直腸障害の発生を予防・軽減を期待する。本研究により、高気圧酸素が放射線直腸炎発生に与える影響について解明し、高齢ハイリスク癌放射線治療の安全性・有効性を確立できると考える。

Research Products

• [Journal Article] Pravastatin reduces radiation-induced damage in normal tissues (2017)
  • Author(s): Doi H, Matsumoto S, Odawara S, Shikata T, Kitajima K, Tanooka M, Takada Y, Tsujimura T, Kamikonya N, Hirota S
  • Journal Title: Exp Ther Med. Volume: 13 Issue: 5 Pages: 1765-1772
  • DOI: 10.3892/etm.2017.4192
  • Peer Reviewed / Open Access
• [Journal Article] Thermal ablation and immunomodulation: From preclinical experiments to clinical trials (2017)
  • Author(s): Takaki H, Cornelis F, Kako Y, Kobayashi K, Kamikonya N, Yamakado K. Thermal ablation and immunomodulation: From preclinical experiments to clinical trials
  • Journal Title: Diagn Interv Imaging Volume: 98 Issue: 9 Pages: 651-659
  • DOI: 10.1016/j.diii.2017.04.008
  • Peer Reviewed / Open Access
• [Journal Article] Utility of intraoral stents in external beam radiotherapy for head and neck cancer (2017)
  • Author(s): Doi H, Tanooka M, Ishida T, Moridera K, Ichimiya K, Tarutani K, Kitajima K, Fujiwara M, Kishimoto H, Kamikonya N
  • Journal Title: Rep Pract Oncol Radiother Volume: 22 Issue: 4 Pages: 310-318
  • DOI: 10.1016/j.rpor.2017.03.002
  • Peer Reviewed
• [Journal Article] Clinicopathological outcomes of preoperative chemoradiotherapy using S-1 plus irinotecan for T4 lower rectal cancer． (2016)
  • Author(s): Beppu N, Yoshie H, Kimura F, Aihara T, Doi H, Kamikonya N, Matsubara N, Tomita N, Yanagi H, Yamanaka N.
  • Journal Title: Surg Today Volume: 46 Issue: 2 Pages: 852-859
  • DOI: 10.1016/j.surg.2016.08.013
  • Peer Reviewed
• [Journal Article] Feasibility of estimationg Patient-specific dose verification results directly from linear accelerator log files in volumetric modulated arc therapy. (2016)
  • Author(s): Kosaka K, Tanooka M, Doi H, Inoue H, Tarutani K, Suzuki H, Takada Y, Fujiwara M, Kamikonya N, Hirota S.
  • Journal Title: International Journal of Medical Physics, Clinical Engineering and Radiation Oncology Volume: 5 Issue: 4 Pages: 377-381
  • DOI: 10.3892/mco.2016.983
  • Peer Reviewed
• [Journal Article] Radiotherapy in late elderly (aged 75 or older) patients with paranasal simus carcinoma : a single institution experience． (2016)
  • Author(s): Doi H，Kitajima K，Tanooka M，Terada T，Noguchi K，Takada Y，Fujiwara M，Ishikura R，Kamikonya N，Hirota S．
  • Journal Title: Eur Arch Otorhinolaryngol Volume: 273 Issue: 12 Pages: 4485-4492
  • DOI: 10.1007/s00405-016-4151-x
  • Peer Reviewed / Open Access
• [Presentation] 高気圧酸素療法および亜鉛製剤による急性期放射線障害の抑制効果について (2018)
  • Author(s): 鈴木公美、小田原聡一、丹羽康江、高田康弘、冨士原将之、高木治行、上紺屋憲彦、 山門亨一郎
  • Organizer: 日本放射線腫瘍学会第３１回学術大会
• [Presentation] ・口腔内金属による線量分布への影響（口腔内を想定したファントムによる実測） (2018)
  • Author(s): 冨士原将之、松本利浩、石田敏久、若山司、田和光、村上雄一、源貴裕、鈴木公美、田ノ岡正雄、上紺屋憲彦、山門亨一郎
  • Organizer: 日本放射線腫瘍学会第３１回学術大会
• [Presentation] 亜鉛製剤投与ならびに高気圧酸素療法による急性期放射線障害の抑制効果について (2017)
  • Author(s): 鈴木公美，小田原聡一，丹羽康江，髙田康弘，冨士原将之，高木治行，上紺屋憲彦，山門亨一郎
  • Organizer: 第317回公益社団法人日本医学放射線学会関西地方会
• [Presentation] 亜鉛製剤投与並びに高気圧酸素療法による急性期放射線障害の抑制効果について (2017)
  • Author(s): 鈴木公美，小田原聡一，丹羽康江，髙田康弘，冨士原将之，高木治行，上紺屋憲彦，山門亨一郎
  • Organizer: 日本放射線腫瘍学会第30回学術大会
• [Presentation] 上顎洞扁平上皮癌に対する動注化学放射線療法の予後予測因子 (2017)
  • Author(s): 土井啓至，冨士原将之，北島一宏，田ノ岡征雄，髙田康弘，寺田友紀，野口一馬，石藏礼一，上紺屋憲彦，山門亨一郎
  • Organizer: 日本放射線腫瘍学会第30回学術大会
• [Presentation] 体内金属が線量分布に与える影響 (2017)
  • Author(s): 冨士原将之，田ノ岡征雄，石田敏久，若山司，松本利浩，鈴木公美，樽谷和雄，髙田康弘，土井啓至，上紺屋憲彦，山門亨一郎
  • Organizer: 日本放射線腫瘍学会第30回学術大会
• [Presentation] ログファイルを使用したVMAT線量検証法． (2016)
  • Author(s): 小坂賢吾、田ノ岡征雄、土井啓至、井上裕之、樽谷和雄、鈴木公美、髙田康弘、冨士原将之、上紺屋憲彦、廣田省三．
  • Organizer: 日本放射線腫瘍学会第29回学術大会
  • Place of Presentation: 京都
  • Year and Date: 2016-11-25
• [Presentation] 前立腺癌小線源治療後、経過観察中に生じた他病に関する検討． (2016)
  • Author(s): 髙田康弘、加藤貴、鈴木公美、小田原聡一、土井啓至、冨士原将之、坪井慶太、上紺屋憲彦、Xiuxian Wu、山本新吾、廣田省三．
  • Organizer: 日本放射線腫瘍学会第29回学術大会
  • Place of Presentation: 京都
  • Year and Date: 2016-11-25
• [Presentation] 後期高齢者副鼻腔癌に対する放射線治療経験． (2016)
  • Author(s): 土井啓至、北島一宏、田ノ岡征雄、寺田友紀、野口一馬、上野敬司、樽谷和雄、小坂賢吾、髙田康弘、冨士原将之、石藏礼一、上紺屋憲彦、廣田省三
  • Organizer: 日本放射線腫瘍学会第29回学術大会
  • Place of Presentation: 京都
  • Year and Date: 2016-11-25
• [Presentation] 頭頸部癌における適応放射線治療の画像レジストレーションと再計画予測因子の有用性． (2016)
  • Author(s): 石田敏久、田ノ岡征雄、土井啓至、若山司、井上裕之、酒井敏行、松本利浩、琴浦規子、冨士原将之、上紺屋憲彦．
  • Organizer: 日本放射線腫瘍学会第29回学術大会
  • Place of Presentation: 京都
  • Year and Date: 2016-11-25
• [Presentation] Diffusion-weighted magnetic resonance imaging in prediction of tumor response to neoadjuvant chemoradiotherapy using irinotecan plus S-1 for rectal cancer． (2015)
  • Author(s): 土井啓至，別府直仁，加藤貴，田ノ岡征雄，北島一宏，鈴木公美，樽谷和雄，小坂賢吾，冨田尚裕，上紺屋憲彦，廣田省三
  • Organizer: 日本放射線腫瘍学会第28回学術大会
  • Place of Presentation: ベイシア文化ホール（群馬県前橋市）
  • Year and Date: 2015-11-21
• [Presentation] The incidence of radiation toxicity in salvage radiation therapy for the recurrent prostate cancer after surgery (2015)
  • Author(s): 鈴木公美，丹羽康江，髙田康弘，冨士原将之，土井啓至，小田原聡一，上紺屋憲彦，廣田省三
  • Organizer: 日本放射線腫瘍学会第28回学術大会
  • Place of Presentation: ベイシア文化ホール（群馬県前橋市）
  • Year and Date: 2015-11-20
• [Presentation] Polaprezinc Reduces Radiation Induced Apoptosis in Normal Intestine and the Severity of Radiation Dermatitis in Mice． (2015)
  • Author(s): H. Doi, S. Odawara, T. Shikata, M. Tanooka, H. Suzuki, Y. Niwa, Y. Takada, M. Fujiwara, N. Kamikonya, T. Tsujimura, and S. Hirota
  • Organizer: ASTRO's 57th Annual Meeting
  • Place of Presentation: San Antonio, USA
  • Year and Date: 2015-10-19
  • Int'l Joint Research
• [Presentation] On the Accuracy of Automatic 4-D Tumor Registration Between Planning CT and On-board CBCT Under Different Breathing Conditions: A Phantom Study． (2015)
  • Author(s): Tanooka Masao, Inoue Hiroyuki, Nakajima Hiroki, Harui Shogo, Masai Norihisa, Odawara Soichi, Fujiwara Masayuki, Kosaka Kengo, Tarutani Kazuo, Shibayama Mitsuhiro, Wakayama Tsukasa, Uehigashi Jun, Nakamura Etsuko, Sakai Toshiyuki, Nasada Toshiya, Yasumasa Katsumi, Sakamoto Kiyoshi,
  • Organizer: ASTRO's 57th Annual Meeting
  • Place of Presentation: San Antonio, USA
  • Year and Date: 2015-10-19
  • Int'l Joint Research
• [Presentation] Diffusion-weighted magnetic imaging for the prediction of the tumor response to neoadjuvant chemoradiotherapy using irinotecan plus S-1 for rectal cancer. (2015)
  • Author(s): Doi Hiroshi, Beppu Naohito, Kato Takashi, Tanooka Masao, Kosaka Kengo, Tarutani Kazuo, Suzuki Hitomi, Odawara Soichi, Niwa Yasue, Takada Yasuhiro, Fujiwara Masayuki, M. Noda, N. Tomita, Kamikonya Norihiko, Hirota Shozo
  • Organizer: The European Cancer Congress 2015 (ECC 2015)
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2015-09-26
  • Int'l Joint Research
• [Presentation] Polaprezinc protects normal intestine and skin from radiation-induced damages in mice. (2015)
  • Author(s): Doi Hiroshi, Odawara Soichi, T. Shikata, Tarutani Kazuo, Kosaka Kengo, Suzuki Hitomi, Niwa Yasue, Tsujimura Toru, Kamikonya Norihiko, Hirota Shozo
  • Organizer: The European Cancer Congress 2015 (ECC 2015)
  • Place of Presentation: Vienna,Austria
  • Year and Date: 2015-09-26
  • Int'l Joint Research
• [Presentation] Correlation analysis between pre-treatment verification precision and plan complexity or machine parameters using log files for VMAT delivery. (2015)
  • Author(s): K. Kosaka, M. Tanooka, H. Inoue, K. Tarutani, M. Fujiwara, Y. Niwa, Y. Takada, H. Doi, S. Odawara, H. Suzuki, N. Kamikonya, S. Hirota
  • Organizer: The European Cancer Congress 2015 (ECC 2015)
  • Place of Presentation: Vienna,Austria
  • Year and Date: 2015-09-26
  • Int'l Joint Research
• [Presentation] Pravastatin protects normal intestinal epithelium and normal lung from radiation-induced cell death． (2015)
  • Author(s): Doi Hiroshi, Odawara Soichi, S. Matsumoto, T. Shikata , Suzuki Hitomi, Kato Takashi, Tarutani Kazuo, Kosaka Kengo, Inoue Hiroyuki, Tanooka Masao, Takada Yasuhiro, Tsujimura Tohru, Kamikonya Norhihiko. Hirota Shozo
  • Organizer: The European Cancer Congress 2015 (ECC 2015)
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2015-09-26
  • Int'l Joint Research
• [Presentation] Polaprezinc reduces the severity of radiation induced mucositis : The result of a prospective clinical study and a retrospective comparison study (2015)
  • Author(s): 鈴木公美，土井啓至，冨士原将之，丹羽康江，小田原聡一，髙田康弘，上紺屋憲彦，廣田省三
  • Organizer: 第74回日本医学放射線学会総会
  • Place of Presentation: パシフコ横浜（神奈川県横浜市）
  • Year and Date: 2015-04-18
• [Book] がん・放射線療法2017 (2017)
  • Author(s): 大西洋 (編集), 唐澤久美子 (編集), 唐澤克之 (編集)、上紺屋憲彦、冨士原将之
  • Total Pages: 1255
  • Publisher: 学研プラス
  • ISBN: 9784780909432
• [Book] 不妊・不育診療指針 (2016)
  • Author(s): 柴原浩章
  • Total Pages: 766
  • Publisher: 中外医学社