| Project/Area Number |
15K10018
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
川岸 直樹 東北大学, 大学病院, 准教授 (00333807)
中川 敦寛 東北大学, 大学病院, 特任准教授 (10447162)
中野 徹 東北医科薬科大学, 医学部, 准教授 (50451571)
大谷 清伸 東北大学, 流体科学研究所, 特任准教授 (80536748)
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| Research Collaborator |
YOKOSAWA Tomoki
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | パルスジェット / 腹腔鏡下肝部分切除 / 多ノズル / 肝障害 / 切除条件 / ３穴パルスジェット / 肝逸脱酵素上昇抑制 / 破断応力 / 安全性 / 切除時間 / 血管温存性 / 多穴化 / 組織変性 / パルスジェット先端形状 / 吸引パイプ形状 / 最適駆動電圧 / 組織障害 / 飛沫軽減 / 切除時間短縮 |
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| Outline of Final Research Achievements |
We assessed the feasibility of a newly developed, piezo actuator driven pulsed water jet (ADPJ) for laparoscopic liver resection in swine model. Laparoscopic liver resection was safely performed using ADPJ without increasing surgical duration or blood loss. And we built a prototype of ADPJ with three nozzles to improve resection speed. ADPJ with three nozzles improved resection speed, but it was noted experimentally that its resection speed depends on the driving voltage and pulse frequency. The physical properties of human liver were evaluated. There were significant differences in the breaking strength among three groups (cirrhotic liver parenchyma, hepatic vein, and Glisson’s sheaths). It was suggested that ADPJ can be used for liver resection in cirrhotic patients. Furthermore, animal experiments using rat model showed that ADPJ attenuate hepatic damage more than ultrasonic surgical aspirator after liver resection.
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