Analysis of association between allo-immune response and FOXP3 polymorphism in organ transplantation
| Project/Area Number |
15K10026
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
TANAKA Yuka 広島大学, 医歯薬保健学研究科(医), 准教授 (90432666)
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| Co-Investigator(Kenkyū-buntansha) |
大段 秀樹 広島大学, 医歯薬保健学研究科(医), 教授 (10363061)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 制御性T細胞 / 拒絶反応 / 遺伝子多型 |
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| Outline of Final Research Achievements |
Regulatory T cells expressing the transcription factor Foxp3 are essential for immune homeostasis. This study investigated the impact of FOXP3 SNPs on the severity of ACR in liver transplant (LT) recipients. We did not find any statistical association between the FOXP3 SNPs genotype frequencies and the incidence of ACR. However, significantly higher incidence of SRAR was observed in LT patients with the FOXP3 rs3761548 A/C+A/A genotype than in those with C/C genotype. The total dose of intravenous methylprednisolone used for ACR treatment was significantly higher in the rs3761548 A/C+A/A genotype than that in the C/C genotype. This fact suggests that the immunosuppression regime and/or anti-ACR treatment regimen should be adjusted on an individual basis by identifying FOXP3 SNPs, implying a need for personalized medicine in the field.
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Report
(4 results)
Research Products
(13 results)
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[Presentation] Foxp3遺伝子多型から見たHBV性肝硬変レシピエントの免疫学的特性2015
Author(s)
田中友加, Verma Sapana, 清水誠一, 谷峰直樹, Das Lalit Kumar, 田原裕之, 大平真裕, 井手健太郎, 石山宏平, 小林剛, 田代裕尊, 大段秀樹
Organizer
第51回日本移植学会総会
Place of Presentation
熊本
Year and Date
2015-10-01
Related Report
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