| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Regulatory T cells expressing the transcription factor Foxp3 are essential for immune homeostasis. This study investigated the impact of FOXP3 SNPs on the severity of ACR in liver transplant (LT) recipients. We did not find any statistical association between the FOXP3 SNPs genotype frequencies and the incidence of ACR. However, significantly higher incidence of SRAR was observed in LT patients with the FOXP3 rs3761548 A/C+A/A genotype than in those with C/C genotype. The total dose of intravenous methylprednisolone used for ACR treatment was significantly higher in the rs3761548 A/C+A/A genotype than that in the C/C genotype. This fact suggests that the immunosuppression regime and/or anti-ACR treatment regimen should be adjusted on an individual basis by identifying FOXP3 SNPs, implying a need for personalized medicine in the field.
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