Immune response mediated by hepatic stellate cells with endoplasmic reticulum stress in liver transplantation.

• Project/Area Number: 15K10027
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: The University of Tokushima
• Principal Investigator: ARAKAWA Yusuke 徳島大学, 大学院医歯薬学研究部(医学系), 徳島大学専門研究員 (00448325)
• Co-Investigator(Kenkyū-buntansha): 島田 光生 徳島大学, 大学院医歯薬学研究部(医学系), 教授 (10216070) ; 池本 哲也 徳島大学, 病院, 特任准教授 (20398019) ; 森根 裕二 徳島大学, 大学院医歯薬学研究部(医学系), 准教授 (60398021) ; 居村 暁 徳島大学, 病院, 特任教授 (90380021) ; 親泊 政一 徳島大学, 先端酵素学研究所(プロテオ), 教授 (90502534)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 肝移植 / 肝内免疫 / 肝星細胞 / 小胞体ストレス

Outline of Final Research Achievements

Withdrawal from immunosuppressant by induction of tolerance is the ultimate goal in liver transplantation. It is speculated that together with Kupffer cells, hepatic stellate cells play an important role in maintaining the immune tolerance environment. There have been no reports on intrahepatic immunity and hepatic stellate cells, and its mechanism is unknown. Regarding immune regulation and endoplasmic reticulum stress, the PERK pathway, which is one of the endoplasmic reticulum stress pathways, has been reported to inhibit apoptosis via CHOP induction of macrophages responsible for innate immunity. It is also reported that it is involved in maintaining quality of hematopoietic stem cells. The purpose of this study is to clarify the role of hepatic stellate cells and the involvement of endoplasmic reticulum stress in liver transplantation immunity.

Research Products

• [Journal Article] Mechanism of impairment on liver regeneration in elderly patients: Role of hepatic stellate cell function. (2017)
  • Author(s): Saito Y, Morine Y, Shimada M.
  • Journal Title: Hepatology Research Volume: 印刷中 Issue: 6 Pages: 505-513
  • DOI: 10.1111/hepr.12872
  • Peer Reviewed
• [Journal Article] Complication of portal vein thrombosis after right hemihepatectomy in a patient lacking the portal vein bifurcation. (2016)
  • Author(s): Teraoku H, Arakawa Y, Yoshikawa M, Yamada S, Saito Y, Iwahashi S, Ikemoto T, Morine Y, Imura S, Shimada M.
  • Journal Title: J Med Invest Volume: 63 Issue: 3.4 Pages: 315-318
  • DOI: 10.2152/jmi.63.315
  • NAID: 130005245920
  • Peer Reviewed
• [Journal Article] Liver regeneration after splenectomy in patients with liver cirrhosis. (2016)
  • Author(s): Yamada S, Morine Y, Imura S, Ikemoto T, Arakawa Y, Iwahashi S, Saito Y, Yoshikawa M, Teraoku H, Shimada M.
  • Journal Title: Hepatolgy research Volume: 印刷中 Issue: 5 Pages: 443-449
  • DOI: 10.1111/hepr.12573
  • Peer Reviewed
• [Journal Article] 再発抑制のための抗ウイルス療法 (2015)
  • Author(s): 荒川悠介，島田光生
  • Journal Title: Pharma Medica Volume: 33 Pages: 59-62
• [Presentation] 小胞体ストレス応対に着目した加齢肝再生不全における肝星細胞の役割についての検討 (2015)
  • Author(s): 荒川悠佑,島田光生,吉川雅登,寺奥大貴,山田眞一郎,,齋藤裕,岩橋衆一,池本哲也,森根裕二,居村暁
  • Organizer: 第70回日本消化器外科学会総会
  • Place of Presentation: アクトシティ浜松（静岡県浜松市）
  • Year and Date: 2015-07-15
• [Presentation] 加齢肝再生不全における肝星細胞の役割についての検討 (2015)
  • Author(s): 荒川悠佑,島田光生,寺奥大貴,吉川雅登,石川大地,山田眞一郎,齋藤裕,高須千絵,岩橋衆一,池本哲也,森根裕二,居村暁,東島潤
  • Organizer: 第115回日本外科学会定期学術集会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-04-16