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Development of new multidisciplinary therapy in intractable cancer

Research Project

Project/Area Number 15K10031
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionKagoshima University

Principal Investigator

Ueno Shinichi  鹿児島大学, 鹿児島大学病院, 特例教授 (40322317)

Co-Investigator(Kenkyū-buntansha) 前村 公成  鹿児島大学, 医歯学域医学系, 准教授 (30398292)
迫田 雅彦  鹿児島大学, 医歯学域鹿児島大学病院, 助教 (40418851)
夏越 祥次  鹿児島大学, 医歯学域医学系, 教授 (70237577)
飯野 聡  鹿児島大学, 医歯学域鹿児島大学病院, 助教 (80598003)
樋渡 清司  鹿児島大学, 医学部・歯学部附属病院, 医員 (80721216)
Project Period (FY) 2015-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords癌の集学的治療 / 癌微小環境 / 遺伝子治療 / サバイビン / がんと炎症 / Surv.m-CRA / がん悪液質 / サイトカイン / Surv.m-CRA / Surv. m-CRA
Outline of Final Research Achievements

As for the investigator initiated trial of Surv.m-CRA, the protocol was approved by the Minister of Health, Labour and Welfare, too, and the patient dosage was already started mainly on a saft tumor. In order to clarify the treatment responsibility in relation to the patients'inflammatory state in termes of an immune cell and a cancer stem cell change, the existing tissue sample (control group) and the measurement of cytokine and vascularization instruction factors in this gene therapy were performed. In this gene therapy introduction, the possibility of the treatment-resistance due to the inflammatory reaction:the mitochondrial damage---mitochondrial DNA oxidation (apoptosis)---NLPR3 activation ---IL1B and IL18 secretion ---Th1 type of inflammation (survival and increase of the cancer cell) was suspected.

Academic Significance and Societal Importance of the Research Achievements

骨軟部腫瘍や胆膵癌などの難治癌に対する新規遺伝子治療開発が鹿児島大学小戝健一郎等を中心に行われ、その臨床試験も開始された。この遺伝子治療単独の治療効果に付随して、どのような集学的治療が考えられるか、またその治療抵抗性の検討等も重要な検討課題であるである。本付随研究による学術的意義として、既存資料との対比から、癌細胞の壊死誘導によりプライミングされる免疫炎症反応を抑えることも治療効果に関与しうる点である。

Report

(6 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (9 results)

All 2017 2016 2015

All Journal Article (6 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 6 results,  Open Access: 6 results,  Acknowledgement Compliant: 2 results) Presentation (3 results)

  • [Journal Article] Impact of Snail and E-cadherin expression in pancreatic neuroendocrine tumors.2017

    • Author(s)
      Yonemori K1, Kurahara H1, Maemura K1, Mataki Y1, Sakoda M1, Iino S1, Ueno S2, Shinchi H3, Natsugoe S1.
    • Journal Title

      Oncol Letter

      Volume: 14-2 Issue: 2 Pages: 1697-1702

    • DOI

      10.3892/ol.2017.6306

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of proton beam radiotherapy and hyper-fractionated accelerated chemoradiotherapy for locally advanced pancreatic cancer.2017

    • Author(s)
      Maemura K1, Mataki Y2, Kurahara H2, Kawasaki Y2, Iino S2, Sakoda M2, Ueno S3, Arimura T4, Higashi R5, Yoshiura T5, Shinchi H6, Natsugoe S2.
    • Journal Title

      Pancreatology.

      Volume: 17-5 Issue: 5 Pages: 833-838

    • DOI

      10.1016/j.pan.2017.07.191

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Anterior approach for right hepatectomy with hanging maneuver for hepatocellular carcinoma: a multi-institutional propensity score-matching study.2017

    • Author(s)
      Beppu T, Imai K, Okuda K, Eguchi S, Kitahara K, Taniai N, Ueno S, Shirabe K, Ohta M, Kondo K, Nanashima A, Noritomi T, Shiraishi M, Takami Y, Okamoto K, Kikuchi K, Baba H, Fujioka H.
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: 24 Issue: 3 Pages: 127-136

    • DOI

      10.1002/jhbp.431

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Evaluation of Liver Function and Surgical Influence by ICGR15 after Chemotherapy for Colorectal Liver Metastases.2016

    • Author(s)
      Hiwatashi K, Ueno S, Sakoda M, Iino S, Minami K, Mori S, Kita Y, Baba K, Kurahara H, Mataki Y, Maemura K, Shinchi H, Natsugoe S
    • Journal Title

      J Cancer

      Volume: 18 Issue: 5 Pages: 595-599

    • DOI

      10.7150/jca.13759

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Portal Vein Embolization Followed by Right-Side Hemihepatectomy for Hepatocellular Carcinoma Patients: A Japanese Multi-Institutional Study.2016

    • Author(s)
      Beppu T, Okabe H, Okuda K, Eguchi S, Kitahara K, Taniai N, Ueno S, Shirabe K, Ohta M, Kondo K, Nanashima A, Noritomi T, Okamoto K, Kikuchi K, Baba H, Fujioka H.
    • Journal Title

      J Am Coll Surg

      Volume: S1072-7515 Pages: 1-12

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Problems of Long Survival Following Surgery in Patients with NonBNonC-HCC: Comparison with HBV and HCV Related-HCC.2015

    • Author(s)
      Hiwatashi K, Ueno S, Sakoda M, Iino S, Minami K, Yamasaki Y, Okubo K, Noda M, Kurahara H, Mataki Y, Maemura K, Shinchi H, Natsugoe S.
    • Journal Title

      J Cancer

      Volume: 6 Issue: 5 Pages: 438-447

    • DOI

      10.7150/jca.10398

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 当科で経験したS-1併用過分割照射による膵癌症例の検討2017

    • Author(s)
      又木 雄弘(鹿児島大学 大学院医歯学総合研究科消化器・乳腺甲状腺外科), 前村 公成, 蔵原 弘, 川崎 洋太, 橋口 真征, 迫田 雅彦, 飯野 聡, 上野 真一, 新地 洋之, 夏越 祥次
    • Organizer
      日本癌治療学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] リンパ節転移からみた十二指腸乳頭部癌に対する治療戦略2017

    • Author(s)
      前村 公成(鹿児島大学 大学院医歯学総合研究科消化器・乳腺甲状腺外科), 又木 雄弘, 蔵原 弘, 川崎 洋太, 橋口 真征, 飯野 聡, 迫田 雅彦, 上野 真一, 新地 洋之, 夏越 祥次
    • Organizer
      日本癌治療学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 切除可能膵癌に対する新たな治療戦略(英語)2017

    • Author(s)
      蔵原 弘(鹿児島大学 大学院医歯学総合研究科腫瘍制御学消化器乳腺甲状腺外科), 前村 公成, 又木 雄弘, 迫田 雅彦, 飯野 聡, 川崎 洋太, 橋口 真征, 上野 真一, 新地 洋之, 夏越 祥次
    • Organizer
      日本癌治療学会学術集会
    • Related Report
      2017 Research-status Report

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Published: 2015-04-16   Modified: 2021-02-19  

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