Development of new immunotherapy for intractable gastrointestinal cancer

• Project/Area Number: 15K10034
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Nara Medical University
• Principal Investigator: Sho Masayuki 奈良県立医科大学, 医学部, 教授 (50364063)
• Research Collaborator: NISHIWADA Satoshi ; KINOSHITA Shoichi
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 膵癌 / 消化器癌 / 腫瘍免疫 / HVEM / 癌免疫 / Pectin / CD155 / Nectin

Outline of Final Research Achievements

In this study, we have evaluated HVEM expression in hepatocellular carcinoma and colorectal cancer. As a result, tumor HVEM expression had a significant prognostic value. Furthermore, HVEM expression was inversely correlated with tumor-infiltrating T cells, suggesting its important role in tumor immunity.
In addition, we have evaluated CD155 and Nectin family in human pancreatic cancer. We found such molecules had significant prognostic value and played an important role in pancreatic cancer. Therefore, targeting T cell negative pathways including HVEM, CD155, and Nectin family may hold significant promise for future clinical application in cancer immunotherapy.

Research Products

• [Journal Article] K-ras mutation analysis of residual liquid-based cytology specimens from endoscopic ultrasound-guided fine needle aspiration improves cell block diagnosis of pancreatic ductal adenocarcinoma (2018)
  • Author(s): Sekita-Hatakeyama Yoko、Nishikawa Takeshi、Takeuchi Mao、Morita Kouhei、Takeda Maiko、Hatakeyama Kinta、Nakai Tokiko、Uchiyama Tomoko、Itami Hiroe、Fujii Tomomi、Mitoro Akira、Sho Masayuki、Ohbayashi Chiho
  • Journal Title: PLOS ONE Volume: 13 Issue: 3 Pages: e0193692-e0193692
  • DOI: 10.1371/journal.pone.0193692
  • Peer Reviewed
• [Journal Article] von Willebrand factor aggravates hepatic ischemia-reperfusion injury by promoting neutrophil recruitment in mice (2018)
  • Author(s): Urisono Y, Sakata A, Matsui H, Kasuda S, Ono S, Nishio K, Sho M, Okuchi K, Akiyama M, Miyata T, Nishimura S, Sugimoto M
  • Journal Title: Thromb Haemost Volume: 118 Issue: 04 Pages: 700-708
  • DOI: 10.1055/s-0038-1636529
  • Peer Reviewed
• [Journal Article] Preoperative Plasma Fibrinogen is Associated with Lymph Node Metastasis and Predicts Prognosis in Resectable Esophageal Cancer (2017)
  • Author(s): Kohei Wakatsuki
  • Journal Title: World Journal of Surgery Volume: - Issue: 8 Pages: 2068-2077
  • DOI: 10.1007/s00268-017-3991-x
  • Peer Reviewed
• [Journal Article] Intraarterial Therapy Using Micellar Nanoparticles Incorporating SN-38 in a Rabbit Liver Tumor Model (2017)
  • Author(s): Hideyuki Nishiofuku
  • Journal Title: J Vasc Interv Radiol. Volume: 28 Issue: 3 Pages: 457-464
  • DOI: 10.1016/j.jvir.2016.10.032
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Pharmacokinetics and Histopathological Findings of Chemoembolization Using Cisplatin Powder Mixed with Degradable Starch Microspheres in a Rabbit Liver Tumor Model. (2017)
  • Author(s): Sato T, Tanaka T, Nishiofuku H, Fukuoka Y, Sakaguchi H, Masada T, Tatsumoto S, Marugami N, Takano M, Yamato I, Sho M, Ohbayashi C, Hirai T, Kichikawa K.
  • Journal Title: Cardiovasc Intervent Radiol Volume: 40 Issue: 3 Pages: 438-444
  • DOI: 10.1007/s00270-016-1512-1
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Nectin-4 expression contributes to tumor proliferation, angiogenesis and patient prognosis in human pancreatic cancer. (2015)
  • Author(s): Nishiwada S, Sho M, Yasuda S, Shimada K, Yamato I, Akahori T, Kinoshita S, Nagai M, Konishi N, Nakajima Y.
  • Journal Title: J Exp Clin Cancer Res. Volume: 34 Issue: 1 Pages: 30-30
  • DOI: 10.1186/s13046-015-0144-7
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Clinical significance of CD155 expression in human pancreatic cancer. (2015)
  • Author(s): Nishiwada S, Sho M, Yasuda S, Shimada K, Yamato I, Akahori T, Kinoshita S, Nagai M, Konishi N, Nakajima Y.
  • Journal Title: Anticancer Res. Volume: 35 Pages: 2287-2297
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] HVEM expression contributes to tumor progression and prognosis in human colorectal cancer. (2015)
  • Author(s): Inoue T, Sho M, Yasuda S, Nishiwada S, Nakamura S, Ueda T, Nishigori N, Kawasaki K, Obara S, Nakamoto T, Koyama F, Fujii H, Nakajima Y.
  • Journal Title: Anticancer Res. Volume: 35 Pages: 1361-1367
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 膵癌におけるNectin family腫瘍発現の臨床的意義とそのメカニズム (2016)
  • Author(s): 西和田敏，庄 雅之
  • Organizer: 第116回日本外科学会定期学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2016-04-14
• [Presentation] 肝細胞癌におけるALKBH6発現の臨床的意義と役割 (2016)
  • Author(s): 山戸一郎，庄 雅之
  • Organizer: 第116回日本外科学会定期学術集会
  • Place of Presentation: 大阪
• [Presentation] 膵癌におけるCD200発現の臨床的意義 (2016)
  • Author(s): 木下正一，庄 雅之
  • Organizer: 第116回日本外科学会定期学術集会
  • Place of Presentation: 大阪